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This study evaluated the comparative antioxidant activity and phytochemical contents of five extracts of\n                    <jats:italic>P. ostreatus<\/jats:italic>\n                    : aqueous (AE), chloroform (CE), ethanol (EE), methanol (ME) and n-hexane (HE). The phytochemical composition and antioxidant activity of the extracts were determined using standard in-vitro antioxidant assay methods. Results showed that the extracts contained alkaloids, tannins, saponins, flavonoids, terpenoids, phenolics, cardiac glycosides, carbohydrates, anthrocyanins, and betacyanins in varied amounts. CE had the highest flavonoid content (104.83\u2009\u00b1\u200929.46\u00a0mg\/100\u00a0g); AE gave the highest phenol content of 24.14\u2009\u00b1\u20090.02\u00a0mg\/100\u00a0g; tannin was highest in EE (25.12\u2009\u00b1\u20090.06\u00a0mg\/100\u00a0g); HE had highest amounts of alkaloids (187.60\u2009\u00b1\u20090.28\u00a0mg\/100\u00a0g) and saponins (0.16\u2009\u00b1\u20090.00\u00a0mg\/100\u00a0g). Antioxidant analyses revealed that CE had the best hydroxyl radical activity of 250% at 100\u00a0\u00b5g\/ml and ferric cyanide reducing power of 8495\u00a0\u00b5g\/ml; ME gave the maximum DPPH activity (87.67%) and hydrogen peroxide scavenging activity (65.58%) at 500\u00a0\u00b5g\/ml; EE had the highest nitric oxide radical inhibition of 65.81% at 500\u00a0\u00b5g\/ml and ascorbate peroxidase activity of 1.60 (iU\/l). AE had the best total antioxidant capacity (5.27\u00a0\u00b5g\/ml GAE at 500\u00a0\u00b5g\/ml) and ferrous iron chelating activity (99.23% at 100\u00a0\u00b5g\/ml) while HE gave the highest guaiacol peroxidase activity of 0.20(iU\/l). The comparative phytochemical and antioxidant characteristics (IC\n                    <jats:sub>50<\/jats:sub>\n                    ) of the extracts followed the order: CE\u2009&gt;\u2009AE\u2009&gt;\u2009EE\u2009&gt;\u2009ME\u2009&gt;\u2009HE. Overall, chloroform was the best extraction solvent for\n                    <jats:italic>P. ostreatus<\/jats:italic>\n                    . The high content of phenolic compounds, flavonoids, and alkaloids in\n                    <jats:italic>P. ostreatus<\/jats:italic>\n                    makes it a rich source of antioxidants and potential candidate for the development of new therapies for a variety of oxidative stress-related disorders.\n                  <\/jats:p>","DOI":"10.1038\/s41598-024-54201-x","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T06:02:53Z","timestamp":1707976973000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["Comparative antioxidant activity and phytochemical content of five extracts of Pleurotus ostreatus (oyster mushroom)"],"prefix":"10.1038","volume":"14","author":[{"given":"Magdalene Eno","family":"Effiong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chidinma Precious","family":"Umeokwochi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israel Sunmola","family":"Afolabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalom Nwodo","family":"Chinedu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,15]]},"reference":[{"issue":"1","key":"54201_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1088\/1755-1315\/210\/1\/012010","volume":"210","author":"DO Enoma","year":"2018","unstructured":"Enoma, D. 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