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The study investigated the susceptible alleles of both Class I and II molecules of the\n                    <jats:italic>HLA<\/jats:italic>\n                    gene in 56 Thai BD patients and 192 healthy controls through next-generation sequencing using a PacBio kit. The study assessed 56 BD patients, primarily females (58.9%), revealing diverse manifestations including ocular (41.1%), vascular (35.7%), skin (55.4%), CNS (5.4%), and GI system (10.7%) involvement. This study found associations between BD and\n                    <jats:italic>HLA-A*26:01:01<\/jats:italic>\n                    (OR 3.285, 95% CI 1.135\u20139.504,\n                    <jats:italic>P<\/jats:italic>\n                    -value 0.028),\n                    <jats:italic>HLA-B*39:01:01<\/jats:italic>\n                    (OR 6.176, 95% CI 1.428\u201326.712,\n                    <jats:italic>P<\/jats:italic>\n                    -value 0.015),\n                    <jats:italic>HLA-B*51:01:01<\/jats:italic>\n                    (OR 3.033, 95% CI 1.135\u20138.103,\n                    <jats:italic>P<\/jats:italic>\n                    -value 0.027),\n                    <jats:italic>HLA-B*51:01:02<\/jats:italic>\n                    (OR 6.176, 95% CI 1.428\u201326.712,\n                    <jats:italic>P<\/jats:italic>\n                    -value 0.015),\n                    <jats:italic>HLA-C*14:02:01<\/jats:italic>\n                    (OR 3.485, 95% CI 1.339\u20139.065,\n                    <jats:italic>P<\/jats:italic>\n                    -value 0.01),\n                    <jats:italic>HLA-DRB1*14:54:01<\/jats:italic>\n                    (OR 1.924, 95% CI 1.051\u20133.522,\n                    <jats:italic>P<\/jats:italic>\n                    -value 0.034), and\n                    <jats:italic>HLA-DQB1*05:03:01<\/jats:italic>\n                    (OR 3.00, 95% CI 1.323\u20136.798,\n                    <jats:italic>P<\/jats:italic>\n                    -value 0.008). However, after Bonferroni correction none of these alleles were found to be associated with BD. In haplotype analysis, we found a strong linkage disequilibrium in\n                    <jats:italic>HLA-B*51:01:01<\/jats:italic>\n                    ,\n                    <jats:italic>HLA-C*14:02:01<\/jats:italic>\n                    (\n                    <jats:italic>P<\/jats:italic>\n                    -value 0.0, Pc-value 0.02). Regarding the phenotype, a significant association was found between\n                    <jats:italic>HLA-DRB1*14:54:01<\/jats:italic>\n                    (OR 11.67, 95% CI 2.86\u201347.57,\n                    <jats:italic>P<\/jats:italic>\n                    -value 0.001) and BD with ocular involvement, apart from this, no distinct phenotype-\n                    <jats:italic>HLA<\/jats:italic>\n                    association was documented. In summary, our study identifies specific\n                    <jats:italic>HLA<\/jats:italic>\n                    associations in BD. Although limited by a small sample size, we acknowledge the need for further investigation into\n                    <jats:italic>HLA<\/jats:italic>\n                    relationships with CNS, GI, and neurological phenotypes in the Thai population.\n                  <\/jats:p>","DOI":"10.1038\/s41598-024-58254-w","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T14:02:01Z","timestamp":1712239321000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Novel genetic variants of HLA gene associated with Thai Behcet\u2019s disease (BD) patients using next generation sequencing technology"],"prefix":"10.1038","volume":"14","author":[{"given":"Gaidganok","family":"Sornsamdang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Shobana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumutnart","family":"Chanprapaph","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wasun","family":"Chantratita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sasithorn","family":"Chotewutmontri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preeyachat","family":"Limtong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pichaya","family":"O-charoen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chonlaphat","family":"Sukasem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,4,4]]},"reference":[{"issue":"4 Suppl 60","key":"58254_CR1","first-page":"S2","volume":"28","author":"H Beh\u00e7et","year":"2010","unstructured":"Beh\u00e7et, H. & Matteson, E. 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