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The present research work was carried out to investigate the phytochemical constituents, antimicrobial activity, and antioxidant activity of different extracted samples of\n                    <jats:italic>Euphorbia parviflora<\/jats:italic>\n                    . Anti-microbial studies were carried out by Agar well diffusion while the DPPH method was employed for investigating anti-oxidant activity. Three samples from methanol, chloroform, and ethyl acetate extract were tested against five different bacterial strains comprising two species from Gram-positive bacteria i.e.,\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    and\n                    <jats:italic>Bacillus subtilis<\/jats:italic>\n                    and three species from Gram-negative bacteria i.e.\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    ,\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    and\n                    <jats:italic>Klebsiella pneumonia<\/jats:italic>\n                    along two fungal strains i.e.\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    and\n                    <jats:italic>Aspergillus niger.<\/jats:italic>\n                    The results of the qualitative phytochemical analysis showed that methanolic, chloroformic, and ethylacetate extract of\n                    <jats:italic>Euphorbia parviflora<\/jats:italic>\n                    consist of alkaloids, reducing sugars, flavonoids, terpenoids, tannins, and saponins. The total phenol and flavonoid content of\n                    <jats:italic>E. parviflora<\/jats:italic>\n                    showed that the methanolic extract of\n                    <jats:italic>E. parviflora<\/jats:italic>\n                    had a significantly higher total phenolic content (53.73\u2009\u00b1\u20090.30\u00a0mg of GAE\/g) and flavonoid content (44.62\u2009\u00b1\u20090.38\u00a0mg of than other extracts. The content of total phenolic and flavonoids was more in methanolic extract as compared to other extracts of\n                    <jats:italic>E. prolifera.<\/jats:italic>\n                    The HPLC analysis showed that in the chloroform extract of\n                    <jats:italic>E. parviflora<\/jats:italic>\n                    Cinnamic acid (4.32\u2009\u00b1\u20092.89\u00a0mg\/g) was dominant, in methanol extract quercetin (3.42\u2009\u00b1\u20092.89\u00a0mg\/g) was dominant and in ethyl acetate extract of\n                    <jats:italic>E. parviflora<\/jats:italic>\n                    catechin (4.44\u2009\u00b1\u20092.89\u00a0mg\/g) was found dominant. The antimicrobial activity revealed that amongst all the extracts the highest antibacterial activity was shown by methanolic extract against\n                    <jats:italic>B. subtilis<\/jats:italic>\n                    and\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    as compared to the other extracts. The antioxidant activity revealed that methanolic extract of\n                    <jats:italic>E. parviflora<\/jats:italic>\n                    demonstrated higher antioxidant activity (82.42\u2009\u00b1\u20090.02) followed by chloroform extract (76.48\u2009\u00b1\u20090.08) at 150\u00a0\u00b5g\/mL. The aim of this study was primarily to evaluate the potential of this plant as a reliable source of antimicrobials and antioxidants that may be used for the treatment of various infectious diseases in the future. The study provides evidence that this plant can act as a reliable source of antimicrobial and antioxidant agents and might be used against several infectious diseases.\n                  <\/jats:p>","DOI":"10.1038\/s41598-024-55905-w","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T09:04:13Z","timestamp":1709802253000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Phytochemical screening, HPLC analysis, antimicrobial and antioxidant effect of Euphorbia parviflora L. 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