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Somatostatin 4 receptor (SSTR4) has been shown to mediate anxiolytic and depression-like effects. Here, we aimed to explore the potential of SSTR4 as a diagnostic marker for chronic stress in mice. The mice were divided into single stress, chronic restraint stress, and control groups, and <jats:italic>Sstr4<\/jats:italic> mRNA expression in the pituitary, lungs, and thymus, its protein expression in the thymus, were analyzed. Compared to controls, <jats:italic>Sstr4<\/jats:italic> mRNA expression decreased significantly in the pituitary gland of the chronic and single-stress groups (P\u2009=\u20090.0181 and 0.0022, respectively) and lungs of the single-stress group (P\u2009=\u20090.0124), whereas it significantly increased in the thymus of the chronic-stress group (P\u2009=\u20090.0313). Thymic SSTR4 expression did not decrease significantly in stress groups compared to that in the control group (P\u2009=\u20090.0963). These results suggest that SSTR4 expression fluctuates in response to stress. Furthermore, <jats:italic>Sstr4<\/jats:italic> mRNA expression dynamics in each organ differed based on single or chronic restraint stress-loading periods. In conclusion, this study suggests that investigating SSTR4 expression in each organ could allow for its use as a stress marker to estimate the stress-loading period and aid in diagnosing chronic stress.<\/jats:p>","DOI":"10.1038\/s41598-024-58621-7","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T04:01:50Z","timestamp":1714622510000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dynamics of somatostatin 4 receptor expression during chronic-stress loading and its potential as a chronic-stress marker"],"prefix":"10.1038","volume":"14","author":[{"given":"Yuki","family":"Abe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiko","family":"Murase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahide","family":"Mitsuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoriko","family":"Shinba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Ikematsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,5,2]]},"reference":[{"key":"58621_CR1","first-page":"46","volume":"15","author":"S Noushad","year":"2021","unstructured":"Noushad, S. et al. 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