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It has been suggested that changes in the NO pathway and\u00a0heightened oxidative stress\u00a0may play a role in developing this condition. Anethole is a diterpene aromatic compound found in the Umbelliferae, Apiaceae, and Schisandraceae families. It has potential pharmacological effects like antioxidant, anxiolytic, analgesic, anti-inflammatory, antidiabetic, gastroprotective, anticancer, estrogenic, and antimicrobial activities. This study aimed to investigate the potential antidepressant properties of Anethole in a\u00a0mouse model\u00a0experiencing\u00a0maternal separation stress while also examining its impact on\u00a0oxidative stress\u00a0and\u00a0nitrite levels. The research involved the participation of 40 male\u00a0NMRI mice, separated into five distinct groups to conduct the study. The control group was administered 1 ml\/kg of normal saline, while the\u00a0MS groups\u00a0were given normal saline and Anethole at 10, 50, and 100 mg\/kg doses.\u00a0The study comprised various\u00a0behavioural tests, including the\u00a0open field test\u00a0(OFT), forced swimming test (FST), and\u00a0splash test, to assess the effects of Anethole on the mice. In addition to the behavioural tests, measurements were taken to evaluate the\u00a0total antioxidant capacity\u00a0(TAC), malondialdehyde (MDA), and\u00a0nitrite levels\u00a0in the hippocampus of the mice. According to the findings,\u00a0maternal separation\u00a0stress (MS) led to depressive-like conduct in mice, including a rise in immobility duration during the FST and a reduction in the duration of\u00a0grooming behaviour\u00a0in the\u00a0splash test. Additionally, the results indicated that MS correlated with an increase in the levels of MDA and nitrite and a reduction in the TAC in the hippocampus. However, the administration of Anethole resulted in an increase in grooming activity time during the\u00a0splash test\u00a0and a decrease in\u00a0immobility time\u00a0during the FST. Anethole also exhibited\u00a0antioxidant characteristics, as demonstrated by its ability to lower MDA and\u00a0nitrite levels\u00a0while increasing the TAC in the hippocampus. The results suggest that Anethole may have an antidepressant-like impact on mice separated from their mothers, likely partly due to its\u00a0antioxidant properties\u00a0in the hippocampus.<\/jats:p>","DOI":"10.1038\/s41598-024-57959-2","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T13:02:23Z","timestamp":1712062943000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Anethole as a promising antidepressant for maternal separation stress in mice by modulating oxidative stress and nitrite imbalance"],"prefix":"10.1038","volume":"14","author":[{"given":"Najmeh","family":"Rostami-Faradonbeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Amini-Khoei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Zarean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Bijad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Lorigooini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,2]]},"reference":[{"issue":"1","key":"57959_CR1","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.jaac.2013.09.017","volume":"53","author":"WE Copeland","year":"2014","unstructured":"Copeland, W. 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