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NdS\/549728\/2022\/20222 of November 2, 2022 amount co-financing PLN 1,013,150.00 total project value PLN 1,013,150.00, Polska"],"award-info":[{"award-number":["Project \"Science for Society\", project entitled: \"Use of heated tobacco - health and social aspects\" project no. NdS\/549728\/2022\/20222 of November 2, 2022 amount co-financing PLN 1,013,150.00 total project value PLN 1,013,150.00, Polska"]}],"id":[{"id":"10.13039\/501100004569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Heated tobacco products (HTPs) are novel tobacco products that are alternatives to cigarettes. The study aimed to investigate the effect of HTPs on blood biomarkers of inflammation as well as to provide a comparative evaluation between daily heated tobacco users and healthy men who do not use nicotine products. This case\u2013control study was carried out among 92 healthy males in Poland (Lodz-Province) aged 20\u201356\u00a0years: 44 daily heated tobacco users (daily use in the past 90\u00a0days) and 48 controls who do not use nicotine products. The history of use of the nicotine-containing products was self-reported and verified using a saliva cotinine test. A 20\u00a0ml blood sample was collected and the levels of ten blood biomarkers were analyzed. Among all heated tobacco users (n\u2009=\u200944), only the levels of interleukin 8 (IL-8) were significantly higher when compared to controls: 6.86 vs. 3.95 (p\u2009=\u20090.01). Among exclusive heated tobacco users (n\u2009=\u200933), the levels of IL-8 were also significantly higher when compared to controls: 7.76 vs. 3.95 (p\u2009=\u20090.01). IL-8 level was positively correlated (r\u2009=\u20090.37; p\u2009=\u20090.01) with the daily number of heated tobacco sticks. 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