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The present study aims to investigate the potential influences of the non-invasive transcutaneous electrical nerve stimulation (TENS) on multiple non-compressible internal organs\u2019 blood flow. Porcine animal model (n\u2009=\u20098) was randomized for a total of 48 neuromodulation sessions with two different TENS stimulation frequencies (80\u00a0Hz, 10\u00a0Hz) and a placebo stimulation. A combination of two different electrode configurations (Abdominal-only or Abdominal and hind limb) were also performed. Intraarterial blood flow measurements were taken during pre and post-stimulation periods at the left renal artery, common hepatic artery, and left coronary artery. Intracranial, and extracranial arterial blood flows were also assessed with digital subtraction angiography. TENS with abdominal-only electrode configurations at 10\u00a0Hz demonstrated significant reductions in average peak blood flow velocity (APV) of the common hepatic artery (p\u2009=\u20090.0233) and renal arteries (p\u2009=\u20090.0493). Arterial pressures (p\u2009=\u20090.0221) were also significantly lower when renal APV was reduced. The outcome of the present study emphasises the potential use of TENS in decreasing the blood flow of non-compressible internal organs when the correct combination of electrodes configuration and frequency is used.<\/jats:p>","DOI":"10.1038\/s41598-024-55165-8","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T09:02:28Z","timestamp":1714640548000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Decreasing the blood flow of non-compressible intra-abdominal organs with non-invasive transcutaneous electrical stimulation"],"prefix":"10.1038","volume":"14","author":[{"given":"Yusuf O.","family":"Cakmak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prashanna","family":"Khwaounjoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Pangilinan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Innes K.","family":"Wise","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Burrows","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pranish","family":"Kolakshyapati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoe","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Bannon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,5,2]]},"reference":[{"key":"55165_CR1","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.autneu.2003.08.006","volume":"108","author":"E Stener-Victorin","year":"2003","unstructured":"Stener-Victorin, E., Kobayashi, R. & Kurosawa, M. 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Cakmak is a shareholder in Stoparkinson LLC, US. He holds numerous patents for wearables and mhealth including non-invasive neuromodulation of internal organ blood flow. Present study is partially supported by Inventram which is the technology transfer company of the Koc University that holds Yusuf O. Cakmak\u2019s patents for non-invasive internal organ\u2019s blood flow modulation. The other authors do not have any competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"10122"}}