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We characterized the predictors of health-related quality of life (HRQoL) in a sample of neurodiverse children and youth. We used a cross-sectional subsample from the Province of Ontario Neurodevelopmental Disorders Network (POND) consisting of those children and young people in the POND dataset with complete study data (total n\u2009=\u2009615; 31% female; age: 11.28\u00a0years\u2009\u00b1\u20092.84\u00a0years). Using a structural equation model, we investigated the effects of demographics (age, sex, socioeconomic status), core features (Social Communication Questionnaire, Toronto Obsessive Compulsive Scale, Strengths and Weaknesses of attention deficit\/hyperactivity disorder (ADHD)-symptoms and Normal Behavior), co-occurring symptoms (Child Behaviour Checklist), and adaptive functioning (Adaptive Behaviour Assessment System) on HRQoL (KINDL). A total of 615 participants had complete data for this study (autism\u2009=\u2009135, ADHD\u2009=\u2009273, subthreshold ADHD\u2009=\u20097, obsessive\u2013compulsive disorder (OCD)\u2009=\u200938, sub-threshold OCD\u2009=\u20091, neurotypical\u2009=\u2009161). Of these participants, 190 (31%) identified as female, and 425 (69%) identified as male. The mean age was 11.28\u00a0years\u2009\u00b1\u20092.84\u00a0years. Health-related quality of life was negatively associated with co-occurring symptoms (B\u2009=\u2009\u2212\u00a00.6, SE\u2009=\u20090.20, CI (\u2212\u00a00.95, \u2212\u00a00.19), p\u2009=\u20090.004)) and age (B\u2009=\u2009\u2212\u00a00.1, SE\u2009=\u20090.04, CI (\u2212\u00a00.19, \u2212\u00a00.01), p\u2009=\u20090.037). Fewer co-occurring symptoms were associated with higher socioeconomic status (B\u2009=\u2009\u2212\u00a00.5, SE\u2009=\u2009\u2212\u00a00.05, CI (\u2212\u00a00.58, \u2212\u00a00.37), p\u2009&lt;\u20090.001). This study used a cross-sectional design. Given that one\u2019s experiences, needs, supports, and environment and thus HrQoL may change significantly over the lifespan and a longitudinal analysis of predictors is needed to capture these changes. Future studies with more diverse participant groups are needed. These results demonstrate the importance of behavioural and sociodemographic characteristics on health-related quality of life across neurodevelopmental conditions.<\/jats:p>","DOI":"10.1038\/s41598-024-56821-9","type":"journal-article","created":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T10:01:54Z","timestamp":1710583314000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Predictors of health-related quality of life for children with neurodevelopmental conditions"],"prefix":"10.1038","volume":"14","author":[{"given":"Maryam","family":"Mahjoob","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn","family":"Cardy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Penner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evdokia","family":"Anagnostou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan F.","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Crosbie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Kelley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Ayub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Ayub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Brian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alana","family":"Iaboni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell","family":"Schachar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stelios","family":"Georgiades","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"Nicolson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azadeh","family":"Kushki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,16]]},"reference":[{"key":"56821_CR1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1089\/aut.2020.0014","volume":"3","author":"K Bottema-Beutel","year":"2021","unstructured":"Bottema-Beutel, K., Kapp, S. 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All co-authors meet the requirements for authorship and have reviewed and approved this manuscript. Dr Kushki is the inventor of a software called the \"Anxiety Meter\". She is involved in commercialising the Anxiety Meter (patents US 9,844,332 B2 and US 16\/276,208 (pending)) and will financially benefit from its sales. Dr Kushki served on the board of advisors for Shaftesbury, a media company developing virtual reality products for autistic children, from February 2020 to February 2021, and was compensated financially for this role. Dr Kushki has received donations of hardware for her research program from Samsung Canada. Dr Anagnostou reports grants from Roche, grants from Anavex, personal fees from Roche, personal fees from Quadrant, personal fees from Impel, personal fees from Ono, personal fees from Wiley, book royalties from Springer, book royalties from APPI, and non-financial support from AMO Pharma outside the submitted work. In addition, Dr Anagnostou holds a patent on the software called the \"Anxiety Meter\"; the Anxiety Meter is being commercialised and she will financially benefit from its sales. The other authors report no potential conflicts of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"6377"}}