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However, there is currently a lack of studies investigating the association between peHR and patients with acute pancreatitis. Multiparameter Intelligent Monitoring in Intensive Care IV (MIMIC-IV) database was used to identify patients with acute pancreatitis. PeHR was defined as a heart rate exceeding 100 beats per minute for at least 11 out of 12 consecutive hours. Cox regression analysis was used to assess the association between peHR and the 90-Day mortality. A total of 364 patients (48.9%) experienced a peHR episode. The 90-day mortality was 25%. PeHR is an independent risk factor for 90-day mortality (HR, 1.98; 95% CI 1.53\u20132.56; P\u2009&lt;\u20090.001). KM survival curves exhibited a significant decrease in the survival rate at 90\u00a0days among patients who experienced a peHR episode (P\u2009&lt;\u20090.001, 84.5% vs. 65.1%). We revealed a significant association of peHR with decreased survival in a large cohort of ICU patients with acute pancreatitis.<\/jats:p>","DOI":"10.1038\/s41598-024-59557-8","type":"journal-article","created":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T14:01:22Z","timestamp":1714312882000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prolonged elevated heart rate and 90-Day mortality in acute pancreatitis"],"prefix":"10.1038","volume":"14","author":[{"given":"Shan","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuxing","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuobei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhili","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenglong","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,28]]},"reference":[{"key":"59557_CR1","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1177\/0885066618756828","volume":"34","author":"V Sandfort","year":"2019","unstructured":"Sandfort, V., Johnson, A. 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