{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:32:14Z","timestamp":1792791134954,"version":"4.5.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"federal Ministry of Education and Research in Germany","award":["16KN062022"],"award-info":[{"award-number":["16KN062022"]}],"id":[{"id":"https:\/\/ror.org\/04pz7b180","id-type":"ROR","asserted-by":"crossref"}]},{"name":"federal Ministry of Education and Research in Germany","award":["16KN062022"],"award-info":[{"award-number":["16KN062022"]}],"id":[{"id":"https:\/\/ror.org\/04pz7b180","id-type":"ROR","asserted-by":"crossref"}]},{"name":"federal Ministry of Education and Research in Germany","award":["16KN062022"],"award-info":[{"award-number":["16KN062022"]}],"id":[{"id":"https:\/\/ror.org\/04pz7b180","id-type":"ROR","asserted-by":"crossref"}]},{"name":"federal Ministry of Education and Research in Germany","award":["16KN062022"],"award-info":[{"award-number":["16KN062022"]}],"id":[{"id":"https:\/\/ror.org\/04pz7b180","id-type":"ROR","asserted-by":"crossref"}]},{"name":"federal Ministry of Education and Research in Germany","award":["16KN062022"],"award-info":[{"award-number":["16KN062022"]}],"id":[{"id":"https:\/\/ror.org\/04pz7b180","id-type":"ROR","asserted-by":"crossref"}]},{"name":"federal Ministry of Education and Research in Germany","award":["16KN062022"],"award-info":[{"award-number":["16KN062022"]}],"id":[{"id":"https:\/\/ror.org\/04pz7b180","id-type":"ROR","asserted-by":"crossref"}]},{"name":"federal Ministry of Education and Research in Germany","award":["16KN062022"],"award-info":[{"award-number":["16KN062022"]}],"id":[{"id":"https:\/\/ror.org\/04pz7b180","id-type":"ROR","asserted-by":"crossref"}]},{"name":"federal Ministry of Education and Research in Germany","award":["16KN062022"],"award-info":[{"award-number":["16KN062022"]}],"id":[{"id":"https:\/\/ror.org\/04pz7b180","id-type":"ROR","asserted-by":"crossref"}]},{"name":"federal Ministry of Education and Research in Germany","award":["16KN062022"],"award-info":[{"award-number":["16KN062022"]}],"id":[{"id":"https:\/\/ror.org\/04pz7b180","id-type":"ROR","asserted-by":"crossref"}]},{"name":"federal Ministry of Education and Research in Germany","award":["16KN062022"],"award-info":[{"award-number":["16KN062022"]}],"id":[{"id":"https:\/\/ror.org\/04pz7b180","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004168","name":"Universit\u00e4t zu L\u00fcbeck","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004168","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To carry out the preclinical and histological evaluation of a novel nanotechnology-based microshunt for drainage glaucoma surgery. Twelve New Zealand White rabbits were implanted with a novel microshunt and followed up for 6\u00a0weeks. The new material composite consists of the silicone polydimethylsiloxane (PDMS) and tetrapodal Zinc Oxide (ZnO-T) nano-\/microparticles. The microshunts were inserted ab externo to connect the subconjunctival space with the anterior chamber. Animals were euthanized after 2 and 6\u00a0weeks for histological evaluation. Ocular health and implant position were assessed at postoperative days 1, 3, 7 and twice a week thereafter by slit lamp biomicroscopy. Intraocular pressure (IOP) was measured using rebound tonometry. A good tolerability was observed in both short- and medium-term follow-up. Intraocular pressure was reduced following surgery but increased to preoperative levels after 2\u00a0weeks. No clinical or histological signs of inflammatory or toxic reactions were seen; the fibrotic encapsulation was barely noticeable after two weeks and very mild after six weeks. The new material composite PDMS\/ZnO-T is well tolerated and the associated foreign body fibrotic reaction quite mild. The new microshunt reduces the IOP for 2\u00a0weeks. Further research will elucidate a tube-like shape to improve and prolong outflow performance and longer follow-up to exclude medium-term adverse effects.<\/jats:p>","DOI":"10.1038\/s41598-024-54960-7","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T05:02:42Z","timestamp":1708664562000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["In vivo evaluation of a nanotechnology-based microshunt for filtering glaucoma surgery"],"prefix":"10.1038","volume":"14","author":[{"given":"Stefanie","family":"Gniesmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svenja Rebecca","family":"Sonntag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Gapeeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ala","family":"Cojocaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f6ren","family":"Kaps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Adelung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Sewing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayseg\u00fcl","family":"Tura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Grisanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swaantje","family":"Grisanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,23]]},"reference":[{"key":"54960_CR1","doi-asserted-by":"publisher","first-page":"495","DOI":"10.4103\/ijo.IJO_1130_17","volume":"66","author":"R Sihota","year":"2018","unstructured":"Sihota, R., Angmo, D., Ramaswamy, D. & Dada, T. Simplifying, \u201ctarget\u201d intraocular pressure for different stages of primary open-angle glaucoma and primary angle-closure glaucoma. Indian J. Ophthalmol. 66, 495\u2013505 (2018).","journal-title":"Indian J. Ophthalmol."},{"key":"54960_CR2","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1186\/s13063-015-0924-6","volume":"16","author":"EL Lamoureux","year":"2015","unstructured":"Lamoureux, E. L. et al. Comparing the effectiveness of selective laser trabeculoplasty with topical medication as initial treatment (the Glaucoma Initial Treatment Study): Study protocol for a randomised controlled trial. Trials 16, 406 (2015).","journal-title":"Trials"},{"key":"54960_CR3","doi-asserted-by":"crossref","unstructured":"European Glaucoma Society Terminology and Guidelines for Glaucoma, 5th Edition. Br. J. Ophthalmol. 105, 1\u2013169 (2021).","DOI":"10.1136\/bjophthalmol-2021-egsguidelines"},{"key":"54960_CR4","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/aos.14485","volume":"99","author":"RS Chong","year":"2021","unstructured":"Chong, R. S., Crowston, J. G. & Wong, T. T. Experimental models of glaucoma filtration surgery. Acta Ophthalmol. 99, 9\u201315 (2021).","journal-title":"Acta Ophthalmol."},{"key":"54960_CR5","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1159\/000458485","volume":"59","author":"AA Aref","year":"2017","unstructured":"Aref, A. A., Gedde, S. J. & Budenz, D. L. Glaucoma drainage implant surgery. Dev. Ophthalmol. 59, 43\u201352 (2017).","journal-title":"Dev. Ophthalmol."},{"key":"54960_CR6","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.preteyeres.2009.06.004","volume":"28","author":"D-Y Yu","year":"2009","unstructured":"Yu, D.-Y. et al. The critical role of the conjunctiva in glaucoma filtration surgery. Prog. Retinal Eye Res. 28, 303\u2013328 (2009).","journal-title":"Prog. Retinal Eye Res."},{"key":"54960_CR7","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1080\/09205063.2021.1946460","volume":"32","author":"X Zhao","year":"2021","unstructured":"Zhao, X., Liu, S., Han, Y., Wang, Y. & Lin, Q. Preparation of 5-fluorouracil loaded chitosan microtube via in situ precipitation for glaucoma drainage device application: In vitro and in vivo investigation. J. Biomater. Sci. Polym. Ed. 32, 1849\u20131864 (2021).","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"54960_CR8","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1097\/IJG.0b013e31815c89b9","volume":"16","author":"OG Koz","year":"2007","unstructured":"Koz, O. G. et al. The effect of paclitaxel on conjunctival wound healing: a pilot study. J. Glaucoma 16, 610\u2013615 (2007).","journal-title":"J. Glaucoma"},{"key":"54960_CR9","doi-asserted-by":"crossref","unstructured":"Takeuchi, K. et al. Solid hyaluronic acid film and the prevention of postoperative fibrous scar formation in experimental animal eyes. Arch Ophthalmol. (Chicago, Ill. : 1960) 127, 460\u2013464 (2009).","DOI":"10.1001\/archophthalmol.2009.70"},{"key":"54960_CR10","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1159\/000509135","volume":"64","author":"K Ishida","year":"2021","unstructured":"Ishida, K. et al. Evaluation of bleb characteristics after trabeculectomy and glaucoma implant surgery in the rabbit. Ophthal. Res. 64, 68\u201376 (2021).","journal-title":"Ophthal. Res."},{"key":"54960_CR11","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1167\/tvst.11.8.29","volume":"11","author":"RJS van Mechelen","year":"2022","unstructured":"van Mechelen, R. J. S. et al. Wound healing response after bleb-forming glaucoma surgery with a SIBS microshunt in rabbits. Translat. Vis. Sci. Technol. 11, 29 (2022).","journal-title":"Translat. Vis. Sci. Technol."},{"key":"54960_CR12","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1080\/08820538.2019.1581820","volume":"34","author":"A Chatzara","year":"2019","unstructured":"Chatzara, A., Chronopoulou, I., Theodossiadis, G., Theodossiadis, P. & Chatziralli, I. XEN implant for glaucoma treatment: A review of the literature. Semin. Ophthalmol. 34, 93\u201397 (2019).","journal-title":"Semin. Ophthalmol."},{"key":"54960_CR13","doi-asserted-by":"crossref","unstructured":"Sonntag, S. R. et al. Zinc Oxide tetrapods modulate wound healing and cytokine release in vitro-a new antiproliferative substance in glaucoma filtering surgery. Life (Basel, Switzerland) 12 (2022).","DOI":"10.3390\/life12111691"},{"key":"54960_CR14","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1021\/acsbiomaterials.2c01203","volume":"9","author":"A Gapeeva","year":"2023","unstructured":"Gapeeva, A. et al. Tetrapodal ZnO-based composite stents for minimally invasive glaucoma surgery. ACS Biomater. Sci. Eng. 9, 1352\u20131361 (2023).","journal-title":"ACS Biomater. Sci. Eng."},{"key":"54960_CR15","doi-asserted-by":"publisher","first-page":"105212","DOI":"10.1016\/j.tiv.2021.105212","volume":"76","author":"M Ceresnakova","year":"2021","unstructured":"Ceresnakova, M., Dully, M., Murray, D., Soulimane, T. & Hudson, S. P. Stent conditioned media for in vitro evaluation of hydrophobic stent coatings. Toxicol. Vitro: Int. J. Publ. Assoc. BIBRA 76, 105212 (2021).","journal-title":"Toxicol. Vitro: Int. J. Publ. Assoc. BIBRA"},{"key":"54960_CR16","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1167\/tvst.10.9.9","volume":"10","author":"T Fujimoto","year":"2021","unstructured":"Fujimoto, T. et al. Intraocular pressure-lowering effects of trabeculectomy versus microshunt insertion in rabbit eyes. Translat. Vis. Sci. Technol. 10, 9 (2021).","journal-title":"Translat. Vis. Sci. Technol."},{"key":"54960_CR17","doi-asserted-by":"crossref","unstructured":"Sonntag, S. R. et al. In vitro evaluation of zinc oxide tetrapods as a new material component for glaucoma implants. Life (Basel, Switzerland) 12 (2022).","DOI":"10.3390\/life12111805"},{"key":"54960_CR18","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1167\/tvst.11.4.9","volume":"11","author":"K Nakamura","year":"2022","unstructured":"Nakamura, K. et al. Tissue reactivity to, and stability of, glaucoma drainage device materials placed under rabbit conjunctiva. Translat. Vis. Sci. Technol. 11, 9 (2022).","journal-title":"Translat. Vis. Sci. Technol."},{"key":"54960_CR19","doi-asserted-by":"crossref","unstructured":"Acosta, A. C. et al. A newly designed glaucoma drainage implant made of poly(styrene-b-isobutylene-b-styrene): Biocompatibility and function in normal rabbit eyes. Archives of ophthalmology (Chicago, Ill. : 1960) 124, 1742\u20131749 (2006).","DOI":"10.1001\/archopht.124.12.1742"},{"key":"54960_CR20","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1007\/s00347-018-0669-1","volume":"115","author":"M Lenzhofer","year":"2018","unstructured":"Lenzhofer, M., Hohensinn, M., Strohmaier, C. & Reitsamer, H. A. Subkonjunktivale minimalinvasive Glaukomchirurgie: Verfahren und klinische Ergebnisse. Der Ophthalmologe\u202f: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 115, 381\u2013387 (2018).","journal-title":"Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft"},{"key":"54960_CR21","doi-asserted-by":"crossref","unstructured":"Fea, A. M. et al. Early experience with the New XEN63 implant in primary open-angle glaucoma patients: Clinical outcomes. J. Clin. Med. 10 (2021).","DOI":"10.3390\/jcm10081628"},{"key":"54960_CR22","doi-asserted-by":"publisher","first-page":"3594","DOI":"10.1167\/iovs.16-19453","volume":"57","author":"TS Shute","year":"2016","unstructured":"Shute, T. S. et al. Biocompatibility of a novel microfistula implant in nonprimate mammals for the surgical treatment of glaucoma. Invest. Ophthalmol. Vis. Sci. 57, 3594\u20133600 (2016).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"54960_CR23","doi-asserted-by":"publisher","first-page":"e433","DOI":"10.1111\/aos.14602","volume":"99","author":"LMJ Scheres","year":"2021","unstructured":"Scheres, L. M. J. et al. XEN\u00ae Gel Stent compared to PRESERFLO\u2122 MicroShunt implantation for primary open-angle glaucoma: two-year results. Acta Ophthalmol. 99, e433\u2013e440 (2021).","journal-title":"Acta Ophthalmol."},{"key":"54960_CR24","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1167\/tvst.8.3.58","volume":"8","author":"RMH Lee","year":"2019","unstructured":"Lee, R. M. H., Bouremel, Y., Eames, I., Brocchini, S. & Khaw, P. T. The implications of an ab interno versus ab externo surgical approach on outflow resistance of a subconjunctival drainage device for intraocular pressure control. Translat. Vis. Sci. Technol. 8, 58 (2019).","journal-title":"Translat. Vis. Sci. Technol."},{"key":"54960_CR25","doi-asserted-by":"crossref","unstructured":"Garc\u00eda Feijo\u00f3, J. et al. A European study of the performance and safety of MINIject in patients with medically uncontrolled open-angle glaucoma (STAR-II). J. Glaucoma 29, 864\u2013871 (2020).","DOI":"10.1097\/IJG.0000000000001632"},{"key":"54960_CR26","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s42490-020-00045-1","volume":"2","author":"I Grierson","year":"2020","unstructured":"Grierson, I. et al. A novel suprachoroidal microinvasive glaucoma implant: in vivo biocompatibility and biointegration. BMC Biomed. Eng. 2, 10 (2020).","journal-title":"BMC Biomed. Eng."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-54960-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-54960-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-54960-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T05:06:18Z","timestamp":1708664778000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-54960-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,23]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["54960"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-54960-7","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,23]]},"assertion":[{"value":"22 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"4452"}}