{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:57:00Z","timestamp":1791881820815,"version":"4.3.4"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Marie Sk\u0142odowska-Curie Foundation","award":["MSCF-ITN-764632"],"award-info":[{"award-number":["MSCF-ITN-764632"]}]},{"name":"InoMed","award":["No CZ.02.1.01\/0.0\/0.0\/18_069\/0010046"],"award-info":[{"award-number":["No CZ.02.1.01\/0.0\/0.0\/18_069\/0010046"]}]},{"name":"European Horizon 2020 I-CARE4OLD","award":["No 965341, START \/ MED \/ 093 EN.02.2.69 \/ 0.0 \/ 0.0 \/ 19_073 \/ 0016935, SVV 260 551"],"award-info":[{"award-number":["No 965341, START \/ MED \/ 093 EN.02.2.69 \/ 0.0 \/ 0.0 \/ 19_073 \/ 0016935, SVV 260 551"]}]},{"name":"Cooperatio research program of the Faculty of Pharmacy, Charles University","award":["Research Unit: \u201cAgeing, Polypharmacotherapy and Changes in Therapeutic Value of Drugs in the Aged\u2019\u2019, KSKF-I."],"award-info":[{"award-number":["Research Unit: \u201cAgeing, Polypharmacotherapy and Changes in Therapeutic Value of Drugs in the Aged\u2019\u2019, KSKF-I."]}]},{"name":"NETPHARM project","award":["CZ.02.01.01\/00\/22_008\/0004607"],"award-info":[{"award-number":["CZ.02.01.01\/00\/22_008\/0004607"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pharmacist\u2019s geriatric assessment can provide valuable insights into potential deprescribing targets, while including important information on various health-related domains. Data collected from a geriatric assessment questionnaire, for 388 patients, from the Croatian cohort of the EuroAgeism H2020 ESR 7 international project, along with guideline-based deprescribing criteria, were used to analyse potentially inappropriate prescribing of four medication groups (benzodiazepines (BZN), proton pump inhibitors (PPI), opioids, and non-steroidal anti-inflammatory drugs (NSAID)), and to assess the deprescribing potential. Binary logistic regression was used to explore the effects of age, gender, number of medicines and diagnoses, self-reported health, frailty score, and healthcare utilization on the likelihood of needing deprescribing. More than half of participants (n\u2009=\u2009216, 55.2%) are candidates for deprescribing, with 31.1% of PPI, 74.8% of NSAID, 75% of opioid, and 96.1% of BZN users meeting at least one criterion. Most common criteria for deprescribing were inappropriately long use and safety concerns. Women (aOR\u2009=\u20092.58; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), those reporting poor self-reported health (aOR\u2009=\u20095.14; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and those exposed to polypharmacy (aOR\u2009=\u20091.29; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) had higher odds of needing to have medicines deprescribed. The high rate of deprescribing potential warrants prompt action to increase patient safety and decrease polypharmacy. Pharmacist\u2019s geriatric assessment and deprescribing-focused medication review could be used to lead a personalised approach.<\/jats:p>","DOI":"10.1038\/s41598-024-56780-1","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T19:02:33Z","timestamp":1710442953000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Deprescribing potential of commonly used medications among community-dwelling older adults: insights from a pharmacist\u2019s geriatric assessment"],"prefix":"10.1038","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4140-8657","authenticated-orcid":false,"given":"Iva","family":"Bu\u017ean\u010di\u0107","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1539-4482","authenticated-orcid":false,"given":"Margita","family":"Dr\u017eai\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0205-1576","authenticated-orcid":false,"given":"Ingrid","family":"Kummer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1578-9764","authenticated-orcid":false,"given":"Maja","family":"Ortner Had\u017eiabdi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jovana","family":"Brki\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5638-9690","authenticated-orcid":false,"given":"Daniela","family":"Fialov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,14]]},"reference":[{"key":"56780_CR1","unstructured":"World Health Organization. Decade of Healthy Ageing: Baseline Report. World Health Organization (2020)."},{"key":"56780_CR2","first-page":"173","volume":"37","author":"B Roux","year":"2020","unstructured":"Roux, B., Sirois, C., Simard, M., Gagnon, M. E. & Laroche, M. L. Potentially inappropriate medications in older adults: A population-based cohort study. Fam. Pract. 37, 173\u2013179 (2020).","journal-title":"Fam. Pract."},{"key":"56780_CR3","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.vhri.2021.05.003","volume":"25","author":"SK Malakouti","year":"2021","unstructured":"Malakouti, S. K. et al. A systematic review of potentially inappropriate medications use and related costs among the elderly. Value Heal. Reg. Issues 25, 172\u2013179 (2021).","journal-title":"Value Heal. Reg. Issues"},{"key":"56780_CR4","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1007\/s40471-021-00274-5","volume":"8","author":"HE Barry","year":"2021","unstructured":"Barry, H. E. & Hughes, C. M. An update on medication use in older adults: A narrative review. Curr. Epidemiol. Rep. 8, 108 (2021).","journal-title":"Curr. Epidemiol. Rep."},{"key":"56780_CR5","doi-asserted-by":"publisher","first-page":"2018","DOI":"10.1111\/jgs.16136","volume":"67","author":"A Linsky","year":"2019","unstructured":"Linsky, A., Gellad, W. F., Linder, J. A. & Friedberg, M. W. Advancing the science of deprescribing: A novel comprehensive conceptual framework. J. Am. Geriatr. Soc. 67, 2018\u20132022 (2019).","journal-title":"J. Am. Geriatr. Soc."},{"key":"56780_CR6","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1111\/bcp.14525","volume":"87","author":"D Gnjidic","year":"2021","unstructured":"Gnjidic, D. & Reeve, E. Deprescribing: What do we know, and where to next?. Br. J. Clin. Pharmacol. 87, 722\u2013724 (2021).","journal-title":"Br. J. Clin. Pharmacol."},{"key":"56780_CR7","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1111\/bcp.12386","volume":"78","author":"E Reeve","year":"2014","unstructured":"Reeve, E., Shakib, S., Hendrix, I., Roberts, M. S. & Wiese, M. D. Review of deprescribing processes and development of an evidence-based, patient-centred deprescribing process. Br. J. Clin. Pharmacol. 78, 738\u2013747 (2014).","journal-title":"Br. J. Clin. Pharmacol."},{"key":"56780_CR8","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-30192-7_8","author":"TS Dharmarajan","year":"2021","unstructured":"Dharmarajan, T. S. Comprehensive geriatric assessment. Geriatr. Gastroenterol. https:\/\/doi.org\/10.1007\/978-3-030-30192-7_8 (2021).","journal-title":"Geriatr. Gastroenterol."},{"key":"56780_CR9","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1007\/s40266-018-0554-2","volume":"35","author":"D Mangin","year":"2018","unstructured":"Mangin, D. et al. International Group for Reducing Inappropriate Medication Use & Polypharmacy (IGRIMUP): Position statement and 10 recommendations for action. Drugs Aging 35, 575 (2018).","journal-title":"Drugs Aging"},{"key":"56780_CR10","unstructured":"Ward, K. T. & Reuben, D. B. Comprehensive geriatric assessment\u2014UpToDate. https:\/\/www.uptodate.com\/contents\/comprehensive-geriatric-assessment (2022)."},{"key":"56780_CR11","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1002\/jppr.1765","volume":"51","author":"G Godbole","year":"2021","unstructured":"Godbole, G., Bolitho, R. & Pont, L. Key concepts in medication management in older persons for pharmacists practicing in non-geriatric specialties. J. Pharm. Pract. Res. 51, 427\u2013434 (2021).","journal-title":"J. Pharm. Pract. Res."},{"key":"56780_CR12","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1007\/s41999-021-00501-8","volume":"12","author":"E Delgado-Silveira","year":"2021","unstructured":"Delgado-Silveira, E. & Bermejo-Vicedo, T. The role of pharmacists in geriatric teams: The time is now. Eur. Geriatr. Med. 12, 1119\u20131121 (2021).","journal-title":"Eur. Geriatr. Med."},{"key":"56780_CR13","unstructured":"EuroAgeism\u2014Inappropriate Prescribing and Availability of Medication Management Services in Older Patients in Europe. https:\/\/euroageism.eu\/projects\/inappropriate-prescribing-and-availability-of-medication-management-services-in-older-patients-in-europe\/."},{"key":"56780_CR14","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1177\/0884533614537076","volume":"29","author":"RA DiMnrin-Ghnlili","year":"2014","unstructured":"DiMnrin-Ghnlili, R. A. Integrating nutrition in the comprehensive geriatric assessment. Nutr. Clin. Pract. 29, 420\u2013427 (2014).","journal-title":"Nutr. Clin. Pract."},{"key":"56780_CR15","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1002\/jcsm.12048","volume":"7","author":"TK Malmstrom","year":"2016","unstructured":"Malmstrom, T. K., Miller, D. K., Simonsick, E. M., Ferrucci, L. & Morley, J. E. SARC-F: A symptom score to predict persons with sarcopenia at risk for poor functional outcomes. J. Cachexia. Sarcopenia Muscle 7, 28 (2016).","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"key":"56780_CR16","doi-asserted-by":"publisher","first-page":"M546","DOI":"10.1093\/gerona\/54.11.M546","volume":"54","author":"JN Morris","year":"1999","unstructured":"Morris, J. N., Fries, B. E. & Morris, S. A. Scaling ADLs within the MDS. J. Gerontol. Ser. A 54, M546\u2013M553 (1999).","journal-title":"J. Gerontol. Ser. A"},{"key":"56780_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12877-020-01801-7","volume":"20","author":"S Church","year":"2020","unstructured":"Church, S., Rogers, E., Rockwood, K. & Theou, O. A scoping review of the clinical frailty scale. BMC Geriatr. 20, 1\u201318 (2020).","journal-title":"BMC Geriatr."},{"key":"56780_CR18","doi-asserted-by":"publisher","first-page":"M174","DOI":"10.1093\/geronj\/49.4.M174","volume":"49","author":"JN Morris","year":"1994","unstructured":"Morris, J. N. et al. MDS cognitive performance Scale\u00a9. J. Gerontol. 49, M174\u2013M182 (1994).","journal-title":"J. Gerontol."},{"key":"56780_CR19","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1093\/ageing\/29.2.165","volume":"29","author":"AB Burrows","year":"2000","unstructured":"Burrows, A. B., Morris, J. N., Simon, S. E., Hirdes, J. P. & Phillips, C. Development of a minimum data set-based depression rating scale for use in nursing homes. Age Ageing 29, 165\u2013172 (2000).","journal-title":"Age Ageing"},{"key":"56780_CR20","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/0304-3959(87)91074-8","volume":"30","author":"R Melzack","year":"1987","unstructured":"Melzack, R. The short-form McGill pain questionnaire. Pain 30, 191\u2013197 (1987).","journal-title":"Pain"},{"key":"56780_CR21","unstructured":"Croatian Bureau of Statistics. Population statistics. https:\/\/podaci.dzs.hr\/en\/statistics\/population\/ (2022)."},{"key":"56780_CR22","unstructured":"Primary Health Tasmania, A. Resources: Medication management\u2014deprescribing. https:\/\/www.primaryhealthtas.com.au\/resources\/deprescribing-resources\/ (2022)."},{"key":"56780_CR23","doi-asserted-by":"publisher","unstructured":"American Geriatrics Society Beers Criteria\u00ae Update Expert Panel. American Geriatrics Society 2023 updated AGS Beers Criteria\u00ae for potentially inappropriate medication use in older adults. J. Am. Geriatr. Soc. (2023) https:\/\/doi.org\/10.1111\/JGS.18372.","DOI":"10.1111\/JGS.18372"},{"key":"56780_CR24","first-page":"3","volume":"120","author":"N-K Mann","year":"2023","unstructured":"Mann, N.-K. et al. Potentially inadequate medications in the elderly: PRISCUS 2.0 first update of the PRISCUS list. Dtsch Arztebl Int 120, 3 (2023).","journal-title":"Dtsch Arztebl Int"},{"key":"56780_CR25","doi-asserted-by":"publisher","first-page":"2200","DOI":"10.1111\/ggi.13062","volume":"17","author":"A Rodr\u00edguez-P\u00e9rez","year":"2017","unstructured":"Rodr\u00edguez-P\u00e9rez, A. et al. Novel tool for deprescribing in chronic patients with multimorbidity: List of evidence-based deprescribing for chronic patients criteria. Geriatr. Gerontol. Int. 17, 2200\u20132207 (2017).","journal-title":"Geriatr. Gerontol. Int."},{"issue":"1","key":"56780_CR26","first-page":"1","volume":"2023","author":"D O\u2019Mahony","year":"2023","unstructured":"O\u2019Mahony, D. et al. STOPP\/START criteria for potentially inappropriate prescribing in older people: Version 3. Eur. Geriatr. Med. 2023(1), 1\u20138 (2023).","journal-title":"Eur. Geriatr. Med."},{"key":"56780_CR27","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1093\/ageing\/afx138","volume":"46","author":"AH Lavan","year":"2017","unstructured":"Lavan, A. H. et al. STOPPFrail (screening tool of older persons prescriptions in frail adults with limited life expectancy): Consensus validation. Age Ageing 46, 600\u2013607 (2017).","journal-title":"Age Ageing"},{"key":"56780_CR28","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1093\/ageing\/afaa249","volume":"50","author":"LJ Seppala","year":"2021","unstructured":"Seppala, L. J. et al. STOPPFall (screening tool of older persons prescriptions in older adults with high fall risk): A Delphi study by the EuGMS task and finish group on fall-risk-increasing drugs. Age Ageing 50, 1189\u20131199 (2021).","journal-title":"Age Ageing"},{"key":"56780_CR29","unstructured":"Primary Health Tasmania, A. A Guide to Benzodiazepines Recommended Deprescribing Strategy. (2019)."},{"key":"56780_CR30","unstructured":"Primary Health Tasmania, A. Opioids Recommended Deprescribing Strategy. (2019)."},{"key":"56780_CR31","unstructured":"Primary Health Tasmania, A. Non-Steroidal Anti-Inflamatory Drugs Recommended Deprescribing Strategy (NSAIDs). (2019)."},{"key":"56780_CR32","unstructured":"NSW Therapeutic Advisory Group, A. Deprescribing Guide for Benzodiazepines and Z-Drugs. (2018)."},{"key":"56780_CR33","unstructured":"NSW Therepautic Advisory Group, A. Deprescribing Guide for Regular Long-Term Opioid Analgesic Use in Older Adults. (2018)."},{"key":"56780_CR34","first-page":"354","volume":"63","author":"B Farrell","year":"2017","unstructured":"Farrell, B. et al. Clinical practice guidelines deprescribing proton pump inhibitors evidence-based clinical practice guideline. Can. Fam. Physician Le M\u00e9decin Fam. Can. 63, 354\u2013364 (2017).","journal-title":"Can. Fam. Physician Le M\u00e9decin Fam. Can."},{"key":"56780_CR35","unstructured":"American Geriatrics Society. AGS Clinical Practice Guidelines and Recommendations. https:\/\/geriatricscareonline.org\/ProductTypeStore\/guidelines-recommendations-position-statements-\/8\/."},{"key":"56780_CR36","unstructured":"British Geriatrics Society. Clinical guidelines. https:\/\/www.bgs.org.uk\/resources\/resource-series\/clinical-guidelines."},{"key":"56780_CR37","unstructured":"Agency for Medicinal Products and Medical Devices of Croatia, H. Medicinal products database for dug group N05B and N05C (benzodiazepine receptor agonists). Medicinal Products Database https:\/\/www.halmed.hr\/Lijekovi\/Baza-lijekova\/#rezultati."},{"key":"56780_CR38","unstructured":"Wolters Kluwer. Lexicomp Drug Interactions Module. https:\/\/www.wolterskluwer.com\/en\/solutions\/lexicomp\/lexicomp."},{"key":"56780_CR39","doi-asserted-by":"crossref","unstructured":"Shetty, V. et al. Evaluation of potential drug-drug interactions with medications prescribed to geriatric patients in a Tertiary Care Hospital. J. Aging Res. 2018, (2018).","DOI":"10.1155\/2018\/5728957"},{"key":"56780_CR40","doi-asserted-by":"publisher","first-page":"e35","DOI":"10.1136\/ejhpharm-2017-001251","volume":"25","author":"ST Cheong","year":"2018","unstructured":"Cheong, S. T., Ng, T. M. & Tan, K. T. Pharmacist-initiated deprescribing in hospitalised elderly: Prevalence and acceptance by physicians. Eur. J. Hosp. Pharm. 25, e35\u2013e39 (2018).","journal-title":"Eur. J. Hosp. Pharm."},{"key":"56780_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2022.104910","volume":"107","author":"HW Quek","year":"2023","unstructured":"Quek, H. W. et al. Deprescribing for older people living in residential aged care facilities: Pharmacist recommendations, doctor acceptance and implementation. Arch. Gerontol. Geriatr. 107, 104910 (2023).","journal-title":"Arch. Gerontol. Geriatr."},{"key":"56780_CR42","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1053\/j.gastro.2021.12.247","volume":"162","author":"LE Targownik","year":"2022","unstructured":"Targownik, L. E., Fisher, D. A. & Saini, S. D. AGA clinical practice update on de-prescribing of proton pump inhibitors: Expert review. Gastroenterology 162, 1334\u20131342 (2022).","journal-title":"Gastroenterology"},{"key":"56780_CR43","doi-asserted-by":"publisher","first-page":"5469","DOI":"10.3390\/ijms20215469","volume":"20","author":"H Helgadottir","year":"2019","unstructured":"Helgadottir, H. & Bjornsson, E. S. Problems associated with deprescribing of proton pump inhibitors. Int. J. Mol. Sci. 20, 5469 (2019).","journal-title":"Int. J. Mol. Sci."},{"key":"56780_CR44","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1177\/17151635221149712","volume":"156","author":"KG Dawson","year":"2023","unstructured":"Dawson, K. G., Mok, V., Wong, J. G. M. & Bhalla, A. Deprescribing initiative of NSAIDs (DIN): Pharmacist-ledinterventions for pain management in a federal correctionalsetting. Can. Pharm. J. CPJ 156, 85 (2023).","journal-title":"Can. Pharm. J. CPJ"},{"key":"56780_CR45","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1001\/jama.2018.16131","volume":"320","author":"P Martin","year":"2018","unstructured":"Martin, P., Tamblyn, R., Benedetti, A., Ahmed, S. & Tannenbaum, C. Effect of a pharmacist-led educational intervention on inappropriate medication prescriptions in older adults: The D-PRESCRIBE randomized clinical trial. JAMA 320, 1889\u20131898 (2018).","journal-title":"JAMA"},{"key":"56780_CR46","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1111\/imj.15023","volume":"50","author":"P Glare","year":"2020","unstructured":"Glare, P., Ashton-James, C., Han, E. & Nicholas, M. Deprescribing long-term opioid therapy in patients with chronic pain. Intern. Med. J. 50, 1185\u20131191 (2020).","journal-title":"Intern. Med. J."},{"key":"56780_CR47","doi-asserted-by":"publisher","DOI":"10.1111\/BCPT.13844","author":"AV Langford","year":"2023","unstructured":"Langford, A. V. et al. Patient-targeted interventions for opioid deprescribing: An overview of systematic reviews. Basic Clin. Pharmacol. Toxicol. https:\/\/doi.org\/10.1111\/BCPT.13844 (2023).","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"56780_CR48","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/add.15997","volume":"118","author":"A Soni","year":"2023","unstructured":"Soni, A., Thiyagarajan, A. & Reeve, J. Feasibility and effectiveness of deprescribing benzodiazepines and Z-drugs: Systematic review and meta-analysis. Addiction 118, 7\u201316 (2023).","journal-title":"Addiction"},{"key":"56780_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13012-022-01206-7","volume":"17","author":"P Evrard","year":"2022","unstructured":"Evrard, P., P\u00e9tein, C., Beuscart, J. B. & Spinewine, A. Barriers and enablers for deprescribing benzodiazepine receptor agonists in older adults: A systematic review of qualitative and quantitative studies using the theoretical domains framework. Implement. Sci. 17, 1\u201327 (2022).","journal-title":"Implement. Sci."},{"key":"56780_CR50","doi-asserted-by":"publisher","first-page":"e290","DOI":"10.1016\/S2666-7568(21)00054-4","volume":"2","author":"PA Rochon","year":"2021","unstructured":"Rochon, P. A. et al. Polypharmacy, inappropriate prescribing, and deprescribing in older people: Through a sex and gender lens. Lancet Heal. Longev. 2, e290\u2013e300 (2021).","journal-title":"Lancet Heal. Longev."},{"key":"56780_CR51","doi-asserted-by":"publisher","DOI":"10.1111\/BCPT.13857","author":"SE Vordenberg","year":"2023","unstructured":"Vordenberg, S. E. et al. Reasons why older adults in three countries agreed with a deprescribing recommendation in a hypothetical vignette. Basic Clin. Pharmacol. Toxicol. https:\/\/doi.org\/10.1111\/BCPT.13857 (2023).","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"56780_CR52","doi-asserted-by":"publisher","first-page":"4159","DOI":"10.3390\/ijerph20054159","volume":"20","author":"MH Barghouth","year":"2023","unstructured":"Barghouth, M. H. et al. Polypharmacy and the change of self-rated health in community-dwelling older adults. Int. J. Environ. Res. Public Health 20, 4159 (2023).","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"56780_CR53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12877-020-01516-9","volume":"20","author":"M Wuorela","year":"2020","unstructured":"Wuorela, M. et al. Self-rated health and objective health status as predictors of all-cause mortality among older people: A prospective study with a 5-, 10-, and 27-year follow-up. BMC Geriatr. 20, 1\u20137 (2020).","journal-title":"BMC Geriatr."},{"key":"56780_CR54","doi-asserted-by":"publisher","first-page":"3032","DOI":"10.1111\/bcp.14990","volume":"88","author":"C Lundby","year":"2022","unstructured":"Lundby, C. & Potteg\u00e5rd, A. Considerations regarding choice of primary outcome in clinical trials in deprescribing. Br. J. Clin. Pharmacol. 88, 3032\u20133034 (2022).","journal-title":"Br. J. Clin. Pharmacol."},{"key":"56780_CR55","doi-asserted-by":"publisher","first-page":"2487","DOI":"10.1111\/jgs.17894","volume":"70","author":"EA Bayliss","year":"2022","unstructured":"Bayliss, E. A. et al. Recommendations for outcome measurement for deprescribing intervention studies. J. Am. Geriatr. Soc. 70, 2487\u20132497 (2022).","journal-title":"J. Am. Geriatr. Soc."},{"key":"56780_CR56","doi-asserted-by":"publisher","DOI":"10.1111\/BCPT.13925","author":"AE Olesen","year":"2023","unstructured":"Olesen, A. E., V\u00e6ver, T. J., Simonsen, M., Simonsen, P. G. & H\u00f8j, K. Deprescribing in primary care without deterioration of health-related outcomes: A real-life, quality improvement project. Basic Clin. Pharmacol. Toxicol. https:\/\/doi.org\/10.1111\/BCPT.13925 (2023).","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"56780_CR57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12877-021-02208-8","volume":"21","author":"K Ibrahim","year":"2021","unstructured":"Ibrahim, K. et al. A systematic review of the evidence for deprescribing interventions among older people living with frailty. BMC Geriatr. 21, 1\u201316 (2021).","journal-title":"BMC Geriatr."},{"key":"56780_CR58","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1177\/2042098617736192","volume":"9","author":"D Garfinkel","year":"2018","unstructured":"Garfinkel, D. Poly-de-prescribing to treat polypharmacy: Efficacy and safety. Ther. Adv. Drug Saf. 9, 25\u201343 (2018).","journal-title":"Ther. Adv. Drug Saf."},{"key":"56780_CR59","doi-asserted-by":"publisher","DOI":"10.1111\/dme.14801","volume":"39","author":"M Seewoodharry","year":"2022","unstructured":"Seewoodharry, M., Khunti, K., Davies, M. J., Gillies, C. & Seidu, S. Attitudes of older adults and their carers towards de-prescribing: A systematic review. Diabet. Med. 39, e14801 (2022).","journal-title":"Diabet. Med."},{"key":"56780_CR60","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1093\/gerona\/glab222","volume":"77","author":"KR Weir","year":"2022","unstructured":"Weir, K. R., Ailabouni, N. J., Schneider, C. R., Hilmer, S. N. & Reeve, E. Consumer attitudes towards deprescribing: A systematic review and meta-analysis. J. Gerontol. Ser. A 77, 1020\u20131034 (2022).","journal-title":"J. Gerontol. Ser. A"},{"key":"56780_CR61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12877-018-0788-1","volume":"18","author":"J Komagamine","year":"2018","unstructured":"Komagamine, J., Sugawara, K. & Hagane, K. Characteristics of elderly patients with polypharmacy who refuse to participate in an in-hospital deprescribing intervention: A retrospective cross-sectional study. BMC Geriatr. 18, 1\u20136 (2018).","journal-title":"BMC Geriatr."},{"key":"56780_CR62","doi-asserted-by":"publisher","first-page":"afac244","DOI":"10.1093\/ageing\/afac244","volume":"51","author":"N Ouellet","year":"2022","unstructured":"Ouellet, N. et al. Prescribing and deprescribing in very old age: Perceptions of very old adults, caregivers and health professionals. Age Ageing 51, afac244 (2022).","journal-title":"Age Ageing"},{"key":"56780_CR63","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1186\/s12877-023-03878-2","volume":"23","author":"MA Mohammed","year":"2023","unstructured":"Mohammed, M. A., Harrison, J., Milosavljevic, A. & Chan, A. H. Y. Attitude towards deprescribing and its association with frailty and complexity of medication regimen: A survey of older inpatients in a district health board in New Zealand. BMC Geriatr. 23, 166 (2023).","journal-title":"BMC Geriatr."},{"key":"56780_CR64","unstructured":"Agency for Medicinal Products and Medical Devices of Croatia, H. Drug Consumption Reports\u2014Drug Consumption | Traffic | Traffic, production and inspection.: HALMED. Report on the consumption of medcines in the Republic of Croatia https:\/\/www.halmed.hr\/Promet-proizvodnja-i-inspekcija\/Promet\/Potrosnja-lijekova\/Izvjesca-o-prometu-lijekova\/."},{"key":"56780_CR65","doi-asserted-by":"publisher","DOI":"10.1111\/BCPT.13899","author":"I Bu\u017ean\u010di\u0107","year":"2023","unstructured":"Bu\u017ean\u010di\u0107, I. & Ortner Had\u017eiabdi\u0107, M. Deprescribing in a multimorbid older adult: A case vignette study among community pharmacists and primary care physicians. Basic Clin. Pharmacol. Toxicol. https:\/\/doi.org\/10.1111\/BCPT.13899 (2023).","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"56780_CR66","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s40801-016-0098-x","volume":"4","author":"F Rhalimi","year":"2017","unstructured":"Rhalimi, F., Rhalimi, M. & Rauss, A. Pharmacist\u2019s comprehensive geriatric assessment: Introduction and evaluation at elderly patient admission. Drugs Real World Outcomes 4, 43 (2017).","journal-title":"Drugs Real World Outcomes"},{"key":"56780_CR67","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1001\/jamainternmed.2019.5096","volume":"180","author":"R Romskaug","year":"2020","unstructured":"Romskaug, R. et al. Effect of clinical geriatric assessments and collaborative medication reviews by geriatrician and family physician for improving health-related quality of life in home-dwelling older patients receiving polypharmacy: A cluster randomized clinical trial. JAMA Intern. Med. 180, 181 (2020).","journal-title":"JAMA Intern. Med."},{"key":"56780_CR68","doi-asserted-by":"publisher","first-page":"16774","DOI":"10.1038\/s41598-022-19860-8","volume":"12","author":"J Brkic","year":"2022","unstructured":"Brkic, J. et al. Prevalence of potentially inappropriate prescribing in older adults in Central and Eastern Europe: A systematic review and synthesis without meta-analysis. Sci. Rep. 12, 16774 (2022).","journal-title":"Sci. Rep."},{"key":"56780_CR69","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1093\/ageing\/afaa219","volume":"50","author":"R O\u2019Caoimh","year":"2021","unstructured":"O\u2019Caoimh, R. et al. Prevalence of frailty in 62 countries across the world: A systematic review and meta-analysis of population-level studies. Age Ageing 50, 96\u2013104 (2021).","journal-title":"Age Ageing"},{"key":"56780_CR70","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.sapharm.2020.04.029","volume":"17","author":"BE Bredhold","year":"2021","unstructured":"Bredhold, B. E. et al. Deprescribing opportunities for elderly inpatients in an academic, safety-net health system. Res. Soc. Adm. Pharm. 17, 541\u2013544 (2021).","journal-title":"Res. Soc. Adm. Pharm."}],"updated-by":[{"DOI":"10.1038\/s41598-024-60073-y","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000}}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-56780-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-56780-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-56780-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T16:09:24Z","timestamp":1713802164000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-56780-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,14]]},"references-count":70,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["56780"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-56780-1","relation":{"correction":[{"id-type":"doi","id":"10.1038\/s41598-024-60073-y","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,14]]},"assertion":[{"value":"18 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2024","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41598-024-60073-y","URL":"https:\/\/doi.org\/10.1038\/s41598-024-60073-y","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"6235"}}