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However, the prevalence and detailed clinical features of <jats:italic>MYO7A<\/jats:italic>-associated hearing loss across a large population remain unclear. In this study, we conducted next-generation sequencing analysis for a large cohort of 10,042 Japanese hearing loss patients. As a result, 137 patients were identified with <jats:italic>MYO7A<\/jats:italic>-associated hearing loss so that the prevalence among Japanese hearing loss patients was 1.36%. We identified 70 disease-causing candidate variants in this study, with 36 of them being novel variants. All variants identified in autosomal dominant cases were missense or in-frame deletion variants. Among the autosomal recessive cases, all patients had at least one missense variant. On the other hand, in patients with Usher syndrome, almost half of the patients carried biallelic null variants (nonsense, splicing, and frameshift variants). Most of the autosomal dominant cases showed late-onset progressive hearing loss. On the other hand, cases with autosomal recessive inheritance or Usher syndrome showed congenital or early-onset hearing loss. The visual symptoms in the Usher syndrome cases developed between age 5\u201315, and\u00a0the condition was diagnosed at\u00a0about 6\u201315\u00a0years of age.<\/jats:p>","DOI":"10.1038\/s41598-024-57415-1","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T16:03:04Z","timestamp":1712678584000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The prevalence and clinical features of MYO7A-related hearing loss including DFNA11, DFNB2 and 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