{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:00:15Z","timestamp":1790060415450,"version":"4.0.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:00:00Z","timestamp":1707955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:00:00Z","timestamp":1707955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["112-2314-B-002-010"],"award-info":[{"award-number":["112-2314-B-002-010"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["112-2923-B-002-001-MY3"],"award-info":[{"award-number":["112-2923-B-002-001-MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["113-N0075 and 113-X0018"],"award-info":[{"award-number":["113-N0075 and 113-X0018"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Lobar cerebral microbleeds are a characteristic neuroimaging finding in cerebral amyloid angiopathy (CAA) but can also be found in hypertensive arteriolosclerosis. We aimed to investigate whether CAA is more associated with intracortical lobar microbleeds than hypertensive arteriosclerosis. Ninety-one survivors of spontaneous intracerebral hemorrhage with at least one lobar microbleed were included and underwent brain MRI and amyloid PET. We categorized lobar microbleeds as intracortical, juxtacortical, or subcortical. We assessed the associations between the lobar microbleed categories and microangiopathy subtypes or cerebral amyloid load based on the Pittsburgh Compound-B PET standardized uptake value ratio (SUVR). Patients with CAA had a higher prevalence of intracortical\u00a0lobar microbleeds (80.0% vs. 50.8%,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.011) and lower prevalence of subcortical lobar microbleeds (13.3% vs. 60.1%,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001) than patients with hypertensive arteriolosclerosis. Strictly intracortical\/juxtacortical lobar microbleeds were associated with CAA (OR\u200918.9 [1.9\u2013191.4],\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.013), while the presence of subcortical lobar microbleeds was associated with hypertensive arteriolosclerosis (OR\u200910.9 [1.8\u201368.1],\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.010). Amyloid retention was higher in patients with strictly intracortical\/juxtacortical CMBs than those without (SUVR\u2009=\u20091.15 [1.05\u20131.52] vs. 1.08 [1.02\u20131.19],\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.039). Amyloid retention positively correlated with the number of intracortical lobar microbleeds (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001) and negatively correlated with the number of subcortical lobar microbleeds (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.018). CAA and cortical amyloid deposition are more strongly associated with strictly intracortical\/juxtacortical microbleeds than subcortical lobar microbleeds. Categorization of lobar microbleeds based on anatomical location may help differentiate the underlying microangiopathy and potentially improve the accuracy of current neuroimaging criteria for cerebral small vessel disease.\n                  <\/jats:p>","DOI":"10.1038\/s41598-024-54243-1","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T21:02:09Z","timestamp":1707944529000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Differences in lobar microbleed topography in cerebral amyloid angiopathy and hypertensive arteriopathy"],"prefix":"10.1038","volume":"14","author":[{"given":"Pin-Yan","family":"Kuo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Hsi","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-Ching","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pu-Tien","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Ju","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Fang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiann-Shing","family":"Jeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoh-Fang","family":"Yen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Kai","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,15]]},"reference":[{"key":"54243_CR1","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/S1474-4422(10)70104-6","volume":"9","author":"L Pantoni","year":"2010","unstructured":"Pantoni, L. Cerebral small vessel disease: From pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol. 9, 689\u2013701 (2010).","journal-title":"Lancet Neurol."},{"key":"54243_CR2","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1056\/NEJM200105103441907","volume":"344","author":"AI Qureshi","year":"2001","unstructured":"Qureshi, A. I. et al. Spontaneous intracerebral hemorrhage. N. Engl. J. Med. 344, 1450\u20131460 (2001).","journal-title":"N. Engl. J. Med."},{"key":"54243_CR3","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1212\/WNL.56.4.537","volume":"56","author":"KA Knudsen","year":"2001","unstructured":"Knudsen, K. A., Rosand, J., Karluk, D. & Greenberg, S. M. Clinical diagnosis of cerebral amyloid angiopathy: Validation of the Boston Criteria. 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