{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:36:09Z","timestamp":1790030169656,"version":"4.0.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:00:00Z","timestamp":1708473600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:00:00Z","timestamp":1708473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Brazilian Organization for Crohn's Disease and Colitis - GEDIIB"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Brazilian Organization for Crohn's Disease and Colitis (GEDIIB) established a national registry of inflammatory bowel disease (IBD). The aim of the study was to identify clinical factors associated with disease severity in IBD patients in Brazil. A population-based risk model aimed at stratifying the severity of IBD based on previous hospitalization, use of biologics, and need for surgery for ulcerative colitis (UC) and Crohn\u2019s Disease (CD) and on previous complications for CD. A total of 1179 patients (34.4\u2009\u00b1\u200914.7y; females 59%) were included: 46.6% with UC, 44.2% with CD, and 0.9% with unclassified IBD (IBD-U). The time from the beginning of the symptoms to diagnosis was 3.85y. In CD, 41.2% of patients presented with ileocolic disease, 32% inflammatory behavior, and 15.5% perianal disease. In UC, 46.3% presented with extensive colitis. Regarding treatment, 68.1%, 67%, and 47.6% received biological therapy, salicylates and immunosuppressors, respectively. Severe disease was associated with the presence of extensive colitis, EIM, male, comorbidities, and familial history of colorectal cancer in patients with UC. The presence of Montreal B2 and B3 behaviors, colonic location, and EIM were associated with CD severity. In conclusion, disease severity was associated with younger age, greater disease extent, and the presence of rheumatic EIM.<\/jats:p>","DOI":"10.1038\/s41598-024-54332-1","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T15:03:09Z","timestamp":1708527789000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinical factors associated with severity in patients with inflammatory bowel disease in Brazil based on 2-year national registry data from GEDIIB"],"prefix":"10.1038","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3256-4698","authenticated-orcid":false,"given":"Renata de S\u00e1 Brito","family":"Fr\u00f3es","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6012-2155","authenticated-orcid":false,"given":"Adriana Ribas","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4121-0306","authenticated-orcid":false,"given":"Mikaell Alexandre Gouvea","family":"Faria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3647-7324","authenticated-orcid":false,"given":"Heitor Siffert Pereira","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5566-9284","authenticated-orcid":false,"given":"Rog\u00e9rio Serafim","family":"Parra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5236-6501","authenticated-orcid":false,"given":"Cyrla","family":"Zaltman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1181-7329","authenticated-orcid":false,"given":"Carlos Henrique Marques","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5585-3957","authenticated-orcid":false,"given":"Mauro","family":"Bafutto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3985-7402","authenticated-orcid":false,"given":"Abel Botelho","family":"Quaresma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5936-9791","authenticated-orcid":false,"given":"Genoile Oliveira","family":"Santana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2757-8104","authenticated-orcid":false,"given":"Rafael Lu\u00eds","family":"Luporini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1250-2628","authenticated-orcid":false,"given":"S\u00e9rgio Figueiredo","family":"de Lima Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4487-5004","authenticated-orcid":false,"given":"Sender Jankiel","family":"Miszputen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0520-7425","authenticated-orcid":false,"given":"Mardem Machado","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8159-4618","authenticated-orcid":false,"given":"Giedre Soares Prates","family":"Herrerias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1952-1255","authenticated-orcid":false,"given":"Roberto Luiz Kaiser","family":"Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3053-1662","authenticated-orcid":false,"given":"Catiane Rios","family":"do Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3593-0526","authenticated-orcid":false,"given":"Omar","family":"F\u00e9res","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1451-8794","authenticated-orcid":false,"given":"Jaqueline Ribeiro","family":"de Barros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7319-8906","authenticated-orcid":false,"given":"Ligia Yukie","family":"Sassaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8166-0304","authenticated-orcid":false,"given":"Rogerio","family":"Saad-Hossne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,21]]},"reference":[{"issue":"2","key":"54332_CR1","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1053\/j.gastro.2016.10.020","volume":"152","author":"GG Kaplan","year":"2017","unstructured":"Kaplan, G. G. & Ng, S. C. Understanding and Preventing the global increase of inflammatory bowel disease. Gastroenterology 152(2), 313-321.e. https:\/\/doi.org\/10.1053\/j.gastro.2016.10.020 (2017).","journal-title":"Gastroenterology"},{"issue":"11","key":"54332_CR2","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1093\/ibd\/izab346","volume":"28","author":"MA da Luz","year":"2022","unstructured":"da Luz, M. A. et al. Geosocial features and loss of biodiversity underlie variable rates of inflammatory bowel disease in a large developing country: A population-based study. Inflamm. Bowel Dis. 28(11), 1696\u20131708. https:\/\/doi.org\/10.1093\/ibd\/izab346 (2022).","journal-title":"Inflamm. Bowel Dis."},{"issue":"13","key":"54332_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.lana.2022.100298","volume":"9","author":"AB Quaresma","year":"2022","unstructured":"Quaresma, A. B. et al. Temporal trends in the epidemiology of inflammatory bowel diseases in the public healthcare system in Brazil: A large population-based study. Lancet Reg. Health Am. 9(13), 100298. https:\/\/doi.org\/10.1016\/j.lana.2022.100298 (2022).","journal-title":"Lancet Reg. Health Am."},{"issue":"1","key":"54332_CR4","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/s41575-020-00360-x","volume":"18","author":"GG Kaplan","year":"2021","unstructured":"Kaplan, G. G. & Windsor, J. W. The four epidemiological stages in the global evolution of inflammatory bowel disease. Nat. Rev. Gastroenterol. Hepatol. 18(1), 56\u201366. https:\/\/doi.org\/10.1038\/s41575-020-00360-x (2021).","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"4","key":"54332_CR5","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1097\/MOG.0000000000000534","volume":"35","author":"AB Quaresma","year":"2019","unstructured":"Quaresma, A. B., Kaplan, G. G. & Kotze, P. G. The globalization of inflammatory bowel disease: The incidence and prevalence of inflammatory bowel disease in Brazil. Curr. Opin. Gastroenterol. 35(4), 259\u2013264. https:\/\/doi.org\/10.1097\/MOG.0000000000000534 (2019).","journal-title":"Curr. Opin. Gastroenterol."},{"issue":"9","key":"54332_CR6","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1093\/ecco-jcc\/jjab048","volume":"15","author":"J Torres","year":"2021","unstructured":"Torres, J. et al. Results of the Seventh Scientific Workshop of ECCO: Precision medicine in IBD-prediction and prevention of inflammatory bowel disease. J. Crohns Colitis 15(9), 1443\u20131454. https:\/\/doi.org\/10.1093\/ecco-jcc\/jjab048 (2021).","journal-title":"J. Crohns Colitis"},{"issue":"25","key":"54332_CR7","doi-asserted-by":"publisher","first-page":"3611","DOI":"10.3748\/wjg.v26.i25.3611","volume":"26","author":"VCL Salgado","year":"2020","unstructured":"Salgado, V. C. L. et al. Risk factors associated with inflammatory bowel disease: A multicenter case-control study in Brazil. World J. Gastroenterol. 26(25), 3611\u20133624. https:\/\/doi.org\/10.3748\/wjg.v26.i25.3611 (2020).","journal-title":"World J. Gastroenterol."},{"issue":"7","key":"54332_CR8","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1136\/gutjnl-2016-311785","volume":"65","author":"J Torres","year":"2016","unstructured":"Torres, J., Burisch, J., Riddle, M., Dubinsky, M. & Colombel, J. F. Preclinical disease and preventive strategies in IBD: Perspectives, challenges and opportunities. Gut 65(7), 1061\u20131069. https:\/\/doi.org\/10.1136\/gutjnl-2016-311785 (2016).","journal-title":"Gut"},{"issue":"2","key":"54332_CR9","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1111\/jgh.12803","volume":"30","author":"C Herrera-deGuise","year":"2015","unstructured":"Herrera-deGuise, C., Casellas, F., Robles, V., Navarro, E. & Borruel, N. Predictive value of early restoration of quality of life in Crohn\u2019s disease patients receiving antitumor necrosis factor agents. J. Gastroenterol. Hepatol. 30(2), 286\u2013291. https:\/\/doi.org\/10.1111\/jgh.12803 (2015).","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"3","key":"54332_CR10","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.cgh.2015.06.001","volume":"14","author":"L Peyrin-Biroulet","year":"2016","unstructured":"Peyrin-Biroulet, L. et al. Defining disease severity in inflammatory bowel diseases: Current and future directions. Clin. Gastroenterol. Hepatol. 14(3), 348-354.e17. https:\/\/doi.org\/10.1016\/j.cgh.2015.06.001 (2016).","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"2","key":"54332_CR11","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1093\/ecco-jcc\/jjw169","volume":"11","author":"P Gionchetti","year":"2017","unstructured":"Gionchetti, P. et al. 3rd European evidence-based consensus on the diagnosis and management of Crohn\u2019s disease 2016: Part 2: Surgical management and special situations. J. Crohns Colitis 11(2), 135\u2013149. https:\/\/doi.org\/10.1093\/ecco-jcc\/jjw169 (2017).","journal-title":"J. Crohns Colitis"},{"issue":"1","key":"54332_CR12","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1093\/ecco-jcc\/jjw168","volume":"11","author":"F Gomoll\u00f3n","year":"2017","unstructured":"Gomoll\u00f3n, F. et al. 3rd European evidence-based consensus on the diagnosis and management of Crohn\u2019s disease 2016: Part 1: Diagnosis and medical management. J. Crohns Colitis 11(1), 3\u201325. https:\/\/doi.org\/10.1093\/ecco-jcc\/jjw168 (2017).","journal-title":"J. Crohns Colitis"},{"issue":"6","key":"54332_CR13","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1093\/ecco-jcc\/jjx008","volume":"11","author":"F Magro","year":"2017","unstructured":"Magro, F. et al. Third European evidence-based consensus on diagnosis and management of ulcerative colitis. Part 1: definitions, diagnosis, extra-intestinal manifestations, pregnancy, cancer surveillance, surgery, and ileo-anal pouch disorders. J. Crohns Colitis 11(6), 649\u2013670. https:\/\/doi.org\/10.1093\/ecco-jcc\/jjx008 (2017).","journal-title":"J. Crohns Colitis"},{"issue":"6","key":"54332_CR14","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1136\/gut.2005.082909","volume":"55","author":"J Satsangi","year":"2006","unstructured":"Satsangi, J., Silverberg, M. S., Vermeire, S. & Colombel, J. F. The Montreal classification of inflammatory bowel disease: Controversies, consensus, and implications. Gut 55(6), 749\u2013753. https:\/\/doi.org\/10.1136\/gut.2005.082909 (2006).","journal-title":"Gut"},{"issue":"6","key":"54332_CR15","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1590\/S0034-8910200800060000,","volume":"42","author":"LMS Coutinho","year":"2008","unstructured":"Coutinho, L. M. S., Scazufca, M. & Menezes, P. R. M\u00e9todos para estimar raz\u00e3o de preval\u00eancia em estudos de corte transversal. Rev. Sa\u00fade P\u00fabl. 42(6), 992\u2013998. https:\/\/doi.org\/10.1590\/S0034-8910200800060000, (2008).","journal-title":"Rev. Sa\u00fade P\u00fabl."},{"key":"54332_CR16","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/BF02294361","volume":"52","author":"H Bozdogan","year":"1987","unstructured":"Bozdogan, H. Model selection and Akaike\u2019s information criterion (AIC): The general theory and its analytical extensions. Psychometrika 52, 345\u2013370. https:\/\/doi.org\/10.1007\/BF02294361 (1987).","journal-title":"Psychometrika"},{"key":"54332_CR17","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9781139013567","volume-title":"Regression Analysis of Count Data","author":"AC Cameron","year":"2013","unstructured":"Cameron, A. C. & Trivedi, P. K. Regression Analysis of Count Data 2nd edn. (Cambridge University Press, 2013).","edition":"2"},{"issue":"2","key":"54332_CR18","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1080\/00031305.2016.1154108","volume":"70","author":"RL Wasserstein","year":"2016","unstructured":"Wasserstein, R. L. & Lazar, N. A. The ASA statement on p-values: Context, process, and purpose. Am. Stat. 70(2), 129\u2013133. https:\/\/doi.org\/10.1080\/00031305.2016.1154108 (2016).","journal-title":"Am. Stat."},{"issue":"7","key":"54332_CR19","first-page":"675","volume":"76","author":"DA Ludwig","year":"2005","unstructured":"Ludwig, D. A. Use and misuse of p-values in designed and observational studies: Guide for researchers and reviewers. Aviat. Space Environ. Med. 76(7), 675\u2013680 (2005).","journal-title":"Aviat. Space Environ. Med."},{"key":"54332_CR20","doi-asserted-by":"publisher","unstructured":"Dodge Y. The Concise Encyclopedia of Statistics. 2010 a edi\u00e7\u00e3o (Springer, Philadelphia, 2008). Google Search [Internet]. [cited 2023 Apr 18]. https:\/\/doi.org\/10.1007\/978-0-387-32833-1","DOI":"10.1007\/978-0-387-32833-1"},{"key":"54332_CR21","unstructured":"R: The R Project for Statistical Computing [Internet]. [cited 2023 Apr 18]. Available from: https:\/\/www.r-project.org\/"},{"issue":"2","key":"54332_CR22","doi-asserted-by":"publisher","first-page":"99","DOI":"10.3349\/ymj.2021.62.2.99","volume":"62","author":"J Park","year":"2021","unstructured":"Park, J. & Cheon, J. H. Incidence and prevalence of inflammatory bowel disease across Asia. Yonsei Med. J. 62(2), 99\u2013108. https:\/\/doi.org\/10.3349\/ymj.2021.62.2.99 (2021).","journal-title":"Yonsei Med. J."},{"issue":"2","key":"54332_CR23","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.cgh.2019.06.030","volume":"18","author":"PG Kotze","year":"2020","unstructured":"Kotze, P. G. et al. Progression of inflammatory bowel diseases throughout Latin America and the Caribbean: A systematic review. Clin. Gastroenterol. Hepatol. 18(2), 304\u2013312. https:\/\/doi.org\/10.1016\/j.cgh.2019.06.030 (2020).","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"10","key":"54332_CR24","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1016\/S2468-1253(22)00047-4","volume":"7","author":"G Watermeyer","year":"2022","unstructured":"Watermeyer, G. et al. Inflammatory bowel disease in sub-Saharan Africa: Epidemiology, risk factors, and challenges in diagnosis. Lancet Gastroenterol. Hepatol. 7(10), 952\u2013961. https:\/\/doi.org\/10.1016\/S2468-1253(22)00047-4 (2022).","journal-title":"Lancet Gastroenterol. Hepatol."},{"issue":"1","key":"54332_CR25","doi-asserted-by":"publisher","first-page":"138","DOI":"10.5217\/ir.2017.15.1.138","volume":"15","author":"P Singh","year":"2017","unstructured":"Singh, P., Ananthakrishnan, A. & Ahuja, V. Pivot to Asia: Inflammatory bowel disease burden. Intest. Res. 15(1), 138\u2013141. https:\/\/doi.org\/10.5217\/ir.2017.15.1.138 (2017).","journal-title":"Intest. Res."},{"issue":"7","key":"54332_CR26","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000024729","volume":"100","author":"F Juliao-Ba\u00f1os","year":"2021","unstructured":"Juliao-Ba\u00f1os, F. et al. Trends in the epidemiology of inflammatory bowel disease in Colombia by demographics and region using a nationally representative claims database and characterization of inflammatory bowel disease phenotype in a case series of Colombian patients. Medicine (Baltimore) 100(7), e24729. https:\/\/doi.org\/10.1097\/MD.0000000000024729 (2021).","journal-title":"Medicine (Baltimore)"},{"issue":"3","key":"54332_CR27","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1007\/s10198-017-0896-4","volume":"19","author":"R de SB Fr\u00f3es","year":"2018","unstructured":"de SB Fr\u00f3es, R. et al. The socio-economic impact of work disability due to inflammatory bowel disease in Brazil. Eur. J. Health Econ. 19(3), 463\u2013470. https:\/\/doi.org\/10.1007\/s10198-017-0896-4 (2018).","journal-title":"Eur. J. Health Econ."},{"issue":"3","key":"54332_CR28","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1590\/S0004-2803.201800000-73","volume":"55","author":"VG N\u00f3brega","year":"2018","unstructured":"N\u00f3brega, V. G. et al. THE onset of clinical manifestations in inflammatory bowel disease patients. Arq. Gastroenterol. 55(3), 290\u2013295. https:\/\/doi.org\/10.1590\/S0004-2803.201800000-73 (2018).","journal-title":"Arq. Gastroenterol."},{"issue":"9","key":"54332_CR29","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1093\/ecco-jcc\/jjv099","volume":"9","author":"Z Vegh","year":"2015","unstructured":"Vegh, Z. et al. Treatment steps, surgery, and hospitalization rates during the first year of follow-up in patients with inflammatory bowel diseases from the 2011 ECCO-Epicom inception cohort. J. Crohns Colitis 9(9), 747\u2013753. https:\/\/doi.org\/10.1093\/ecco-jcc\/jjv099 (2015).","journal-title":"J. Crohns Colitis"},{"issue":"11","key":"54332_CR30","doi-asserted-by":"publisher","first-page":"423","DOI":"10.2147\/CEG.S176583","volume":"30","author":"RG Gasparini","year":"2018","unstructured":"Gasparini, R. G., Sassaki, L. Y. & Saad-Hossne, R. Inflammatory bowel disease epidemiology in S\u00e3o Paulo State, Brazil. Clin. Exp. Gastroenterol. 30(11), 423\u2013429. https:\/\/doi.org\/10.2147\/CEG.S176583 (2018).","journal-title":"Clin. Exp. Gastroenterol."},{"issue":"1","key":"54332_CR31","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s12876-018-0822-y","volume":"18","author":"A Lima Martins","year":"2018","unstructured":"Lima Martins, A., Volpato, R. A. & Zago-Gomes, M. D. P. The prevalence and phenotype in Brazilian patients with inflammatory bowel disease. BMC Gastroenterol. 18(1), 87. https:\/\/doi.org\/10.1186\/s12876-018-0822-y (2018).","journal-title":"BMC Gastroenterol."},{"issue":"4","key":"54332_CR32","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.3748\/wjg.v21.i4.1197","volume":"21","author":"JM Parente","year":"2015","unstructured":"Parente, J. M. et al. Inflammatory bowel disease in an underdeveloped region of Northeastern Brazil. World J. Gastroenterol. 21(4), 1197\u20131206. https:\/\/doi.org\/10.3748\/wjg.v21.i4.1197 (2015).","journal-title":"World J. Gastroenterol."},{"issue":"14","key":"54332_CR33","doi-asserted-by":"publisher","first-page":"91","DOI":"10.2147\/CEG.S288688","volume":"17","author":"TNF Gomes","year":"2021","unstructured":"Gomes, T. N. F., de Azevedo, F. S., Argollo, M., Miszputen, S. J. & Ambrogini, O. Jr. Clinical and demographic profile of inflammatory bowel disease patients in a reference center of S\u00e3o Paulo, Brazil. Clin. Exp. Gastroenterol. 17(14), 91\u2013102. https:\/\/doi.org\/10.2147\/CEG.S288688 (2021).","journal-title":"Clin. Exp. Gastroenterol."},{"key":"54332_CR34","unstructured":"Website Ag\u00eancia Nacional da Sa\u00fade (ANS) [Internet]. Available from: https:\/\/www.ans.gov.br\/images\/stories\/Materiais_para_pesquisa\/Perfil_setor\/sala-de-situacao.html"},{"issue":"2","key":"54332_CR35","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.gtc.2012.01.008","volume":"41","author":"W Blonski","year":"2012","unstructured":"Blonski, W., Buchner, A. M. & Lichtenstein, G. R. Clinical predictors of aggressive\/disabling disease: Ulcerative colitis and Crohn disease. Gastroenterol. Clin. N. Am. 41(2), 443\u2013462. https:\/\/doi.org\/10.1016\/j.gtc.2012.01.008 (2012).","journal-title":"Gastroenterol. Clin. N. Am."},{"issue":"2","key":"54332_CR36","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/ajg.2008.38","volume":"104","author":"MJ Romberg-Camps","year":"2009","unstructured":"Romberg-Camps, M. J. et al. Influence of phenotype at diagnosis and of other potential prognostic factors on the course of inflammatory bowel disease. Am. J. Gastroenterol. 104(2), 371\u2013383. https:\/\/doi.org\/10.1038\/ajg.2008.38 (2009).","journal-title":"Am. J. Gastroenterol."},{"issue":"1","key":"54332_CR37","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgast-2022-001016","volume":"9","author":"CDSB Sacramento","year":"2022","unstructured":"Sacramento, C. D. S. B. et al. Variables associated with progression of moderate-to-severe Crohn\u2019s disease. BMJ Open Gastroenterol. 9(1), e001016. https:\/\/doi.org\/10.1136\/bmjgast-2022-001016 (2022).","journal-title":"BMJ Open Gastroenterol."},{"issue":"35","key":"54332_CR38","doi-asserted-by":"publisher","first-page":"7868","DOI":"10.3748\/wjg.v22.i35.7868","volume":"22","author":"JW Harper","year":"2016","unstructured":"Harper, J. W. & Zisman, T. L. Interaction of obesity and inflammatory bowel disease. World J. Gastroenterol. 22(35), 7868\u20137881. https:\/\/doi.org\/10.3748\/wjg.v22.i35.7868 (2016).","journal-title":"World J. Gastroenterol."},{"issue":"3","key":"54332_CR39","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1590\/S0004-2803.201700000-37","volume":"54","author":"PG Kotze","year":"2017","unstructured":"Kotze, P. G. Obesity and Crohn\u2019s disease: What comes first, the egg or the chicken?. Arq. Gastroenterol. 54(3), 268. https:\/\/doi.org\/10.1590\/S0004-2803.201700000-37 (2017).","journal-title":"Arq. Gastroenterol."},{"issue":"2","key":"54332_CR40","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1080\/19490976.2016.1270811","volume":"8","author":"KB Martinez","year":"2017","unstructured":"Martinez, K. B., Leone, V. & Chang, E. B. Western diets, gut dysbiosis, and metabolic diseases: Are they linked?. Gut Microbes 8(2), 130\u2013142. https:\/\/doi.org\/10.1080\/19490976.2016.1270811 (2017).","journal-title":"Gut Microbes"},{"issue":"6","key":"54332_CR41","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1017\/S1368980019002854","volume":"23","author":"SL Canhada","year":"2020","unstructured":"Canhada, S. L. et al. Ultra-processed foods, incident overweight and obesity, and longitudinal changes in weight and waist circumference: The Brazilian longitudinal study of adult health (ELSA-Brasil). Public Health Nutr. 23(6), 1076\u20131086. https:\/\/doi.org\/10.1017\/S1368980019002854 (2020).","journal-title":"Public Health Nutr."},{"issue":"67","key":"54332_CR42","doi-asserted-by":"publisher","first-page":"1605178","DOI":"10.3389\/ijph.2022.1605178","volume":"8","author":"ML Louzada","year":"2022","unstructured":"Louzada, M. L., Steele, E. M., Rezende, L. F. M., Levy, R. B. & Monteiro, C. A. Corrigendum: Changes in obesity prevalence attributable to ultra-processed food consumption in Brazil between 2002 and 2009. Int. J. Public Health 8(67), 1605178. https:\/\/doi.org\/10.3389\/ijph.2022.1605178 (2022).","journal-title":"Int. J. Public Health"},{"issue":"4","key":"54332_CR43","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1590\/S0004-2803.202000000-77","volume":"57","author":"EG Vilela","year":"2020","unstructured":"Vilela, E. G. et al. inflammatory bowel disease care in Brazil: How it is performed, obstacles and demands from the physicians\u2019 perspective. Arq. Gastroenterol. 57(4), 416\u2013427. https:\/\/doi.org\/10.1590\/S0004-2803.202000000-77 (2020).","journal-title":"Arq. Gastroenterol."},{"issue":"8","key":"54332_CR44","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.3748\/wjg.v29.i8.1330","volume":"29","author":"AL Martins","year":"2023","unstructured":"Martins, A. L. et al. Intestinal complications in Brazilian patients with ulcerative colitis treated with conventional therapy between 2011 and 2020. World J. Gastroenterol. 29(8), 1330\u20131343. https:\/\/doi.org\/10.3748\/wjg.v29.i8.1330 (2023).","journal-title":"World J. Gastroenterol."},{"key":"54332_CR45","doi-asserted-by":"publisher","first-page":"359130","DOI":"10.1155\/2015\/359130","volume":"2015","author":"BC da Silva","year":"2015","unstructured":"da Silva, B. C. et al. The demographic and clinical characteristics of ulcerative colitis in a Northeast Brazilian population. Biomed. Res. Int. 2015, 359130. https:\/\/doi.org\/10.1155\/2015\/359130 (2015).","journal-title":"Biomed. Res. Int."},{"issue":"2","key":"54332_CR46","doi-asserted-by":"publisher","first-page":"208","DOI":"10.3748\/wjg.v27.i2.208","volume":"27","author":"C Zaltman","year":"2021","unstructured":"Zaltman, C. et al. Real-world disease activity and sociodemographic, clinical and treatment characteristics of moderate-to-severe inflammatory bowel disease in Brazil. World J. Gastroenterol. 27(2), 208\u2013223. https:\/\/doi.org\/10.3748\/wjg.v27.i2.208 (2021).","journal-title":"World J. Gastroenterol."},{"issue":"4","key":"54332_CR47","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1038\/s41424-018-0013-8","volume":"9","author":"AR Andrade","year":"2018","unstructured":"Andrade, A. R. et al. Risk of thrombosis and mortality in inflammatory bowel disease. Clin. Transl. Gastroenterol. 9(4), 142. https:\/\/doi.org\/10.1038\/s41424-018-0013-8 (2018).","journal-title":"Clin. Transl. Gastroenterol."},{"issue":"1","key":"54332_CR48","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1590\/s0004-28032009000100009","volume":"46","author":"CR Victoria","year":"2009","unstructured":"Victoria, C. R., Sassak, L. Y. & Nunes, H. R. Incidence and prevalence rates of inflammatory bowel diseases, in midwestern of S\u00e3o Paulo State, Brazil. Arq. Gastroenterol. 46(1), 20\u201325. https:\/\/doi.org\/10.1590\/s0004-28032009000100009 (2009).","journal-title":"Arq. Gastroenterol."},{"issue":"9","key":"54332_CR49","doi-asserted-by":"publisher","first-page":"2925","DOI":"10.1007\/s10620-020-06646-z","volume":"66","author":"R de S\u00e1 Brito Fr\u00f3es","year":"2021","unstructured":"de S\u00e1 Brito Fr\u00f3es, R. et al. Prevalence, indirect costs, and risk factors for work disability in patients with Crohn\u2019s disease at a tertiary care center in Rio de Janeiro. Dig. Dis. Sci. 66(9), 2925\u20132934. https:\/\/doi.org\/10.1007\/s10620-020-06646-z (2021).","journal-title":"Dig. Dis. Sci."},{"key":"54332_CR50","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjad048","author":"LMG de Codes","year":"2023","unstructured":"de Codes, L. M. G. et al. Anorectal function and clinical characteristics associated with fecal incontinence in patients with Crohn\u2019s disease. J. Crohns Colitis https:\/\/doi.org\/10.1093\/ecco-jcc\/jjad048 (2023).","journal-title":"J. Crohns Colitis"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-54332-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-54332-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-54332-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T15:09:05Z","timestamp":1708528145000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-54332-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,21]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["54332"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-54332-1","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,21]]},"assertion":[{"value":"8 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Renata de S\u00e1 Brito Fr\u00f3es\u2014Received lecture fee[s] from AbbVie, Janssen, Takeda, Ferring and Pfizer; is advisory committee member for Janssen and Takeda; Adriana Ribas Andrade\u2014Received lecture fee[s] from AbbVie, Janssen; Mikaell Alexandre Gouvea Faria\u2014Received lecture fee[s] from AbbVie, Janssen, Takeda, Nestl\u00e9, advisory committee member for Janssen; Rog\u00e9rio Serafim Parra\u2014Received lecture fee[s] from AbbVie, Janssen, Takeda, and Pfizer; is advisory committee member for Janssen and AbbVie; Cyrla Zaltman\u2014Received lecture fee[s] from Janssen, Takeda, Celltrion, Pfizer; Carlos Henrique Marques dos Santos\u2014Received lecture fee[s] from AbbVie, Janssen, Takeda; Mauro Bafutto\u2014Received lecture fee[s] from AbbVie, Janssen, Takeda; Abel Botelho Quaresma\u2014Received lecture fee[s] from AbbVie, Janssen; Genoile Oliveira Santana\u2014Received lecture fee[s] from AbbVie, Janssen, Takeda, Ferring and Pfizer; is advisory committee member for Janssen; Rafael Lu\u00eds Luporini\u2014Received lecture fee[s] from AbbVie, Janssen, Takeda; Mardem Machado de Souza\u2014Received lecture fee[s] from AbbVie, Janssen, Takeda; Ligia Yukie Sassaki\u2014Received lecture fee[s] from Janssen; Rogerio Saad-Hossne\u2014Received lecture fee[s] and advisory committee member for AbbVie, Takeda, Janssen, Pfizer, Fresenius and Amgen. Heitor Siffert Pereira de Souza, S\u00e9rgio Figueiredo de Lima Junior, Sender Jankiel Miszputen, Giedre Soares Prates Herrerias, Roberto Luiz Kaiser Junior, Catiane Rios do Nascimento, Omar F\u00e9res, Jaqueline Ribeiro de Barros\u2014No potential conflict of interest to disclose.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"4314"}}