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In the present study, we evaluated the association of\n                    <jats:italic>cGAS<\/jats:italic>\n                    and\n                    <jats:italic>STING<\/jats:italic>\n                    gene expression levels and plasma IFN-\u03b1, TNF-\u03b1 and IL-6 levels with COVID-19 severity in acute infection and long COVID, based on analysis of blood samples from 148 individuals, 87 with acute COVID-19 and 61 in the post-COVID-19 period. Quantification of gene expression was performed by real-time PCR, and cytokine levels were quantified by ELISA and flow cytometry. In acute COVID-19,\n                    <jats:italic>cGAS<\/jats:italic>\n                    ,\n                    <jats:italic>STING<\/jats:italic>\n                    , IFN-\u03b1, TNF-\u03b1, and IL-6 levels were higher in patients with severe disease than in those with nonsevere manifestations (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Long COVID was associated with elevated\n                    <jats:italic>cGAS<\/jats:italic>\n                    ,\n                    <jats:italic>STING<\/jats:italic>\n                    and IFN-\u03b1 levels (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Activation of the cGAS-STING pathway may contribute to an intense systemic inflammatory state in severe COVID-19 and, after infection resolution, induce an autoinflammatory disease in some tissues, resulting in long COVID.\n                  <\/jats:p>","DOI":"10.1038\/s41598-024-55696-0","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T03:03:24Z","timestamp":1709175804000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Severe COVID-19 and long COVID are associated with high expression of STING, cGAS and IFN-\u03b1"],"prefix":"10.1038","volume":"14","author":[{"given":"Maria Alice Freitas","family":"Queiroz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wandrey Roberto dos Santos","family":"Brito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keise Adrielle 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