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We evaluated smartphone application-based rehabilitation programs for patients with chronic respiratory or cardiovascular diseases. This was a single-center prospective single arm study. Participants underwent smartphone application-based pulmonary or cardiac rehabilitation for 12\u00a0weeks. A total of 93 participants were recruited, and 75 visited after rehabilitation. Their median age was 67.0 (interquartile range, 60.0\u201370.8) years, and 60 (80.0%) were men. For patients with chronic respiratory disease (n\u2009=\u200941), VO<jats:sub>2<\/jats:sub>peak (median 13.7 to 15.4\u00a0ml\/kg\/min, <jats:italic>P<\/jats:italic>\u2009=\u20090.049), chronic obstructive pulmonary disease assessment test (median 14 to 6, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), Euro-QoL 5-Dimension 5-Level (EQ-5D-5L) index (median 0.795 to 0.862, <jats:italic>P<\/jats:italic>\u2009=\u20090.001), and Health-related Quality of Life Instrument with 8 Items (HINT-8) index (median 0.784 to 0.855, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) were significantly improved. For patients with chronic cardiovascular disease (n\u2009=\u200934), VO<jats:sub>2<\/jats:sub>peak (median 21.8 to 23.3, <jats:italic>P<\/jats:italic>\u2009=\u20090.007), EQ-5D-5L index (median 0.871 to 1.000, <jats:italic>P<\/jats:italic>\u2009=\u20090.037), and HINT-8 index (median 0.890 to 0.903, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) were significantly improved. The smartphone application-based rehabilitation program improved exercise capacity and quality of life in patients with chronic respiratory or cardiovascular disease.<\/jats:p><jats:p><jats:bold>Trial registration<\/jats:bold>: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05383950\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05383950<\/jats:ext-link> (20\/05\/2022).<\/jats:p>","DOI":"10.1038\/s41598-024-53583-2","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T11:02:45Z","timestamp":1707217365000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Smartphone application-based rehabilitation in patients with chronic respiratory and cardiovascular diseases"],"prefix":"10.1038","volume":"14","clinical-trial-number":[{"clinical-trial-number":"nct05383950","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Chiwook","family":"Chung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ah-Ram","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongbum","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Ho","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Il-Young","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Woo","family":"Jo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do-Yoon","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sei Won","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,6]]},"reference":[{"key":"53583_CR1","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","volume":"396","author":"GBD 2019 Diseases and Injuries Collaborators","year":"2020","unstructured":"GBD 2019 Diseases and Injuries Collaborators. 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