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Our meta-analysis, which included studies up to April 2023 from PubMed\/MEDLINE, Embase, and Cochrane Library, aimed to clarify the impact of ILA on mortality, lung cancer development, and complications from lung cancer treatments. Risk ratios (RR) with 95% confidence intervals (CI) were calculated for outcomes. Analyzing 10 studies on ILA prognosis and 9 on cancer treatment complications, we found that ILA significantly increases the risk of overall mortality (RR 2.62, 95% CI 1.94\u20133.54; I\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u200990%) and lung cancer development (RR 3.85, 95% CI 2.64\u20135.62; I\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u200922%). Additionally, cancer patients with ILA had higher risks of grade 2 radiation pneumonitis (RR 2.28, 95% CI 1.71\u20133.03; I\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090%) and immune checkpoint inhibitor-related interstitial lung disease (RR 3.05, 95% CI 1.37\u20136.77; I\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u200983%) compared with those without ILA. In conclusion, ILA significantly associates with increased mortality, lung cancer risk, and cancer treatment-related complications, highlighting the necessity for vigilant patient management and monitoring.\n                  <\/jats:p>","DOI":"10.1038\/s41598-024-57831-3","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T14:05:09Z","timestamp":1711548309000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Clinical outcomes of interstitial lung abnormalities: a systematic review and meta-analysis"],"prefix":"10.1038","volume":"14","author":[{"given":"Jinwoo","family":"Seok","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinhee","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Chong","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee-Young","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,27]]},"reference":[{"key":"57831_CR1","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1183\/09059180.00009113","volume":"23","author":"KM Antoniou","year":"2014","unstructured":"Antoniou, K. 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