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A total of 93 feet of 83 consecutive patients with DFI who underwent WBC SPECT\/CT for treatment planning were retrospectively analysed. The clinical and SPECT\/CT parameters were collected along with the measurements of the maximum standardized uptake value (SUVmax) at DFI. Statistical logistic regression analysis was performed to explore the predictors of LEA and receiver operating characteristic (ROC)\u00a0curve was analysed to assess the predictive value of SPECT\/CT. The independent predictors of amputation were previous amputation (OR 11.9), numbers of SPECT\/CT lesions (OR 2.1), and SUVmax of DFI; either continuous SUVmax (1-increase) (OR 1.3) or categorical SUVmax\u2009&gt;\u20091.1 (OR 21.6). However, the conventional SPECT\/CT interpretation failed to predict amputation. In ROC analysis, the SUVmax yielded a fair predictor (area under the curve (AUC) 0.782) of amputation. The model developed from these independent predictors yielded an excellent performance for predicting amputation (AUC 0.873). Quantitative WBC SPECT\/CT can provide new information useful for predicting the outcomes and guiding treatment for patients with DFI.<\/jats:p>","DOI":"10.1038\/s41598-024-59764-3","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T19:01:35Z","timestamp":1713812495000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The usefulness of quantitative 99mTc-HMPAO WBC SPECT\/CT for predicting lower extremity amputation in diabetic foot infection"],"prefix":"10.1038","volume":"14","author":[{"given":"Soo Bin","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chae Hong","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-il","family":"Chun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Jae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Hyong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Mi","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,22]]},"reference":[{"key":"59764_CR1","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1111\/dom.12190","volume":"16","author":"I U\u00e7kay","year":"2014","unstructured":"U\u00e7kay, I., Gariani, K., Pataky, Z. & Lipsky, B. 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