{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:37:58Z","timestamp":1793054278571,"version":"4.5.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Wilson\u2019s disease is caused by abnormal copper metabolism resulting in deposition in various organs, including the brain, liver, and cornea, thus disrupting organ function. It is characterized by encephalopathy, extrapyramidal symptoms, progressive liver failure, and copper ring deposition in the cornea. Management of this disease should include quality of life maintenance; however, relevant studies on this topic are lacking. This study aimed to assess the factors affecting the quality of life (QoL) of patients with Wilson\u2019s disease. A cross-sectional survey using convenience sampling was conducted between July 2020 and March 2021 at the hospital. Data on patient characteristics, 36-item Short-Form General Health Survey, Uniform Wilson Disease Rating Scale, and Hamilton Depression Rating Scale scores were collected. Associations among quality of life depression, anxiety, and Wilson\u2019s disease progression were examined using Pearson correlation analysis. Factors affecting the quality of life of patients, including depression, anxiety, liver function, clinical symptoms, diet, liver function, brain magnetic resonance imaging (MRI) findings, disease duration, Barthel Index, and Morse scores were examined using multivariate linear regression analysis. This study included 134 patients with Wilson\u2019s disease whose mean age was 29.12\u2009\u00b1\u20098.59\u00a0years. The mean QoL score in the patient group was 71.38\u2009\u00b1\u20099.55 points and was negatively correlated with anxiety (<jats:italic>r<\/jats:italic>\u2009=\u2009\u2212\u00a00.883, <jats:italic>P<\/jats:italic>\u2009=\u20090.000), depression (<jats:italic>r<\/jats:italic>\u2009=\u2009\u2212\u00a00.852 <jats:italic>P<\/jats:italic>\u2009=\u20090.000), and clinical symptoms (<jats:italic>r<\/jats:italic>\u2009=\u2009\u2212\u00a00.542, <jats:italic>P<\/jats:italic>\u2009=\u20090.000) scores. Anxiety, depression, and clinical symptoms severity are vital factors for the QoL of patients with Wilson\u2019s disease. The study provides foundational evidence to design novel interventions, including symptom management, diet, and self-care ability, which can help in improving the quality of life in patients with Wilson\u2019s disease and decreasing the burden associated with this disease.<\/jats:p>","DOI":"10.1038\/s41598-024-59377-w","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T06:02:35Z","timestamp":1713160955000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Assessment and factors affecting quality of life among patients with Wilson\u2019s disease"],"prefix":"10.1038","volume":"14","author":[{"given":"Tingting","family":"Zhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiang","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caijie","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,15]]},"reference":[{"issue":"9","key":"59377_CR1","doi-asserted-by":"publisher","first-page":"765","DOI":"10.5152\/tjg.2021.20549","volume":"32","author":"EM Y\u00fccel","year":"2021","unstructured":"Y\u00fccel, E. 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