{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:49:05Z","timestamp":1793407745776,"version":"4.5.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T00:00:00Z","timestamp":1710115200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T00:00:00Z","timestamp":1710115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This retrospective cohort study established malnutrition\u2019s impact on mortality and neurological recovery of older patients with cervical spinal cord injury (SCI). It included patients aged\u2009\u2265\u200965\u00a0years with traumatic cervical SCI treated conservatively or surgically. The Geriatric Nutritional Risk Index was calculated to assess nutritional-related risk. Overall, 789 patients (mean follow-up: 20.1\u00a0months) were examined and 47 had major nutritional-related risks on admission. One-year mortality rate, median survival time, neurological recovery, and activities of daily living (ADL) at 1\u00a0year post-injury were compared between patients with major nutrition-related risk and matched controls selected using 1:2 propensity score matching to adjust for age, pre-traumatic neurological impairment, and activity. In the Kaplan\u2013Meier analysis, the median survival times were 44.9 and 76.5\u00a0months for patients with major nutrition-related risk and matched controls, respectively (p\u2009=\u20090.015). Matched controls had more individuals with a neurological improvement of American Spinal Injury Association Impairment Scale\u2009\u2265\u20091 grade (p\u2009=\u20090.039) and independence in ADL at 1\u00a0year post-injury than patients with major nutrition-related risk (p\u2009&lt;\u20090.05). In conclusion, 6% of older patients with cervical SCI had major nutrition-related risks; they showed a significantly higher 1\u00a0year mortality rate, shorter survival time, poorer neurological improvement, and lower ADL at 1\u00a0year post-injury than matched controls.<\/jats:p>","DOI":"10.1038\/s41598-024-56527-y","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T04:13:09Z","timestamp":1710130389000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Impact of malnutrition on mortality and neurological recovery of older patients with spinal cord injury"],"prefix":"10.1038","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1467-2599","authenticated-orcid":false,"given":"Koji","family":"Tamai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetomi","family":"Terai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Yokogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Sasagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Segi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadayuki","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Funayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihiko","family":"Eto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Yamaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kota","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Yamane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeo","family":"Furuya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Yunde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiko","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Terashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Hirota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuaki","family":"Imajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shota","family":"Ikegami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Uehara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Tonomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munehiro","family":"Sakata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ko","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshito","family":"Onoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Kawaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Haruta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Uei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokatsu","family":"Sawada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Nakanishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Misaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiyoshi","family":"Kuroda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichiro","family":"Kakutani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Kakiuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhito","family":"Kiyasu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Tominaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Tokumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Iizuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Takasawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Akeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihiko","family":"Takegami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruki","family":"Funao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Oshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kaito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshitaka","family":"Yoshii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Ohba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bungo","family":"Otsuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"Seki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Ishihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Okada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Imagama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,11]]},"reference":[{"key":"56527_CR1","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1007\/s00586-014-3424-6","volume":"24","author":"SB Jazayeri","year":"2015","unstructured":"Jazayeri, S. B., Beygi, S., Shokraneh, F., Hagen, E. M. & Rahimi-Movaghar, V. Incidence of traumatic spinal cord injury worldwide: A systematic review. Eur. Spine J. 24, 905\u2013918 (2015).","journal-title":"Eur. Spine J."},{"key":"56527_CR2","unstructured":"World_Health_Organization. Spinal Cord Injury. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/spinal-cord-injury Accessed 9 March 2024 (2013)."},{"key":"56527_CR3","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1097\/BRS.0b013e31822e5ff8","volume":"37","author":"B Lenehan","year":"2012","unstructured":"Lenehan, B. et al. The epidemiology of traumatic spinal cord injury in British Columbia, Canada. Spine (Phila Pa 1976) 37, 321\u2013329 (2012).","journal-title":"Spine (Phila Pa 1976)"},{"key":"56527_CR4","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.apmr.2010.08.031","volume":"92","author":"MJ DeVivo","year":"2011","unstructured":"DeVivo, M. J. & Chen, Y. Trends in new injuries, prevalent cases, and aging with spinal cord injury. Arch. Phys. Med. Rehabil. 92, 332\u2013338 (2011).","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"56527_CR5","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1038\/s41393-020-00533-0","volume":"59","author":"N Miyakoshi","year":"2021","unstructured":"Miyakoshi, N. et al. A nationwide survey on the incidence and characteristics of traumatic spinal cord injury in Japan in 2018. Spinal Cord 59, 626\u2013634 (2021).","journal-title":"Spinal Cord"},{"key":"56527_CR6","unstructured":"World Health Organization. Vol. 2016. 7\u201311 World Health Statistic 2016. (World Health Organization, 2016). https:\/\/www.who.int\/docs\/defaultsource\/gho-documents\/world-health-statistic-reports\/world-heatlth-statistics-2016.pdf."},{"key":"56527_CR7","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1007\/s00586-021-06890-5","volume":"30","author":"SI AlEissa","year":"2021","unstructured":"AlEissa, S. I. et al. SPINE20 A global advocacy group promoting evidence-based spine care of value. Eur. Spine J. 30, 2091\u20132101 (2021).","journal-title":"Eur. Spine J."},{"key":"56527_CR8","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.1016\/S0140-6736(05)67604-0","volume":"366","author":"P Kannus","year":"2005","unstructured":"Kannus, P., Sievanen, H., Palvanen, M., Jarvinen, T. & Parkkari, J. Prevention of falls and consequent injuries in elderly people. Lancet 366, 1885\u20131893 (2005).","journal-title":"Lancet"},{"key":"56527_CR9","doi-asserted-by":"publisher","first-page":"2236","DOI":"10.1001\/jama.2015.6250","volume":"313","author":"NB Jain","year":"2015","unstructured":"Jain, N. B. et al. Traumatic spinal cord injury in the United States, 1993\u20132012. JAMA 313, 2236\u20132243 (2015).","journal-title":"JAMA"},{"key":"56527_CR10","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1089\/neu.2022.0009","volume":"39","author":"MG Fehlings","year":"2022","unstructured":"Fehlings, M. G., Pedro, K. & Hejrati, N. Management of acute spinal cord injury: Where have we been? Where are we now? Where are we going?. J. Neurotrauma 39, 1591\u20131602 (2022).","journal-title":"J. Neurotrauma"},{"key":"56527_CR11","unstructured":"Ministry_of_Health_Labour_and_Welfare. The Results of National Health and Nutrition Survey 2018 (written in Japanese). https:\/\/www.mhlw.go.jp\/stf\/newpage_14156.html. Accessed 9 March 2024 (2020)."},{"key":"56527_CR12","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1038\/ejcn.2013.238","volume":"68","author":"S Wong","year":"2014","unstructured":"Wong, S., Derry, F., Jamous, A., Hirani, S. P. & Forbes, A. Is undernutrition risk associated with an adverse clinical outcome in spinal cord-injured patients admitted to a spinal centre?. Eur. J. Clin. Nutr. 68, 125\u2013130 (2014).","journal-title":"Eur. J. Clin. Nutr."},{"key":"56527_CR13","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1179\/2045772313Y.0000000131","volume":"37","author":"X Chen","year":"2014","unstructured":"Chen, X., Liu, Z., Sun, T., Ren, J. & Wang, X. Relationship between nutritional status and mortality during the first 2 weeks following treatment for cervical spinal cord injury. J. Spinal Cord Med. 37, 72\u201378 (2014).","journal-title":"J. Spinal Cord Med."},{"key":"56527_CR14","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/s41393-019-0245-9","volume":"57","author":"M Tanaka","year":"2019","unstructured":"Tanaka, M., Momosaki, R., Wakabayashi, H., Kikura, T. & Maeda, K. Relationship between nutritional status and improved ADL in individuals with cervical spinal cord injury in a convalescent rehabilitation ward. Spinal Cord 57, 501\u2013508 (2019).","journal-title":"Spinal Cord"},{"key":"56527_CR15","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1093\/ajcn\/82.4.777","volume":"82","author":"O Bouillanne","year":"2005","unstructured":"Bouillanne, O. et al. Geriatric Nutritional Risk Index: A new index for evaluating at-risk elderly medical patients. Am. J. Clin. Nutr. 82, 777\u2013783 (2005).","journal-title":"Am. J. Clin. Nutr."},{"key":"56527_CR16","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1093\/ajcn\/87.1.106","volume":"87","author":"K Yamada","year":"2008","unstructured":"Yamada, K. et al. Simplified nutritional screening tools for patients on maintenance hemodialysis. Am. J. Clin. Nutr. 87, 106\u2013113 (2008).","journal-title":"Am. J. Clin. Nutr."},{"key":"56527_CR17","doi-asserted-by":"publisher","first-page":"3361","DOI":"10.1093\/ndt\/gfq211","volume":"25","author":"I Kobayashi","year":"2010","unstructured":"Kobayashi, I. et al. Geriatric Nutritional Risk Index, a simplified nutritional screening index, is a significant predictor of mortality in chronic dialysis patients. Nephrol. Dial. Transplant. 25, 3361\u20133365 (2010).","journal-title":"Nephrol. Dial. Transplant."},{"key":"56527_CR18","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1002\/jcsm.12800","volume":"12","author":"GT Ruan","year":"2021","unstructured":"Ruan, G. T. et al. Geriatric nutrition risk index: Prognostic factor related to inflammation in elderly patients with cancer cachexia. J. Cachexia Sarcopenia Muscle 12, 1969\u20131982 (2021).","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"56527_CR19","doi-asserted-by":"publisher","first-page":"8318","DOI":"10.1038\/s41598-022-12357-4","volume":"12","author":"Y Kawakubo","year":"2022","unstructured":"Kawakubo, Y. et al. Potential association with malnutrition and allocation of combination medical therapies in hospitalized heart failure patients with reduced ejection fraction. Sci. Rep. 12, 8318 (2022).","journal-title":"Sci. Rep."},{"key":"56527_CR20","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1089\/neu.2021.0351","volume":"39","author":"H Nakajima","year":"2022","unstructured":"Nakajima, H. et al. Prognostic factors for cervical spinal cord injury without major bone injury in elderly patients. J. Neurotrauma 39, 658\u2013666 (2022).","journal-title":"J. Neurotrauma"},{"key":"56527_CR21","doi-asserted-by":"publisher","first-page":"15867","DOI":"10.1038\/s41598-022-19789-y","volume":"12","author":"N Yokogawa","year":"2022","unstructured":"Yokogawa, N. et al. Differences in clinical characteristics of cervical spine injuries in older adults by external causes: A multicenter study of 1512 cases. Sci. Rep. 12, 15867 (2022).","journal-title":"Sci. Rep."},{"key":"56527_CR22","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1177\/21925682221095470","volume":"14","author":"R Hirota","year":"2022","unstructured":"Hirota, R. et al. Prognostic factors for respiratory dysfunction for cervical spinal cord injury and\/or cervical fractures in elderly patients: A multicenter survey. Glob. Spine J. 14, 101\u2013112 (2022).","journal-title":"Glob. Spine J."},{"key":"56527_CR23","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1179\/204577211X13207446293695","volume":"34","author":"SC Kirshblum","year":"2011","unstructured":"Kirshblum, S. C. et al. International standards for neurological classification of spinal cord injury (revised 2011). J. Spinal Cord Med. 34, 535\u2013546 (2011).","journal-title":"J. Spinal Cord Med."},{"key":"56527_CR24","doi-asserted-by":"publisher","first-page":"205","DOI":"10.2307\/2529686","volume":"29","author":"SJ Haberman","year":"1973","unstructured":"Haberman, S. J. The analysis of residuals in cross-classified tables. Biometrics 29, 205\u2013220 (1973).","journal-title":"Biometrics"},{"key":"56527_CR25","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s41393-018-0218-4","volume":"57","author":"GJ Farkas","year":"2019","unstructured":"Farkas, G. J., Pitot, M. A., Berg, A. S. & Gater, D. R. Nutritional status in chronic spinal cord injury: A systematic review and meta-analysis. Spinal Cord 57, 3\u201317 (2019).","journal-title":"Spinal Cord"},{"key":"56527_CR26","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1111\/jhn.12807","volume":"33","author":"L Payne","year":"2020","unstructured":"Payne, L. et al. Beliefs about inevitable decline among home-living older adults at risk of malnutrition: A qualitative study. J. Hum. Nutr. Diet. 33, 841\u2013851 (2020).","journal-title":"J. Hum. Nutr. Diet."},{"key":"56527_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2020.115700","volume":"142","author":"G Rodriguez","year":"2021","unstructured":"Rodriguez, G. et al. Musculoskeletal morbidity following spinal cord injury: A longitudinal cohort study of privately-insured beneficiaries. Bone 142, 115700 (2021).","journal-title":"Bone"},{"key":"56527_CR28","doi-asserted-by":"publisher","first-page":"197","DOI":"10.46292\/sci2603-197","volume":"26","author":"DR Gater","year":"2020","unstructured":"Gater, D. R., Bauman, C. & Cowan, R. A primary care provider\u2019s guide to diet and nutrition after spinal cord injury. Top. Spinal Cord Inj. Rehabil. 26, 197\u2013202 (2020).","journal-title":"Top. Spinal Cord Inj. Rehabil."},{"key":"56527_CR29","doi-asserted-by":"publisher","first-page":"3262","DOI":"10.1007\/s00586-022-07432-3","volume":"31","author":"B Darwono","year":"2022","unstructured":"Darwono, B. et al. SPINE20 recommendations 2022: Spine care-working together to recover stronger. Eur. Spine J. 31, 3262\u20133273 (2022).","journal-title":"Eur. Spine J."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-56527-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-56527-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-56527-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T08:49:22Z","timestamp":1710406162000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-56527-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,11]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["56527"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-56527-y","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,11]]},"assertion":[{"value":"13 February 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"5853"}}