{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T21:41:24Z","timestamp":1776289284272,"version":"3.50.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T00:00:00Z","timestamp":1708128000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T00:00:00Z","timestamp":1708128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated the clinical implications of the mean corpuscular volume (MCV) in patients with major trauma. This single-center retrospective review included 2021 trauma patients admitted to the intensive care unit between January 2016 and June 2020. We included 1218 patients aged <jats:inline-formula><jats:alternatives><jats:tex-math>$$\\ge $$<\/jats:tex-math><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                  <mml:mo>\u2265<\/mml:mo>\n                <\/mml:math><\/jats:alternatives><\/jats:inline-formula> 18\u00a0years with an injury severity score <jats:inline-formula><jats:alternatives><jats:tex-math>$$\\ge $$<\/jats:tex-math><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                  <mml:mo>\u2265<\/mml:mo>\n                <\/mml:math><\/jats:alternatives><\/jats:inline-formula> 16 in the final analysis. The clinical and laboratory variables were compared between macrocytosis (defined as MCV <jats:inline-formula><jats:alternatives><jats:tex-math>$$\\ge $$<\/jats:tex-math><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                  <mml:mo>\u2265<\/mml:mo>\n                <\/mml:math><\/jats:alternatives><\/jats:inline-formula> 100 fL) and non-macrocytosis groups. Cox regression analysis was performed to calculate the hazard ratios (HRs) of variables for 30-day mortality, with adjustment for other potential confounding factors. The initial mean value of MCV was 102.7 fL in the macrocytosis group (n\u2009=\u2009199) and 93.7 fL in the non-macrocytosis group (n\u2009=\u20091019). The macrocytosis group showed a significantly higher proportion of initial hypotension, transfusion within 4 and 24\u00a0h, and 30-day mortality than the non-macrocytosis group. Age (<jats:inline-formula><jats:alternatives><jats:tex-math>$$\\ge $$<\/jats:tex-math><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                  <mml:mo>\u2265<\/mml:mo>\n                <\/mml:math><\/jats:alternatives><\/jats:inline-formula> 65\u00a0years), hypotension (systolic blood pressure <jats:inline-formula><jats:alternatives><jats:tex-math>$$\\le $$<\/jats:tex-math><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                  <mml:mo>\u2264<\/mml:mo>\n                <\/mml:math><\/jats:alternatives><\/jats:inline-formula> 90\u00a0mmHg), transfusion (within 4\u00a0h), anemia (Hb\u2009&lt;\u200912\u00a0g\/day in women,\u2009&lt;\u200913\u00a0g\/day in men), and macrocytosis were significantly associated with 30-day mortality (adjusted HR\u2009=\u20091.4; 95% confidence interval 1.01\u20131.94; <jats:italic>p<\/jats:italic>\u2009=\u20090.046) in major trauma patients. Thus, <jats:bold>i<\/jats:bold>nitial macrocytosis independently predicted 30-day mortality in patients with major trauma at a Level I trauma center.<\/jats:p>","DOI":"10.1038\/s41598-024-54057-1","type":"journal-article","created":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T04:26:05Z","timestamp":1708143965000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Mean corpuscular volume as a prognostic factor for 30-day mortality in major trauma patients: a retrospective cohort study"],"prefix":"10.1038","volume":"14","author":[{"given":"Hanlim","family":"Choi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Younghoon","family":"Sul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Se Heon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Bong","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Suk","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo Young","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junepill","family":"Seok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Hee","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,17]]},"reference":[{"key":"54057_CR1","unstructured":"Alder, L. & Tambe A. 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