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The present study aimed to assess the early orthodontic treatment need among children with mixed dentition in the Eastern Saudi Arabia. A descriptive cross-sectional study was conducted among Saudi children visiting the outpatient clinics in a University dental setting, and data were collected based on Index for preventive and interceptive orthodontic need (IPION). Descriptive statistics, chi-square test and Fisher\u2019s exact test were used for data analysis with statistical significance set at p\u2009&lt;\u20090.05. The category of \u2018no treatment need\u2019 accounted for 11.3% while \u2018moderate treatment need\u2019 and \u2018definite treatment need\u2019 categories accounted for 29.3% and 59.4% respectively. There was no statistical difference between males and females in the distribution of the three categories of treatment need (p\u2009=\u20090.513). This study demonstrated a very high need for early orthodontic treatment among Saudi children in the mixed dentition stage. Emphasis should be placed on increased awareness and benefits of seeking early orthodontic treatment involving preventive and interceptive procedures in the mixed dentition.<\/jats:p>","DOI":"10.1038\/s41598-024-54381-6","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T12:03:32Z","timestamp":1708344212000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["An epidemiological study on early orthodontic treatment need among eastern Saudi Arabian children in the mixed dentition stage"],"prefix":"10.1038","volume":"14","author":[{"given":"Guna Shekhar","family":"Madiraju","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousef Majed","family":"Almugla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohini","family":"Mohan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basil Mohammed","family":"Alnasser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,19]]},"reference":[{"key":"54381_CR1","unstructured":"Coetzee, C. 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