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This study aims to assess the carcinogenic and non-carcinogenic health risks associated with metals in Isfahan drinking water. Eighty water samples were randomly collected from the city's distribution network between January and March 2020\u20132021. Inductively coupled plasma Optical Emission Spectrometry was used to measure toxic metals, namely Pb, Cr, Cd, Ni, and As concentrations. Results revealed that the mean concentration of Ni (70.03\u00a0\u00b5g\/L) exceeded the WHO reference value (70\u00a0\u00b5g\/L), while the other metals were below the standard values. The average chronic daily intake order of toxic metals was Ni\u2009&gt;\u2009Cr\u2009&gt;\u2009Pb\u2009&gt;\u2009As\u2009&gt;\u2009Cd. Non-carcinogenic risk assessment through hazard quotient (HQ) and hazard index (HI) demonstrated that both THI for adults (HQ\n                    <jats:sub>ingestion<\/jats:sub>\n                    \u2009+\u2009HQ\n                    <jats:sub>dermal<\/jats:sub>\n                    \u2009=\u20094.02E\u221203) and THI for children (HI\n                    <jats:sub>ingestion<\/jats:sub>\n                    \u2009+\u2009HI\n                    <jats:sub>dermal<\/jats:sub>\n                    \u2009=\u20093.83E\u221203) were below the acceptable limit (less than 1). This indicated no non-carcinogenic risk to residents through water ingestion or dermal exposure. However, findings indicated that the ingestion route was the primary exposure pathway, with HQ values for ingestion exceeding HQ values for dermal adsorption. Carcinogenic risk assessment showed that the risk associated with As metal exceeded the acceptable limit (1\u2009\u00d7\u200910\n                    <jats:sup>\u22126<\/jats:sup>\n                    ). Therefore, implementing treatment improvement programs and appropriate control measures is essential to safeguard the health of Isfahan City residents.\n                  <\/jats:p>","DOI":"10.1038\/s41598-024-55615-3","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T12:03:04Z","timestamp":1709208184000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Assessing the carcinogenic and non-carcinogenic health risks of metals in the drinking water of Isfahan, Iran"],"prefix":"10.1038","volume":"14","author":[{"given":"Maryam","family":"Moradnia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein Movahedian","family":"Attar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaghoub","family":"Hajizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Lundh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Salari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Darvishmotevalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,29]]},"reference":[{"key":"55615_CR1","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s12011-018-1516-6","volume":"190","author":"HN Saleh","year":"2019","unstructured":"Saleh, H. 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