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An association has been reported between dental caries and\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection. As antimicrobial agents are less effective inside dental caries because of impaired blood circulation, the presence of untreated dental caries (decayed teeth) may influence the success of\n                    <jats:italic>H. pylori<\/jats:italic>\n                    eradication treatment. In this cross-sectional study, we examined whether failed eradication of\n                    <jats:italic>H. pylori<\/jats:italic>\n                    was associated with decayed teeth in Japanese adults. Enrolled were 226 participants who received dental checkups among those treated for eradication of\n                    <jats:italic>H. pylori<\/jats:italic>\n                    at Asahi University Hospital between April 2019 and March 2021. Treatment efficacy was assessed by urea breath test. Eradication failed in 38 participants (17%), decayed teeth in 32 participants (14%), and number of 0.34 teeth per participants. Multivariate logistic regression analyses showed that failed eradication of\n                    <jats:italic>H. pylori<\/jats:italic>\n                    was associated with decayed teeth (presence: odds ratio, 2.672; 95% confidence interval, 1.093\u20136.531) after adjusting for gender, age, and brushing frequency. These results indicate that failed eradication of\n                    <jats:italic>H. pylori<\/jats:italic>\n                    was associated with decayed teeth and suggest that untreated dental caries may impact treatment for eradication of\n                    <jats:italic>H. pylori<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1038\/s41598-024-54757-8","type":"journal-article","created":{"date-parts":[[2024,2,18]],"date-time":"2024-02-18T23:12:48Z","timestamp":1708297968000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association between failed eradication of 7-day triple therapy for Helicobacter pylori and untreated dental caries in Japanese adults"],"prefix":"10.1038","volume":"14","author":[{"given":"Komei","family":"Iwai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuji","family":"Azuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takatoshi","family":"Yonenaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Sasai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutoshi","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Obora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiko","family":"Deguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5608-7430","authenticated-orcid":false,"given":"Takaaki","family":"Tomofuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,19]]},"reference":[{"key":"54757_CR1","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1016\/S0140-6736(84)91816-6","volume":"323","author":"B Marshall","year":"1984","unstructured":"Marshall, B. & Warren, J. 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