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The association between admission laboratory blood test indicators and the occurrence of ACS in patients with tibial diaphysis fractures is currently a subject of debate. The objective of this research was to identify the contributing factors for ACS in individuals suffering from tibial diaphysis fractures. In this retrospective study, we collected data on a total of 705 individuals from our hospital, comprising 86 ACS patients and 619 non-ACS patients with tibial diaphysis fractures. These participants were categorized into two distinct groups: the ACS group and the non-ACS group. Despite the inherent limitations associated with retrospective analyses, such as potential biases in data collection and interpretation, we conducted a comprehensive analysis of demographics, comorbidities, and admission lab results. Our analytical approach included univariate analysis, logistic regression, and receiver operating characteristic (ROC) curve analysis techniques, aiming to mitigate these limitations and provide robust findings. The statistical analysis revealed several predictors of ACS, including gender (p\u2009=\u20090.011, OR\u2009=\u20093.200), crush injuries (p\u2009=\u20090.004, OR\u2009=\u20094.622), lactic dehydrogenase (LDH) levels (p\u2009&lt;\u20090.001, OR\u2009=\u20091.003), and white blood cell (WBC) count (p\u2009&lt;\u20090.001, OR\u2009=\u20091.246). Interestingly, the study also found that certain factors, such as falls on the same level (p\u2009=\u20090.007, OR\u2009=\u20090.334) and cholinesterase (CHE) levels (p\u2009&lt;\u20090.001, OR\u2009=\u20090.721), seem to provide a degree of protection against ACS. In order to better predict ACS, the ROC curve analysis was employed, which determined threshold values for LDH and WBC. The established cut-off points were set at 266.26 U\/L for LDH and 11.7\u2009\u00d7\u200910<jats:sup>9<\/jats:sup> cells per liter for WBC, respectively. Our research has successfully pinpointed gender, crush injuries, LDH levels, and white blood cell (WBC) count as crucial risk factors for the development of ACS in patients experiencing tibial diaphysis fractures. Furthermore, by establishing the cut-off values for LDH and WBC, we have facilitated a more personalized assessment of ACS risk, enabling clinical doctors to implement targeted early interventions and optimize patient outcomes.<\/jats:p>","DOI":"10.1038\/s41598-024-59669-1","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T20:19:47Z","timestamp":1713385187000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Identifying key risk factors for acute compartment syndrome in tibial diaphysis fracture patients"],"prefix":"10.1038","volume":"14","author":[{"given":"Ming","family":"An","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruili","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leilei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubin","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"key":"59669_CR1","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.2106\/00004623-199072100-00006","volume":"72","author":"SL Buckley","year":"1990","unstructured":"Buckley, S. 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