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Participants were measured for LDL-p through nuclear magnetic resonance technology. 740 men participated in follow-up and underwent 1.5\u00a0T brain magnetic resonance angiography from 2012 to 2015. Participants were categorized as no-ICAS, and ICAS consisted of mild-ICAS (1 to\u2009&lt;\u200950%) and severe-ICAS (\u2265\u200950%) in any of the arteries examined. After exclusion criteria, 711 men left for analysis, we used multiple logistic regression to examine the association between lipid profiles and ICAS prevalence. Among the study participants, 205 individuals (28.8%) had ICAS, while 144 individuals (20.3%) demonstrated discordance between LDL-c and LDL-p levels. The discordance \u201clow LDL-c\u2013high LDL-p\u201d group had the highest ICAS risk with an adjusted OR (95% CI) of 2.78 (1.55\u20135.00) in the reference of the concordance \u201clow LDL-c\u2013low LDL-p\u201d group. 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