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Platelet derived growth factor \u03b2 (PDGFR\u03b2) lineage cells, that co-express PDGFR\u03b1 have previously been shown to directly contribute to scar formation and fat accumulation in a mouse model of irreversible tendon and nerve transection (TTDN). Conversely, PDGFR\u03b2<jats:sup>+<\/jats:sup> lineage cells have also\u00a0been\u00a0 shown to be myogenic in cultures and in other models of skeletal muscle injury. We therefore hypothesized that PDGFR\u03b2 demarcates two distinct RC residing subpopulations, fibro-adipogenic and myogenic, and aimed to elucidate the identity of the PDGFR\u03b2 myogenic precursors and evaluate their contribution, if any, to RC myo-regeneration. Lineage tracing revealed increasing contribution of PDGFR\u03b2<jats:sup>+<\/jats:sup> myo-progenitors to the formation of GFP<jats:sup>+<\/jats:sup> myofibers, which were the most abundant myofiber type in regenerated muscle at 2\u00a0weeks post-TTDN. Muscle regeneration preceded muscle atrophy and both advanced from the lateral site of tendon transection to the farthest medial region. GFP<jats:sup>+<\/jats:sup>\/PDGFR\u03b2<jats:sup>+<\/jats:sup>Sca-1<jats:sup>\u2212<\/jats:sup>lin<jats:sup>\u2212<\/jats:sup>CXCR4<jats:sup>+<\/jats:sup>Integrin-\u03b21<jats:sup>+<\/jats:sup> marked a novel subset of satellite cells with confirmed myogenic properties. Further studies are warranted to identify the existence of PDGFR\u03b2<jats:sup>+<\/jats:sup> satellite cells in human and other mouse muscles and to define their myo-regenerative potential following acute and chronic muscle injury.<\/jats:p>","DOI":"10.1038\/s41598-024-58926-7","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T21:01:22Z","timestamp":1714165282000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Lineage tracing reveals a novel PDGFR\u03b2+ satellite cell subset that contributes to myo-regeneration of chronically injured rotator cuff muscle"],"prefix":"10.1038","volume":"14","author":[{"given":"Ayelet","family":"Dar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank A.","family":"Petrigliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,26]]},"reference":[{"key":"58926_CR1","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1177\/0363546518762386","volume":"46","author":"HY Jeong","year":"2018","unstructured":"Jeong, H. 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