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We assessed the association between discrimination and depression, anxiety, and loneliness symptoms among Asian or Pacific Islander adults (n\u2009=\u2009543) using data from a 116-item nationally distributed online survey of adults (\u2265\u200918\u00a0years old) in the United States conducted between 5\/2021\u20131\/2022. Discrimination was assessed using the 5-item Everyday Discrimination Scale. Anxiety, depression, and loneliness symptoms were assessed using the 2-item Generalized Anxiety Disorder, 2-item Patient Health Questionnaire, and UCLA Loneliness Scale\u2014Short form, respectively. We used multivariable logistic regression to estimate the association between discrimination and mental health. Overall, 42.7% of participants reported experiencing discrimination once a month or more. Compared with no discrimination, experiencing discrimination once a month was associated with increased odds of anxiety (Adjusted Odds Ratio [aOR]\u2009=\u20092.60, 95% CI\u2009=\u20091.38\u20134.77), depression (aOR\u2009=\u20092.58, 95% CI\u2009=\u20091.46\u20134.56), and loneliness (aOR\u2009=\u20092.86, 95% CI\u2009=\u20091.75\u20134.67). Experiencing discrimination once a week or more was associated with even higher odds of anxiety (aOR\u2009=\u20096.90, 95% CI\u2009=\u20093.71\u201312.83), depression, (aOR\u2009=\u20096.96, 95% CI\u2009=\u20093.80\u201312.74), and loneliness (aOR\u2009=\u20096.91, 95% CI\u2009=\u20093.38\u201313.00). Discrimination is detrimental to mental health, even at relatively low frequencies; however, more frequent discrimination was associated with worse mental health symptoms. Public health interventions and programs targeting anti-A\/PI hate and reducing A\/PI mental health burden are urgently needed.<\/jats:p>","DOI":"10.1038\/s41598-024-59543-0","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T10:01:49Z","timestamp":1713952909000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Discrimination is associated with depression, anxiety, and loneliness symptoms among Asian and Pacific Islander adults during COVID-19 Pandemic"],"prefix":"10.1038","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3598-616X","authenticated-orcid":false,"given":"Cameron K.","family":"Ormiston","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1072-1560","authenticated-orcid":false,"given":"Paula D.","family":"Strassle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Boyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7960-2463","authenticated-orcid":false,"given":"Faustine","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,24]]},"reference":[{"key":"59543_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2021.114084","volume":"303","author":"HC Hahm","year":"2021","unstructured":"Hahm, H. 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