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With vitamin D insufficiency frequently co-occurring with FLD and linked to metabolic abnormalities, this study investigates the potential role of vitamin D in the development of MAFLD. In this cross-sectional analysis, 22,476 participants with baseline metabolic dysfunction and known serum 25-OH-vitamin D3 levels were examined. The fatty liver index (FLI) was utilized to predict FLD, dividing subjects into MAFLD and non-MAFLD groups. Further stratification by vitamin D levels (sufficient vs. insufficient) and gender provided a detailed assessment through binary logistic regression to determine the association of vitamin D status with MAFLD incidence. Vitamin D insufficiency correlated with a higher MAFLD incidence in metabolically impaired individuals. Post-adjustment, the correlation was stronger (men: aOR\u2009=\u20091.32, 95% CI\u2009=\u20091.22\u20131.43, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001; women: aOR\u2009=\u20091.53, 95% CI\u2009=\u20091.18\u20131.98, <jats:italic>P<\/jats:italic>\u2009=\u20090.001). Lower serum 25-OH-vitamin D3 levels were found in MAFLD patients across genders (men: <jats:italic>P<\/jats:italic>\u2009=\u20090.003; women: <jats:italic>P<\/jats:italic>\u2009=\u20090.014), with a higher prevalence of insufficiency in MAFLD cases (men: <jats:italic>P<\/jats:italic>\u2009=\u20090.007; women: <jats:italic>P<\/jats:italic>\u2009=\u20090.003). The vitamin D-MAFLD link was stable across subgroups and using varying FLI criteria. Our findings indicate a clear association between vitamin D insufficiency and increased MAFLD incidence, underscoring the potential of vitamin D as an anti-lipogenic and anti-fibrotic agent.<\/jats:p>","DOI":"10.1038\/s41598-024-57380-9","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T16:02:26Z","timestamp":1710950546000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The contribution of vitamin D insufficiency to the onset of steatotic liver disease among individuals with metabolic dysfunction"],"prefix":"10.1038","volume":"14","author":[{"given":"Su-bin","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Hyeon","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong-Hyun","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,20]]},"reference":[{"key":"57380_CR1","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/hep.28431","volume":"64","author":"ZM Younossi","year":"2016","unstructured":"Younossi, Z. 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