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Before invasive testing, three CT ratio techniques and other ultrasound markers were obtained in 151 singleton pregnancies at risk of Hb Bart\u2019s disease. CT diameter ratio demonstrated the highest sensitivity among the other techniques. Significant predictors included CT diameter ratio\u2009&gt;\u20090.5, middle cerebral artery-peak systolic velocity (MCA-PSV)\u2009&gt;\u20091.5 multiples of the median, and placental thickness\u2009&gt;\u20093\u00a0cm. MCA-PSV exhibited the highest sensitivity (97.8%) in predicting affected fetuses. A multivariable scoring achieved excellent sensitivity (100%) and specificity (84.9%) for disease prediction. CT diameter ratio exhibited slightly outperforming the other techniques. Increased MCA-PSV was the most valuable ultrasound marker. Multivariable scoring surpassed single-parameter analysis in predictive capabilities.<\/jats:p>","DOI":"10.1038\/s41598-024-59719-8","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T17:02:07Z","timestamp":1713373327000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparing three cardiothoracic ratio measurement techniques and creating multivariable scoring system to predict Bart\u2019s hydrops fetalis at 17\u201322\u00a0weeks\u2019 gestation"],"prefix":"10.1038","volume":"14","author":[{"given":"Sanitra","family":"Anuwutnavin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patsawee","family":"Rangseechamrat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nalat","family":"Sompagdee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pornpimol","family":"Ruangvutilert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sommai","family":"Viboonchard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"key":"59719_CR1","doi-asserted-by":"publisher","first-page":"65","DOI":"10.3109\/03630268709036587","volume":"11","author":"S Fucharoen","year":"1987","unstructured":"Fucharoen, S. & Winichagoon, P. 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