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Meanwhile, the topical wound irrigation solution consisting of polyhexamethylene biguanide and betaine (PHMB-B) has shown efficacy in managing wound infections. However, the effectiveness of this solution as a topical instillation solution for NPWTi-d in patients with diabetic foot infections (DFIs) has not been thoroughly studied. The objective of this retrospective study was to evaluate the impact of using PHMB-B as the instillation solution during NPWTi-d on reducing bioburden and improving clinical outcomes in patients with DFIs. Between January 2017 and December 2022, a series of patients with DFIs received treatment with NPWTi-d, using either PHMB-B or normal saline as the instillation solution. Data collected retrospectively included demographic information, baseline wound characteristics, and treatment outcomes. The study included 61 patients in the PHMB-B group and 73 patients in the normal saline group, all diagnosed with DFIs. In comparison to patients treated with normal saline, patients with PHMB-B exhibited no significant differences in terms of wound bed preparation time (<jats:italic>P<\/jats:italic>\u2009=\u20090.5034), length of hospital stay (<jats:italic>P<\/jats:italic>\u2009=\u20090.6783), NPWTi-d application times (<jats:italic>P<\/jats:italic>\u2009=\u20090.1458), duration of systematic antimicrobial administration (<jats:italic>P<\/jats:italic>\u2009=\u20090.3567), or overall cost of hospitalization (<jats:italic>P<\/jats:italic>\u2009=\u20090.6713). The findings of the study suggest that the use of either PHMB-B or normal saline as an instillation solution in NPWTi-d for DFIs shows promise and effectiveness, yet no clinical distinction was observed between the two solutions.<\/jats:p>","DOI":"10.1038\/s41598-024-58900-3","type":"journal-article","created":{"date-parts":[[2024,5,19]],"date-time":"2024-05-19T16:01:27Z","timestamp":1716134487000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Assessment between antiseptic and normal saline for negative pressure wound therapy with instillation and dwell time in diabetic foot infections"],"prefix":"10.1038","volume":"14","author":[{"given":"Jingchun","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,19]]},"reference":[{"issue":"2","key":"58900_CR1","doi-asserted-by":"publisher","first-page":"92","DOI":"10.36290\/vnl.2020.015","volume":"66","author":"R B\u00e9m","year":"2020","unstructured":"B\u00e9m, R., Dubsk\u00fd, M., Fejfarov\u00e1, V., Hus\u00e1kov\u00e1, J. & Woskov\u00e1, V. 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