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This study aimed to investigate the relationship between <jats:italic>NF2<\/jats:italic>-SWN disease severity, health-related Quality of Life (QoL), and mental health aspects of patients. Standardised questionnaires assessing mental health problems (symptoms of depression, anxiety, and somatic burden), psychological factors (resilience, loneliness, and personality functioning), and health-related QoL were administered to 97 patients with <jats:italic>NF2<\/jats:italic>-SWN. The results of these questionnaires were compared with physician-rated disease severity. Questionnaires were completed by 77 patients. Physician-rated disease severity scores were available for 55 patients. <jats:italic>NF2<\/jats:italic>-SWN patients showed a high prevalence of clinically relevant symptoms of depression (30%), anxiety (16%), and somatic burden (32%). Almost all variables showed moderate to high correlations with <jats:italic>NF2<\/jats:italic>-SWN-related QoL. <jats:italic>NF2<\/jats:italic>-SWN-related QoL was associated with physician-reported disease severity (<jats:italic>r<\/jats:italic>\u2009=\u20090.614). In the stepwise hierarchical linear regression analysis, a significant model with four predictors (disease severity type, depression symptoms, personality functioning, and gender) explained 64% of the variance in <jats:italic>NF2<\/jats:italic>-SWN-related QoL. Our results showed a strong association between <jats:italic>NF2<\/jats:italic>-SWN-related QoL and depression symptoms. Moreover, personality functioning is an important influencing factor, representing a modifiable construct that can be targeted by prevention programs or psychotherapy.<\/jats:p>","DOI":"10.1038\/s41598-024-57401-7","type":"journal-article","created":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T07:09:31Z","timestamp":1711177771000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The impact of mental health on health-related quality of life in patients with NF2-related Schwannomatosis"],"prefix":"10.1038","volume":"14","author":[{"given":"Anna","family":"Freier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna C.","family":"Lawson McLean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Loeschner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen K.","family":"Rosahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Kruse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,23]]},"reference":[{"key":"57401_CR1","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1186\/s13023-022-02343-4","volume":"17","author":"K Bogart","year":"2022","unstructured":"Bogart, K. et al. 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