{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T18:54:22Z","timestamp":1740164062679,"version":"3.37.3"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100019732","name":"Korean Association of Retinal Degeneration","doi-asserted-by":"publisher","award":["KARD-2016001"],"award-info":[{"award-number":["KARD-2016001"]}],"id":[{"id":"10.13039\/100019732","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Kangdong Sacred Heart Hospital Fund","award":["2018-09"],"award-info":[{"award-number":["2018-09"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to compare morphological differences of the neuroretinal rim between the temporally tilted and non-tilted optic discs in healthy eyes. We prospectively enrolled participants aged 20\u201340\u00a0years with temporally tilted or non-tilted optic discs. The optic nerve head parameters were analyzed using spectral domain-optical coherence tomography. The angle between the Bruch\u2019s membrane opening (BMO) plane and BMO-minimum rim width (BMO-MRW) was termed \u201cBMO-MRW angle\u201d. Peripapillary retinal nerve fiber layer thickness (pRNFLT) and BMO-based parameters were compared between the temporally tilted and non-tilted disc groups. As a result, 55 temporally tilted disc eyes and 38 non-tilted disc eyes were analyzed. Global pRNFLT, global BMO-MRW, and total BMO-minimum rim area (BMO-MRA) were similar between the two groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.138, 0.161, and <jats:italic>p<\/jats:italic>\u2009=\u20090.410, respectively). In the sectoral analysis, temporally tilted disc group exhibited thicker BMO-MRW in the temporal sector (<jats:italic>p<\/jats:italic>\u2009=\u20090.032) and thinner in the nasal superior and nasal sectors (<jats:italic>p<\/jats:italic>\u2009=\u20090.025 and <jats:italic>p<\/jats:italic>\u2009=\u20090.002, respectively). Temporally tilted disc group showed larger BMO-MRA in the temporal, temporal superior, and temporal inferior sectors (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, and <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.016, respectively), alongside a higher BMO-MRW angle in the temporal sector and lower in the nasal superior and nasal sectors. In conclusion, the neuroretinal rim, represented by BMO-MRW and BMO-MRA, showed morphological differences between temporally tilted and non-tilted optic discs in healthy eyes. BMO-MRW and BMO-MRA showed temporalization in the same manner as pRNFLT in the temporally tilted disc eyes. The BMO-MRW angle showed that in temporally tilted disc eyes, optic nerve fibers met the BMO plane steeply in the nasal sector and gently in the temporal sector than in non-tilted disc eyes, suggesting potential stress region of optic nerve fibers in temporally tilted disc eyes.<\/jats:p>","DOI":"10.1038\/s41598-024-54116-7","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T09:05:15Z","timestamp":1710320715000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Morphological differences of the neuroretinal rim between temporally tilted and non-tilted optic discs in healthy eyes"],"prefix":"10.1038","volume":"14","author":[{"given":"Chan Woong","family":"Joo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youn Joo","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han Ul","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Pyo","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyeong Ik","family":"Na","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,3,13]]},"reference":[{"key":"54116_CR1","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/0002-9394(83)90389-6","volume":"95","author":"HA Quigley","year":"1983","unstructured":"Quigley, H. A., Hohman, R. M., Addicks, E. M., Massof, R. W. & Green, W. R. Morphologic changes in the lamina cribrosa correlated with neural loss in open-angle glaucoma. Am. J. Ophthalmol. 95, 673\u2013691 (1983).","journal-title":"Am. J. Ophthalmol."},{"key":"54116_CR2","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1136\/bjo.2003.019281","volume":"88","author":"G Tezel","year":"2004","unstructured":"Tezel, G., Trinkaus, K. & Wax, M. B. Alterations in the morphology of lamina cribrosa pores in glaucomatous eyes. Br. J. Ophthalmol. 88, 251\u2013256 (2004).","journal-title":"Br. J. Ophthalmol."},{"key":"54116_CR3","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1097\/OPX.0000000000000516","volume":"92","author":"C-W Pan","year":"2015","unstructured":"Pan, C.-W., Dirani, M., Cheng, C.-Y., Wong, T.-Y. & Saw, S.-M. The age-specific prevalence of myopia in Asia: A meta-analysis. Optom. Vis. Sci. 92, 258\u2013266 (2015).","journal-title":"Optom. Vis. Sci."},{"key":"54116_CR4","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1016\/S0161-6420(99)90416-5","volume":"106","author":"P Mitchell","year":"1999","unstructured":"Mitchell, P., Hourihan, F., Sandbach, J. & Wang, J. J. The relationship between glaucoma and myopia: The Blue Mountains Eye study. Ophthalmology 106, 2010\u20132015 (1999).","journal-title":"Ophthalmology"},{"key":"54116_CR5","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1034\/j.1600-0420.2001.790603.x","volume":"79","author":"K Gr\u00f8dum","year":"2001","unstructured":"Gr\u00f8dum, K., Heijl, A. & Bengtsson, B. Refractive error and glaucoma. Acta. Ophthalmol. Scand. 79, 560\u2013566 (2001).","journal-title":"Acta. Ophthalmol. Scand."},{"key":"54116_CR6","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1016\/j.ophtha.2011.03.012","volume":"118","author":"MW Marcus","year":"2011","unstructured":"Marcus, M. W., de Vries, M. M., Montolio, F. G. J. & Jansonius, N. M. Myopia as a risk factor for open-angle glaucoma: A systematic review and meta-analysis. Ophthalmology 118, 1989\u20131994 (2011).","journal-title":"Ophthalmology"},{"key":"54116_CR7","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1007\/BF02169209","volume":"226","author":"JB Jonas","year":"1988","unstructured":"Jonas, J. B., Gusek, G. C. & Naumann, G. O. Optic disk morphometry in high myopia. Graefes. Arch. Clin. Exp. Ophthalmol. 226, 587\u2013590 (1988).","journal-title":"Graefes. Arch. Clin. Exp. Ophthalmol."},{"key":"54116_CR8","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1038\/eye.2008.87","volume":"22","author":"QS You","year":"2008","unstructured":"You, Q. S., Xu, L. & Jonas, J. B. Tilted optic discs: The Beijing eye study. Eye (Lond.) 22, 728\u2013729 (2008).","journal-title":"Eye (Lond.)"},{"key":"54116_CR9","doi-asserted-by":"publisher","first-page":"2050","DOI":"10.1016\/j.ophtha.2011.02.040","volume":"118","author":"C Samarawickrama","year":"2011","unstructured":"Samarawickrama, C. et al. Myopia-related optic disc and retinal changes in adolescent children from Singapore. Ophthalmology 118, 2050\u20132057 (2011).","journal-title":"Ophthalmology"},{"key":"54116_CR10","doi-asserted-by":"publisher","first-page":"100933","DOI":"10.1016\/j.preteyeres.2020.100933","volume":"83","author":"YX Wang","year":"2021","unstructured":"Wang, Y. X., Panda-Jonas, S. & Jonas, J. B. Optic nerve head anatomy in myopia and glaucoma, including parapapillary zones alpha, beta, gamma and delta: Histology and clinical features. Prog. Retin. Eye. Res. 83, 100933 (2021).","journal-title":"Prog. Retin. Eye. Res."},{"key":"54116_CR11","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/eye.2013.223","volume":"28","author":"JB Jonas","year":"2014","unstructured":"Jonas, J. B. & Xu, L. Histological changes of high axial myopia. Eye (Lond.) 28, 113\u2013117 (2014).","journal-title":"Eye (Lond.)"},{"key":"54116_CR12","doi-asserted-by":"publisher","first-page":"1844","DOI":"10.1016\/j.ophtha.2012.03.006","volume":"119","author":"HY Park","year":"2012","unstructured":"Park, H. Y., Lee, K. & Park, C. K. Optic disc torsion direction predicts the location of glaucomatous damage in normal-tension glaucoma patients with myopia. Ophthalmology 119, 1844\u20131851 (2012).","journal-title":"Ophthalmology"},{"key":"54116_CR13","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1038\/eye.2015.17","volume":"29","author":"YJ Choy","year":"2015","unstructured":"Choy, Y. J., Kwun, Y., Han, J. C. & Kee, C. Comparison of visual field progression between temporally tilted disc and nontilted disc, in patients with normal tension glaucoma. Eye (Lond.) 29, 1308\u20131314 (2015).","journal-title":"Eye (Lond.)"},{"key":"54116_CR14","doi-asserted-by":"publisher","first-page":"6925","DOI":"10.1167\/iovs.15-17892","volume":"56","author":"JE Lee","year":"2015","unstructured":"Lee, J. E., Sung, K. R., Lee, J. Y. & Park, J. M. Implications of optic disc tilt in the progression of primary open-angle glaucoma. Invest. Ophthalmol. Vis. Sci. 56, 6925\u20136931 (2015).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"54116_CR15","doi-asserted-by":"publisher","first-page":"e0170733","DOI":"10.1371\/journal.pone.0170733","volume":"12","author":"Y Sawada","year":"2017","unstructured":"Sawada, Y., Hangai, M., Ishikawa, M. & Yoshitomi, T. Association of myopic deformation of optic disc with visual field progression in paired eyes with open-angle glaucoma. PloS One 12, e0170733 (2017).","journal-title":"PloS One"},{"key":"54116_CR16","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.1167\/iovs.18-25839","volume":"60","author":"BR Seol","year":"2019","unstructured":"Seol, B. R., Park, K. H. & Jeoung, J. W. Optic disc tilt and glaucoma progression in myopic glaucoma: A longitudinal match-pair case-control study. Invest. Ophthalmol. Vis. Sci. 60, 2127\u20132133 (2019).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"54116_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-021-88406-1","volume":"11","author":"J Rezapour","year":"2021","unstructured":"Rezapour, J. et al. The influence of axial myopia on optic disc characteristics of glaucoma eyes. Sci. Rep. 11, 1\u201313 (2021).","journal-title":"Sci. Rep."},{"key":"54116_CR18","doi-asserted-by":"publisher","first-page":"2505","DOI":"10.1177\/11206721211063716","volume":"32","author":"L Zhang","year":"2022","unstructured":"Zhang, L., Liu, K., Nie, F. & Duan, X. Research advance in optic disc tilt and rotation in high myopia and its implications for glaucoma and visual field defects. Eur. J. Ophthalmol. 32, 2505\u20132514 (2022).","journal-title":"Eur. J. Ophthalmol."},{"key":"54116_CR19","doi-asserted-by":"publisher","first-page":"4075","DOI":"10.1167\/iovs.09-4737","volume":"51","author":"SH Kang","year":"2010","unstructured":"Kang, S. H., Hong, S. W., Im, S. K., Lee, S. H. & Ahn, M. D. Effect of myopia on the thickness of the retinal nerve fiber layer measured by Cirrus HD optical coherence tomography. Invest. Ophthalmol. Vis. Sci. 51, 4075\u20134083 (2010).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"54116_CR20","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1136\/bjo.2009.162206","volume":"94","author":"MJ Kim","year":"2010","unstructured":"Kim, M. J., Lee, E. J. & Kim, T.-W. Peripapillary retinal nerve fibre layer thickness profile in subjects with myopia measured using the Stratus optical coherence tomography. Br. J. Ophthalmol. 94, 115\u2013120 (2010).","journal-title":"Br. J. Ophthalmol."},{"key":"54116_CR21","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1097\/IJG.0b013e31820719e1","volume":"21","author":"YH Hwang","year":"2012","unstructured":"Hwang, Y. H., Yoo, C. & Kim, Y. Y. Myopic optic disc tilt and the characteristics of peripapillary retinal nerve fiber layer thickness measured by spectral-domain optical coherence tomography. J. Glaucoma 21, 260\u2013265 (2012).","journal-title":"J. Glaucoma"},{"key":"54116_CR22","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1016\/j.ophtha.2018.01.026","volume":"125","author":"M Kim","year":"2018","unstructured":"Kim, M., Choung, H.-K., Lee, K. M., Oh, S. & Kim, S. H. Longitudinal changes of optic nerve head and peripapillary structure during childhood myopia progression on OCT: Boramae Myopia Cohort Study Report 1. Ophthalmology 125, 1215\u20131223 (2018).","journal-title":"Ophthalmology"},{"key":"54116_CR23","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1016\/j.ophtha.2018.02.002","volume":"125","author":"KM Lee","year":"2018","unstructured":"Lee, K. M., Choung, H.-K., Kim, M., Oh, S. & Kim, S. H. Positional change of optic nerve head vasculature during axial elongation as evidence of lamina cribrosa shifting: Boramae Myopia Cohort Study Report 2. Ophthalmology 125, 1224\u20131233 (2018).","journal-title":"Ophthalmology"},{"key":"54116_CR24","doi-asserted-by":"publisher","first-page":"22435","DOI":"10.1038\/s41598-021-01184-8","volume":"11","author":"KM Lee","year":"2021","unstructured":"Lee, K. M., Ahn, H. J., Kim, M., Oh, S. & Kim, S. H. Offset of openings in optic nerve head canal at level of Bruch\u2019s membrane, anterior sclera, and lamina cribrosa. Sci. Rep. 11, 22435 (2021).","journal-title":"Sci. Rep."},{"key":"54116_CR25","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1136\/bjophthalmol-2021-320596","volume":"107","author":"M Kim","year":"2023","unstructured":"Kim, M., Lee, K. M., Choung, H.-K., Oh, S. & Kim, S. H. Change of peripapillary retinal nerve fiber layer and choroidal thickness during 4-year myopic progress: Boramae Myopia Cohort Study Report 4. Br. J. Ophthalmol. 107, 1165\u20131171 (2023).","journal-title":"Br. J. Ophthalmol."},{"key":"54116_CR26","doi-asserted-by":"publisher","first-page":"19564","DOI":"10.1038\/s41598-019-55926-w","volume":"9","author":"MS Sung","year":"2019","unstructured":"Sung, M. S., Heo, M. Y., Heo, H. & Park, S. W. Bruch\u2019s membrane opening enlargement and its implication on the myopic optic nerve head. Sci. Rep. 9, 19564 (2019).","journal-title":"Sci. Rep."},{"key":"54116_CR27","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.1167\/iovs.11-9309","volume":"53","author":"ASC Reis","year":"2012","unstructured":"Reis, A. S. C. et al. Influence of clinically invisible, but optical coherence tomography detected, optic disc margin anatomy on neuroretinal rim evaluation. Invest. Ophthalmol. Vis. Sci. 53, 1852\u20131860 (2012).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"54116_CR28","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.ajo.2013.11.007","volume":"157","author":"SK Gardiner","year":"2014","unstructured":"Gardiner, S. K. et al. A method to estimate the amount of neuroretinal rim tissue in glaucoma: Comparison with current methods for measuring rim area. Am. J. Ophthalmol. 157, 540-549.e2 (2014).","journal-title":"Am. J. Ophthalmol."},{"key":"54116_CR29","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1097\/ICU.0000000000000548","volume":"30","author":"NYQ Tan","year":"2019","unstructured":"Tan, N. Y. Q., Sng, C. C. A. & Ang, M. Myopic optic disc changes and its role in glaucoma. Curr. Opin. Ophthalmol. 30, 89\u201396 (2019).","journal-title":"Curr. Opin. Ophthalmol."},{"key":"54116_CR30","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.ogla.2019.02.008","volume":"2","author":"Y Sawada","year":"2019","unstructured":"Sawada, Y. et al. Differences in retinal nerve fiber layer thickness as assessed on the disc center and Bruch\u2019s membrane opening center in myopic eyes. Ophthalmol. Glaucoma 2, 145\u2013155 (2019).","journal-title":"Ophthalmol. Glaucoma"},{"key":"54116_CR31","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.ophtha.2012.09.055","volume":"120","author":"BC Chauhan","year":"2013","unstructured":"Chauhan, B. C. et al. Enhanced detection of open-angle glaucoma with an anatomically accurate optical coherence tomography\u2013derived neuroretinal rim parameter. Ophthalmology 120, 535\u2013543 (2013).","journal-title":"Ophthalmology"},{"key":"54116_CR32","doi-asserted-by":"publisher","first-page":"OCT575","DOI":"10.1167\/iovs.15-18906","volume":"57","author":"JMD Gmeiner","year":"2016","unstructured":"Gmeiner, J. M. D. et al. Comparison of Bruch\u2019s membrane opening minimum rim width and peripapillary retinal nerve fiber layer thickness in early glaucoma assessment. Invest. Ophthalmol. Vis. Sci. 57, OCT575\u2013OCT584 (2016).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"54116_CR33","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1097\/IJG.0000000000000675","volume":"26","author":"S Imamoglu","year":"2017","unstructured":"Imamoglu, S. et al. Structure-function relationship between the Bruch membrane opening-based minimum rim width and visual field defects in advanced glaucoma. J. Glaucoma 26, 561\u2013565 (2017).","journal-title":"J. Glaucoma"},{"key":"54116_CR34","doi-asserted-by":"publisher","first-page":"6596","DOI":"10.1167\/iovs.16-20561","volume":"57","author":"P Enders","year":"2016","unstructured":"Enders, P. et al. Novel Bruch\u2019s membrane opening minimum rim area equalizes disc size dependency and offers high diagnostic power for glaucoma. Invest. Ophthalmol. Vis. Sci. 57, 6596\u20136603 (2016).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"54116_CR35","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1111\/aos.13698","volume":"97","author":"P Enders","year":"2019","unstructured":"Enders, P. et al. Evaluation of two-dimensional Bruch\u2019s membrane opening minimum rim area for glaucoma diagnostics in a large patient cohort. Acta. Ophthalmol. 97, 60\u201367 (2019).","journal-title":"Acta. Ophthalmol."},{"key":"54116_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12886-021-01906-6","volume":"21","author":"R Li","year":"2021","unstructured":"Li, R. et al. Diagnostic capability of different morphological parameters for primary open-angle glaucoma in the Chinese population. BMC Ophthalmol. 21, 1\u20139 (2021).","journal-title":"BMC Ophthalmol."},{"key":"54116_CR37","doi-asserted-by":"publisher","first-page":"2591","DOI":"10.1167\/iovs.19-27331","volume":"60","author":"Q Zhang","year":"2019","unstructured":"Zhang, Q., Xu, L., Wei, W. B., Wang, Y. X. & Jonas, J. B. Size and shape of Bruch\u2019s membrane opening in relationship to axial length, gamma zone, and macular Bruch\u2019s membrane defects. Invest. Ophthalmol. Vis. Sci. 60, 2591\u20132598 (2019).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"54116_CR38","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1097\/IJG.0000000000001947","volume":"30","author":"HS Choi","year":"2021","unstructured":"Choi, H. S., Joo, C. W., Park, S. P. & Na, K. I. A decrease in Bruch\u2019s membrane opening-minimum rim area precedes decreased retinal nerve fiber layer thickness and visual field loss in glaucoma. J. Glaucoma 30, 1033\u20131038 (2021).","journal-title":"J. Glaucoma"},{"key":"54116_CR39","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.ajo.2011.01.052","volume":"152","author":"K Ohno-Matsui","year":"2011","unstructured":"Ohno-Matsui, K. et al. Long-term development of significant visual field defects in highly myopic eyes. Am. J. Ophthalmol. 152, 256-265.e1 (2011).","journal-title":"Am. J. Ophthalmol."},{"key":"54116_CR40","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1136\/bjophthalmol-2015-307942","volume":"100","author":"X Ding","year":"2016","unstructured":"Ding, X. et al. Visual field defect classification in the Zhongshan ophthalmic center\u2013Brien Holden vision institute high Myopia Registry Study. Br. J. Ophthalmol. 100, 1697\u20131702 (2016).","journal-title":"Br. J. Ophthalmol."},{"key":"54116_CR41","doi-asserted-by":"publisher","first-page":"9385","DOI":"10.1038\/s41598-021-88832-1","volume":"11","author":"J Lee","year":"2021","unstructured":"Lee, J., Park, C. K. & Jung, K. I. Characteristics of progressive temporal visual field defects in patients with myopia. Sci. Rep. 11, 9385 (2021).","journal-title":"Sci. Rep."},{"key":"54116_CR42","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.ajo.2021.05.011","volume":"229","author":"Y Sawada","year":"2021","unstructured":"Sawada, Y., Araie, M. & Shibata, H. Vertical position of the central retinal vessel in the optic disc and its association with the site of visual field defects in glaucoma. Am. J. Ophthalmol. 229, 253\u2013265 (2021).","journal-title":"Am. J. Ophthalmol."},{"key":"54116_CR43","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.ogla.2018.05.003","volume":"1","author":"KM Lee","year":"2018","unstructured":"Lee, K. M., Kim, M., Oh, S. & Kim, S. H. Position of central retinal vascular trunk and preferential location of glaucomatous damage in myopic normal-tension glaucoma. Ophthalmol. Glaucoma 1, 32\u201343 (2018).","journal-title":"Ophthalmol. Glaucoma"},{"key":"54116_CR44","doi-asserted-by":"publisher","first-page":"e0233270","DOI":"10.1371\/journal.pone.0233270","volume":"15","author":"KM Lee","year":"2020","unstructured":"Lee, K. M., Kim, M., Oh, S. & Kim, S. H. Hemisphere opposite to vascular trunk deviation is earlier affected by glaucomatous damage in myopic high-tension glaucoma. PLoS One 15, e0233270 (2020).","journal-title":"PLoS One"},{"key":"54116_CR45","doi-asserted-by":"publisher","first-page":"4927","DOI":"10.1167\/iovs.14-15819","volume":"56","author":"H-YL Park","year":"2015","unstructured":"Park, H.-Y.L., Choi, S. I., Choi, J.-A. & Park, C. K. Disc torsion and vertical disc tilt are related to subfoveal scleral thickness in open-angle glaucoma patients with myopia. Invest. Ophthalmol. Vis. Sci. 56, 4927\u20134935 (2015).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"54116_CR46","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.ophtha.2015.10.018","volume":"123","author":"MS Sung","year":"2016","unstructured":"Sung, M. S., Kang, Y. S., Heo, H. & Park, S. W. Characteristics of optic disc rotation in myopic eyes. Ophthalmology 123, 400\u2013407 (2016).","journal-title":"Ophthalmology"},{"key":"54116_CR47","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.ajo.2004.08.076","volume":"139","author":"E Tay","year":"2005","unstructured":"Tay, E. et al. Optic disk ovality as an index of tilt and its relationship to myopia and perimetry. Am. J. Ophthalmol. 139, 247\u2013252 (2005).","journal-title":"Am. J. Ophthalmol."},{"key":"54116_CR48","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1016\/S0161-6420(00)00284-0","volume":"107","author":"DF Garway-Heath","year":"2000","unstructured":"Garway-Heath, D. F., Poinoosawmy, D., Fitzke, F. W. & Hitchings, R. A. Mapping the visual field to the optic disc in normal tension glaucoma eyes. Ophthalmology 107, 1809\u20131815 (2000).","journal-title":"Ophthalmology"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-54116-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-54116-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-54116-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T09:07:14Z","timestamp":1710320834000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-54116-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,13]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["54116"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-54116-7","relation":{},"ISSN":["2045-2322"],"issn-type":[{"type":"electronic","value":"2045-2322"}],"subject":[],"published":{"date-parts":[[2024,3,13]]},"assertion":[{"value":"23 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"6070"}}