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Prospective study including 46 eyes of 23 patients with type 1 diabetes and 46 age-matched healthy eyes evaluated by the RETI-port\/scan21 and the portable system RETeval following ISCEV guidelines. The average duration of diabetes was 28.88\u2009\u00b1\u20098.04 years. In scotopic conditions, using the RETI-port\/scan21, diabetic patients showed an increase in b-wave implicit time (IT) (p\u2009=\u20090.017) with the lowest stimuli; a diminished b-wave amplitude (p\u2009=\u20090.005) in the mixed response, an increased IT (p\u2009=\u20090.004) with the high-intensity stimuli and an OP2 increased IT (p\u2009=\u20090.008) and decreased amplitude (p\u2009=\u20090.002). Under photopic conditions, b-wave amplitude was lower (p\u2009&lt;\u20090.001) and 30-Hz flicker response was diminished (p\u2009=\u20090.021). Using the RETeval, in scotopic conditions, diabetic patients showed a reduction in the rod b-wave amplitude (p\u2009=\u20090.009), an increase in a-wave IT with the 280 Td.s stimulus (p\u2009=\u20090.005). OP2 had an increased IT and diminished amplitude (p\u2009=\u20090.003 and p\u2009=\u20090.002 respectively). 16 Td.s flicker showed an increased IT (p\u2009=\u20090.008) and diminished amplitude (p\u2009=\u20090.048). Despite variations in values between both systems, nearly all results displayed positive correlations. Long-term type 1 diabetes patients without diabetic retinopathy exhibit alterations in scotopic conditions, as evidenced by both conventional and portable electroretinogram devices. These findings suggest a modified retinal function, particularly in rod-driven pathways, even in the absence of vascular signs.<\/jats:p>","DOI":"10.1038\/s41598-024-54099-5","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T15:04:21Z","timestamp":1707750261000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Electrophysiological findings in long-term type 1 diabetes patients without diabetic retinopathy using different ERG recording systems"],"prefix":"10.1038","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4756-8362","authenticated-orcid":false,"given":"Marta","family":"Arias-Alvarez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Tomas-Grasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6184-5718","authenticated-orcid":false,"given":"Maria","family":"Sope\u00f1a-Pinilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2710-1875","authenticated-orcid":false,"given":"Elvira","family":"Orduna-Hospital","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1234-9712","authenticated-orcid":false,"given":"Guisela","family":"Fernandez-Espinosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Bielsa-Alonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2987-6351","authenticated-orcid":false,"given":"Javier","family":"Acha-Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7988-8326","authenticated-orcid":false,"given":"Diego","family":"Rodriguez-Mena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0349-9997","authenticated-orcid":false,"given":"Isabel","family":"Pinilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,12]]},"reference":[{"key":"54099_CR1","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1080\/09286580701396720","volume":"14","author":"BE Klein","year":"2007","unstructured":"Klein, B. 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