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MC-NPs were synthesized through ion cross-linking, were characterized using transmission electron microscopy (TEM) and laser particle size scattering. The influence of MC-NPs on the proliferation capacity of KFBs was assessed using the MTT method. Changes in the expression levels of miR-214 and A2AR in KFBs, normal skin fibroblasts (NFBs), hypertrophic scar tissue, and normal skin tissue were analyzed. KFBs were categorized into anti-miR-214, anti-miR-NC, miR-214 mimics, miR-NC, si-A2AR, si-con, anti-miR-214+\u2009si-con, and anti-miR-214+\u2009si-A2AR groups. Bioinformatics target prediction was conducted to explore the interaction between miR-214 and A2AR. Real-time quantitative PCR and immunoblotting (WB) were employed to detect the expression levels of miR-214, A2AR, apoptotic protein Bax, and TGF-\u03b2 in different cells. Cell counting kit-8 (CCK8) and flow cytometry were employed to assess cell proliferation activity and apoptosis. The results indicated that MC-NPs exhibited spherical particles with an average diameter of 236.47\u2009\u00b1\u20094.98\u00a0nm. The cell OD value in the MC-NPs group was lower than that in KFBs (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The mRNA levels of miR-214 in KFBs and hypertrophic scar tissue were lower than those in NFBs and normal tissue (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), while the mRNA and protein levels of A2AR were significantly elevated (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Compared to the control group and anti-miR-NC, the anti-miR-214 group showed significantly increased cell OD values and Bcl-2 protein expression (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), decreased levels of apoptotic gene Bax protein, TGF-\u03b2 gene mRNA, and protein expression (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Continuous complementary binding sites were identified between miR-214 and A2AR. Compared to the control group, the si-A2AR group exhibited a significant decrease in A2AR gene mRNA and protein expression levels (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), reduced cell viability (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), increased apoptosis rate (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and a significant elevation in TGF-\u03b2 protein expression (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). miR-214 targetedly regulated the expression of A2AR, inducing changes in TGF-\u03b2 content, promoting the proliferation of keloid fibroblasts, and inhibiting cell apoptosis.<\/jats:p>","DOI":"10.1038\/s41598-024-54125-6","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T14:02:12Z","timestamp":1709128932000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of miR-214 on adenosine A2A receptor and carboxymethyl chitosan nanoparticles on the function of keloid fibroblasts and their mechanisms"],"prefix":"10.1038","volume":"14","author":[{"given":"Yong","family":"Du","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aijun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongzhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ninghan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,28]]},"reference":[{"issue":"1","key":"54125_CR1","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1272\/jnms.JNMS.2021_88-106","volume":"88","author":"R Ogawa","year":"2021","unstructured":"Ogawa, R., Dohi, T., Tosa, M., Aoki, M. & Akaishi, S. 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