{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:03:55Z","timestamp":1791669835385,"version":"4.3.4"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100007653","name":"Universit\u00e4tsklinikum Jena","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007653","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prognostic factors for overall survival (OS), percutaneous endoscopic gastrostomy (PEG) dependency, and long-term speech rehabilitation via voice prosthesis (VP) after laryngectomy for laryngeal or hypopharyngeal cancer were investigated in a retrospective population-based study in Thuringia, Germany. A total of 617 patients (68.7% larynx; hypopharynx; 31.3%; 93.7% men; median age 62\u00a0years; 66.0% stage IV) from 2001 to 2020 were included. Kaplan\u2013Meier and Cox multivariable regression analyses were performed. 23.7% of patients received a PEG. 74.7% received a VP. Median OS was 131\u00a0months. Independent factors for lower OS were stage IV (compared to stage II; hazard ratio [HR]\u2009=\u20093.455; confidence interval [CI] 1.395\u20138.556) and laryngectomy for a recurrent disease (HR\u2009=\u20091.550; CI 1.078\u20132.228). Median time to PEG removal was 7\u00a0months. Prior partial surgery before laryngectomy showed a tendency for independent association for later PEG removal (HR\u2009=\u20091.959; CI 0.921\u20134.167). Postoperative aspiration needing treatment was an independent risk factor (HR\u2009=\u20092.679; CI 1.001\u20137.167) for later definitive VP removal. Laryngectomy continuously plays an important role in a curative daily routine treatment setting of advanced laryngeal or hypopharyngeal cancer in Germany. Long-term dependency on nutrition via PEG is an important issue, whereas use of VP is a stable long-term measure for voice rehabilitation.<\/jats:p>","DOI":"10.1038\/s41598-024-58423-x","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T13:02:23Z","timestamp":1712062943000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Oncological and functional outcome after laryngectomy for laryngeal and hypopharyngeal cancer: a population-based analysis in Germany from 2001 to 2020"],"prefix":"10.1038","volume":"14","author":[{"given":"Mussab","family":"Kouka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Beckmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Bitter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Kaftan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"B\u00f6ger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"B\u00fcntzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiri","family":"Podzimek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Pietschmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Ernst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9671-0784","authenticated-orcid":false,"given":"Orlando","family":"Guntinas-Lichius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,2]]},"reference":[{"key":"58423_CR1","doi-asserted-by":"publisher","first-page":"31","DOI":"10.3322\/caac.21386","volume":"67","author":"CE Steuer","year":"2017","unstructured":"Steuer, C. E., El-Deiry, M., Parks, J. R., Higgins, K. A. & Saba, N. F. An update on larynx cancer. CA Cancer J. Clin. 67, 31\u201350. https:\/\/doi.org\/10.3322\/caac.21386 (2017).","journal-title":"CA Cancer J. Clin."},{"key":"58423_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13061405","author":"TK Hoffmann","year":"2021","unstructured":"Hoffmann, T. K. Total laryngectomy-still cutting-edge?. Cancers. https:\/\/doi.org\/10.3390\/cancers13061405 (2021).","journal-title":"Cancers."},{"key":"58423_CR3","doi-asserted-by":"publisher","first-page":"419","DOI":"10.3389\/fonc.2019.00419","volume":"9","author":"A Argiris","year":"2019","unstructured":"Argiris, A. & Lefebvre, J. L. Laryngeal preservation strategies in locally advanced laryngeal and hypopharyngeal cancers. Front. Oncol. 9, 419. https:\/\/doi.org\/10.3389\/fonc.2019.00419 (2019).","journal-title":"Front. Oncol."},{"key":"58423_CR4","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1002\/hed.27545","volume":"46","author":"LE Cortina","year":"2024","unstructured":"Cortina, L. E. et al. Predictors of multiple dilations and functional outcomes after total laryngectomy and laryngopharyngectomy. Head Neck 46, 138\u2013144. https:\/\/doi.org\/10.1002\/hed.27545 (2024).","journal-title":"Head Neck"},{"key":"58423_CR5","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/j.ijrobp.2012.03.005","volume":"84","author":"M Machtay","year":"2012","unstructured":"Machtay, M. et al. Hypopharyngeal dose is associated with severe late toxicity in locally advanced head-and-neck cancer: An RTOG analysis. Int. J. Radiat. Oncol. Biol. Phys. 84, 983\u2013989. https:\/\/doi.org\/10.1016\/j.ijrobp.2012.03.005 (2012).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"58423_CR6","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s41199-020-00059-1","volume":"5","author":"A Cmelak","year":"2020","unstructured":"Cmelak, A. et al. ECOG-ACRIN 2399: Analysis of patient related outcomes after Chemoradiation for locally advanced head and neck Cancer. Cancers Head Neck 5, 12. https:\/\/doi.org\/10.1186\/s41199-020-00059-1 (2020).","journal-title":"Cancers Head Neck"},{"key":"58423_CR7","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1200\/JCO.2012.43.6097","volume":"31","author":"AA Forastiere","year":"2013","unstructured":"Forastiere, A. A. et al. Long-term results of RTOG 91\u201311: A comparison of three nonsurgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer. J. Clin. Oncol. 31, 845\u2013852. https:\/\/doi.org\/10.1200\/JCO.2012.43.6097 (2013).","journal-title":"J. Clin. Oncol."},{"key":"58423_CR8","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.ejca.2021.05.021","volume":"153","author":"CM Nutting","year":"2021","unstructured":"Nutting, C. M. et al. Dose-escalated intensity-modulated radiotherapy in patients with locally advanced laryngeal and hypopharyngeal cancers: ART DECO, a phase III randomised controlled trial. Eur. J. Cancer 153, 242\u2013256. https:\/\/doi.org\/10.1016\/j.ejca.2021.05.021 (2021).","journal-title":"Eur. J. Cancer"},{"key":"58423_CR9","doi-asserted-by":"publisher","DOI":"10.1002\/lary.31129","author":"O Laccourreye","year":"2023","unstructured":"Laccourreye, O. et al. Primary total laryngectomy for endolaryngeal cT3-4M0 squamous cell carcinoma: A STROBE analysis. Laryngoscope. https:\/\/doi.org\/10.1002\/lary.31129 (2023).","journal-title":"Laryngoscope."},{"key":"58423_CR10","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/bjc.2013.725","volume":"110","author":"CM Booth","year":"2014","unstructured":"Booth, C. M. & Tannock, I. F. Randomised controlled trials and population-based observational research: Partners in the evolution of medical evidence. Br. J. Cancer 110, 551\u2013555. https:\/\/doi.org\/10.1038\/bjc.2013.725 (2014).","journal-title":"Br. J. Cancer"},{"key":"58423_CR11","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1186\/s12885-022-09533-0","volume":"22","author":"LN Ruiter","year":"2022","unstructured":"Ruiter, L. N. et al. Association of histological features with laryngeal squamous cell carcinoma recurrences: A population-based study of 1502 patients in the Netherlands. BMC Cancer 22, 444. https:\/\/doi.org\/10.1186\/s12885-022-09533-0 (2022).","journal-title":"BMC Cancer"},{"key":"58423_CR12","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s00405-017-4766-6","volume":"275","author":"JF Petersen","year":"2018","unstructured":"Petersen, J. F. et al. Trends in treatment, incidence and survival of hypopharynx cancer: A 20-year population-based study in the Netherlands. Eur. Arch. Oto-rhino-laryngol. 275, 181\u2013189. https:\/\/doi.org\/10.1007\/s00405-017-4766-6 (2018).","journal-title":"Eur. Arch. Oto-rhino-laryngol."},{"key":"58423_CR13","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1080\/0284186X.2018.1438657","volume":"57","author":"KK Jakobsen","year":"2018","unstructured":"Jakobsen, K. K. et al. Increasing incidence and survival of head and neck cancers in Denmark: A nation-wide study from 1980 to 2014. Acta Oncol. 57, 1143\u20131151. https:\/\/doi.org\/10.1080\/0284186X.2018.1438657 (2018).","journal-title":"Acta Oncol."},{"key":"58423_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12113418","author":"A Dittberner","year":"2020","unstructured":"Dittberner, A. et al. Gender disparities in epidemiology, treatment, and outcome for head and neck cancer in Germany: A population-based long-term analysis from 1996 to 2016 of the Thuringian Cancer Registry. Cancers. https:\/\/doi.org\/10.3390\/cancers12113418 (2020).","journal-title":"Cancers."},{"key":"58423_CR15","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14133099","author":"M Kouka","year":"2022","unstructured":"Kouka, M. et al. Early mortality among patients with head and neck cancer diagnosed in Thuringia, Germany, between 1996 and 2016\u2014A population-based study. Cancers. https:\/\/doi.org\/10.3390\/cancers14133099 (2022).","journal-title":"Cancers."},{"key":"58423_CR16","doi-asserted-by":"publisher","first-page":"3260","DOI":"10.1002\/cam4.882","volume":"5","author":"I Goellnitz","year":"2016","unstructured":"Goellnitz, I. et al. Role of comorbidity on outcome of head and neck cancer: A population-based study in Thuringia, Germany. Cancer Med. 5, 3260\u20133271. https:\/\/doi.org\/10.1002\/cam4.882 (2016).","journal-title":"Cancer Med."},{"key":"58423_CR17","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-021-03535-4","author":"L Morkramer","year":"2021","unstructured":"Morkramer, L. et al. Systemic therapy for recurrent and\/or metastatic head and neck cancer: A population-based healthcare research study in Thuringia, Germany. J. Cancer Res. Clin. Oncol. https:\/\/doi.org\/10.1007\/s00432-021-03535-4 (2021).","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"58423_CR18","doi-asserted-by":"publisher","first-page":"2707","DOI":"10.1002\/lary.24658","volume":"124","author":"CB O'Neill","year":"2014","unstructured":"O\u2019Neill, C. B. et al. Treatment complications and survival in advanced laryngeal cancer: A population-based analysis. Laryngoscope 124, 2707\u20132713. https:\/\/doi.org\/10.1002\/lary.24658 (2014).","journal-title":"Laryngoscope"},{"key":"58423_CR19","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15225447","author":"AR Ritter","year":"2023","unstructured":"Ritter, A. R. et al. Factors associated with total laryngectomy utilization in patients with cT4a laryngeal cancer. Cancers. https:\/\/doi.org\/10.3390\/cancers15225447 (2023).","journal-title":"Cancers."},{"key":"58423_CR20","doi-asserted-by":"publisher","first-page":"2611","DOI":"10.1002\/lary.28452","volume":"130","author":"CG Hochfelder","year":"2020","unstructured":"Hochfelder, C. G. et al. Treatment sequence and survival in locoregionally advanced hypopharyngeal cancer: A surveillance, epidemiology, and end results-based study. Laryngoscope 130, 2611\u20132621. https:\/\/doi.org\/10.1002\/lary.28452 (2020).","journal-title":"Laryngoscope"},{"issue":"Suppl 1","key":"58423_CR21","doi-asserted-by":"publisher","first-page":"E1247","DOI":"10.1002\/hed.24200","volume":"38","author":"AJ Timmermans","year":"2016","unstructured":"Timmermans, A. J. et al. Trends in treatment and survival for advanced laryngeal cancer: A 20-year population-based study in The Netherlands. Head neck 38(Suppl 1), E1247-1255. https:\/\/doi.org\/10.1002\/hed.24200 (2016).","journal-title":"Head neck"},{"key":"58423_CR22","doi-asserted-by":"publisher","first-page":"3745","DOI":"10.1007\/s00405-023-07983-1","volume":"280","author":"Z Song","year":"2023","unstructured":"Song, Z., Chen, Z., Sun, X. & Zou, L. Competing risk models versus traditional Cox models for prognostic factors\u2019 prediction and care recommendation in patients with advanced laryngeal squamous carcinoma: A population-based study. Eur. Arch. Oto-rhino-laryngol. 280, 3745\u20133756. https:\/\/doi.org\/10.1007\/s00405-023-07983-1 (2023).","journal-title":"Eur. Arch. Oto-rhino-laryngol."},{"key":"58423_CR23","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1002\/lio2.1034","volume":"8","author":"R Blomkvist","year":"2023","unstructured":"Blomkvist, R. et al. Treatment and outcome among patients with laryngeal squamous cell carcinoma in Stockholm\u2014A population-based study. Laryngosc. Investig. Otolaryngol. 8, 441\u2013449. https:\/\/doi.org\/10.1002\/lio2.1034 (2023).","journal-title":"Laryngosc. Investig. Otolaryngol."},{"key":"58423_CR24","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1007\/s10147-020-01688-9","volume":"25","author":"X Zhu","year":"2020","unstructured":"Zhu, X. et al. Survival prediction and treatment strategies for patients with advanced laryngeal carcinoma: A population-based study. Int. J. Clin. Oncol. 25, 1483\u20131491. https:\/\/doi.org\/10.1007\/s10147-020-01688-9 (2020).","journal-title":"Int. J. Clin. Oncol."},{"key":"58423_CR25","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1002\/lary.21348","volume":"121","author":"CG Gourin","year":"2011","unstructured":"Gourin, C. G. et al. Impact of surgeon and hospital volume on short-term outcomes and cost of laryngeal cancer surgical care. Laryngoscope 121, 85\u201390. https:\/\/doi.org\/10.1002\/lary.21348 (2011).","journal-title":"Laryngoscope"},{"key":"58423_CR26","doi-asserted-by":"publisher","first-page":"2409","DOI":"10.1002\/hed.25363","volume":"40","author":"SN Helman","year":"2018","unstructured":"Helman, S. N. et al. Factors associated with complications in total laryngectomy without microvascular reconstruction. Head Neck 40, 2409\u20132415. https:\/\/doi.org\/10.1002\/hed.25363 (2018).","journal-title":"Head Neck"},{"key":"58423_CR27","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1097\/00020840-200106000-00004","volume":"9","author":"PA Sullivan","year":"2001","unstructured":"Sullivan, P. A. & Hartig, G. K. Dysphagia after total laryngectomy. Curr. Opin. Otolaryngol. Head Neck Surg. 9, 139\u2013146 (2001).","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"key":"58423_CR28","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.oraloncology.2018.08.023","volume":"86","author":"J Zenga","year":"2018","unstructured":"Zenga, J., Goldsmith, T., Bunting, G. & Deschler, D. G. State of the art: Rehabilitation of speech and swallowing after total laryngectomy. Oral Oncol. 86, 38\u201347. https:\/\/doi.org\/10.1016\/j.oraloncology.2018.08.023 (2018).","journal-title":"Oral Oncol."},{"key":"58423_CR29","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1002\/lary.30166","volume":"133","author":"DS Lee","year":"2023","unstructured":"Lee, D. S. et al. Risk factors for functional outcomes in advanced laryngeal squamous cell carcinoma. Laryngoscope 133, 594\u2013600. https:\/\/doi.org\/10.1002\/lary.30166 (2023).","journal-title":"Laryngoscope"},{"key":"58423_CR30","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s00405-017-4790-6","volume":"275","author":"KE van Sluis","year":"2018","unstructured":"van Sluis, K. E. et al. Objective and subjective voice outcomes after total laryngectomy: A systematic review. Eur. Arch. Oto-rhino-laryngol. 275, 11\u201326. https:\/\/doi.org\/10.1007\/s00405-017-4790-6 (2018).","journal-title":"Eur. Arch. Oto-rhino-laryngol."},{"key":"58423_CR31","doi-asserted-by":"publisher","first-page":"2320","DOI":"10.1002\/lary.27066","volume":"128","author":"RKV Sethi","year":"2018","unstructured":"Sethi, R. K. V. & Deschler, D. G. National trends in primary tracheoesophageal puncture after total laryngectomy. Laryngoscope 128, 2320\u20132325. https:\/\/doi.org\/10.1002\/lary.27066 (2018).","journal-title":"Laryngoscope"},{"key":"58423_CR32","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1001\/jamaoto.2016.2771","volume":"143","author":"JS Lewin","year":"2017","unstructured":"Lewin, J. S., Baumgart, L. M., Barrow, M. P. & Hutcheson, K. A. Device life of the tracheoesophageal voice prosthesis revisited. JAMA Otolaryngol. Head Neck Surg. 143, 65\u201371. https:\/\/doi.org\/10.1001\/jamaoto.2016.2771 (2017).","journal-title":"JAMA Otolaryngol. Head Neck Surg."},{"key":"58423_CR33","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1002\/lary.20925","volume":"120","author":"FJ Hilgers","year":"2010","unstructured":"Hilgers, F. J. et al. Prospective clinical phase II study of two new indwelling voice prostheses (Provox Vega 22.5 and 20 Fr) and a novel anterograde insertion device (Provox Smart Inserter). Laryngoscope. 120, 1135\u20131143. https:\/\/doi.org\/10.1002\/lary.20925 (2010).","journal-title":"Laryngoscope."},{"key":"58423_CR34","doi-asserted-by":"publisher","first-page":"e535","DOI":"10.1055\/s-0039-3402497","volume":"24","author":"I Brook","year":"2020","unstructured":"Brook, I. & Goodman, J. F. Tracheoesophageal voice prosthesis use and maintenance in laryngectomees. Int. Arch. Otorhinolaryngol. 24, e535\u2013e538. https:\/\/doi.org\/10.1055\/s-0039-3402497 (2020).","journal-title":"Int. Arch. Otorhinolaryngol."},{"key":"58423_CR35","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1007\/s00405-012-2154-9","volume":"270","author":"KL Hancock","year":"2013","unstructured":"Hancock, K. L., Lawson, N. R. & Ward, E. C. Device life of the Provox Vega voice prosthesis. Eur. Arch. Oto-rhino-laryngol. 270, 1447\u20131453. https:\/\/doi.org\/10.1007\/s00405-012-2154-9 (2013).","journal-title":"Eur. Arch. Oto-rhino-laryngol."},{"key":"58423_CR36","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1177\/01945998221116815","volume":"168","author":"AN Heirman","year":"2023","unstructured":"Heirman, A. N. et al. Does prophylactic replacement of voice prosthesis make sense? A study to predict prosthesis lifetime. Otolaryngol. Head Neck Surg. 168, 429\u2013434. https:\/\/doi.org\/10.1177\/01945998221116815 (2023).","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"58423_CR37","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1001\/archotol.126.11.1320","volume":"126","author":"BM Op de Coul","year":"2000","unstructured":"Op de Coul, B. M. et al. A decade of postlaryngectomy vocal rehabilitation in 318 patients: A single Institution\u2019s experience with consistent application of provox indwelling voice prostheses. Arch. Otolaryngol. Head Neck Surg. 126, 1320\u20131328. https:\/\/doi.org\/10.1001\/archotol.126.11.1320 (2000).","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"58423_CR38","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1002\/hed.25364","volume":"41","author":"JF Petersen","year":"2019","unstructured":"Petersen, J. F. et al. Postlaryngectomy prosthetic voice rehabilitation outcomes in a consecutive cohort of 232 patients over a 13-year period. Head Neck 41, 623\u2013631. https:\/\/doi.org\/10.1002\/hed.25364 (2019).","journal-title":"Head Neck"},{"key":"58423_CR39","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1002\/lary.26454","volume":"127","author":"SN Helman","year":"2017","unstructured":"Helman, S. N. et al. Predictors of length of stay, reoperation, and readmission following total laryngectomy. Laryngoscope 127, 1339\u20131344. https:\/\/doi.org\/10.1002\/lary.26454 (2017).","journal-title":"Laryngoscope"},{"key":"58423_CR40","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-023-08180-w","author":"RC Pires","year":"2023","unstructured":"Pires, R. C. et al. Analysis of durability and replacement of vocal prostheses in total laryngectomy patients at a head and neck surgery referral center. Eur. Arch. Oto-rhino-laryngol. https:\/\/doi.org\/10.1007\/s00405-023-08180-w (2023).","journal-title":"Eur. Arch. Oto-rhino-laryngol."},{"key":"58423_CR41","doi-asserted-by":"publisher","first-page":"3042","DOI":"10.1002\/hed.27532","volume":"45","author":"C Sampieri","year":"2023","unstructured":"Sampieri, C. et al. Predicting the need for prophylactic gastrostomy in major head and neck cancer surgery: The PEG score. Head Neck 45, 3042\u20133052. https:\/\/doi.org\/10.1002\/hed.27532 (2023).","journal-title":"Head Neck"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-58423-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-58423-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-58423-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T13:06:12Z","timestamp":1712063172000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-58423-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,2]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["58423"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-58423-x","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,2]]},"assertion":[{"value":"13 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"7761"}}