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Lower LPLs level in the ventricular myocardium was also observed in aconitine-simulated ventricular fibrillation (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001) and ouabain-simulated III<jats:sup>\u00b0<\/jats:sup> atrioventricular block (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Shot-lasting electric shock, e.g.,\u2009\u2264\u200940\u00a0s, decreased LPLs level, while long-lasting, e.g., 5\u00a0min, increased it (fold change\u2009=\u20092.27, <jats:italic>P<\/jats:italic>\u2009=\u20090.0008). LPLs accumulation was observed in long-lasting myocardial ischemia, e.g., 4\u00a0h (fold change\u2009=\u20091.20, <jats:italic>P<\/jats:italic>\u2009=\u20090.0012), when caspase3 activity was elevated (<jats:italic>P<\/jats:italic>\u2009=\u20090.0012), indicating increased cell death, but not coincided with higher frequent arrhythmias. In postmortem human ventricular myocardium, differences of LPLs level in left ventricular myocardium was not observed among coronary artery disease- and other heart diseases-caused sudden death and non-heart disease caused death. LPLs level manifested a remarkable increasing from postmortem 12\u00a0h on in rats, thus abolishing the potential for serving as biomarkers of sudden cardiac death. Token together, in this study we found that LPLs in ventricular myocardium were initially decreased by the onset of ischemia, LPLs accumulation do not confer arrhythmogenesis during acute myocardial ischemia. It is necessary to reassess the roles of LPLs in myocardial infarction.<\/jats:p>","DOI":"10.1038\/s41598-024-57047-5","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T10:03:04Z","timestamp":1714125784000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Arrhythmia onsets triggered by acute myocardial ischemia are not mediated by lysophosphoglycerides accumulation in ventricular myocardium"],"prefix":"10.1038","volume":"14","author":[{"given":"Jiawei","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Mai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yafei","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoli","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinbiao","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangeng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuquan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoshan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuiping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erwen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,4,26]]},"reference":[{"key":"57047_CR1","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1161\/CIRCEP.113.001034","volume":"7","author":"EC Stecker","year":"2014","unstructured":"Stecker, E. 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