{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T02:04:07Z","timestamp":1793325847224,"version":"4.5.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["12S4222N"],"award-info":[{"award-number":["12S4222N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["1277222N"],"award-info":[{"award-number":["1277222N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007660","name":"Universiteit Antwerpen","doi-asserted-by":"publisher","award":["BOF-KP PS ID 43829"],"award-info":[{"award-number":["BOF-KP PS ID 43829"]}],"id":[{"id":"10.13039\/501100007660","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007660","name":"Universiteit Antwerpen","doi-asserted-by":"publisher","award":["BOF-KP PS ID 46355"],"award-info":[{"award-number":["BOF-KP PS ID 46355"]}],"id":[{"id":"10.13039\/501100007660","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Research Council (ERC) starting grant Lacto-Be 26850"},{"DOI":"10.13039\/501100007660","name":"Universiteit Antwerpen","doi-asserted-by":"publisher","award":["PS ID 46355"],"award-info":[{"award-number":["PS ID 46355"]}],"id":[{"id":"10.13039\/501100007660","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007660","name":"Universiteit Antwerpen","doi-asserted-by":"publisher","award":["PS ID 43829"],"award-info":[{"award-number":["PS ID 43829"]}],"id":[{"id":"10.13039\/501100007660","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Lesaffre International"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Strategies against the opportunistic fungal pathogen<jats:italic> Candida albicans<\/jats:italic> based on probiotic microorganisms represent a promising alternative to traditional antifungals. Here, we investigated the effects of <jats:italic>Lactobacillaceae<\/jats:italic> isolates from fermented foods or the\u00a0human vagina, alone or in combination with the probiotic yeast <jats:italic>Saccharomyces cerevisiae<\/jats:italic> CNCM I-3856, against <jats:italic>C. albicans <\/jats:italic>in vitro. Nine out of nineteen tested strains of <jats:italic>Lactobacillaceae<\/jats:italic> inhibited growth of <jats:italic>C. albicans<\/jats:italic> with inhibition zones of 1\u20133\u00a0mm in spot assays. Five out of nineteen lactobacilli tested\u00a0as such or in combination with <jats:italic>S. cerevisiae<\/jats:italic> CNCM I-3856 also significantly inhibited <jats:italic>C. albicans<\/jats:italic> hyphae formation, including <jats:italic>Limosilactobacillus fermentum<\/jats:italic> LS4 and <jats:italic>L. fermentum<\/jats:italic> LS5 resulting in respectively 62% and 78% hyphae inhibition compared to the control. Thirteen of the tested nineteen lactobacilli aggregated with the yeast form of <jats:italic>C. albicans<\/jats:italic>, with <jats:italic>Lactiplantibacillus carotarum<\/jats:italic> AMBF275 showing the strongest aggregation. The aggregation was enhanced when lactobacilli were combined with <jats:italic>S. cerevisiae<\/jats:italic> CNCM I-3856. No significant antagonistic effects were observed\u00a0between the tested lactobacilli and S. cerevisiae CNCM I-3856. The multifactorial activity of <jats:italic>Lactobacillaceae<\/jats:italic> strains alone or combined with the probiotic <jats:italic>S. cerevisiae<\/jats:italic> CNCM I-3856 against <jats:italic>C. albicans<\/jats:italic> without antagonistic effects\u00a0between the beneficial strains, paves the way for developing consortium probiotics for in vivo applications.<\/jats:p>","DOI":"10.1038\/s41598-024-59869-9","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T18:03:04Z","timestamp":1713895384000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Multifactorial inhibition of Candida albicans by combinations of lactobacilli and probiotic Saccharomyces cerevisiae CNCM I-3856"],"prefix":"10.1038","volume":"14","author":[{"given":"Irina","family":"Spacova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille Nina","family":"Allonsius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilke","family":"De Boeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eline","family":"Oerlemans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Tuyaerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nele","family":"Van de Vliet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne F. L.","family":"van den Broek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Jimenez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micka\u00ebl","family":"Boyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Ballet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9400-6918","authenticated-orcid":false,"given":"Sarah","family":"Lebeer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,23]]},"reference":[{"key":"59869_CR1","doi-asserted-by":"publisher","first-page":"fuaa060","DOI":"10.1093\/femsre\/fuaa060","volume":"45","author":"C d\u2019Enfert","year":"2021","unstructured":"d\u2019Enfert, C. et al. The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: Current knowledge and new perspectives. FEMS Microbiol. Rev. 45, fuaa060 (2021).","journal-title":"FEMS Microbiol. Rev."},{"key":"59869_CR2","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s12905-019-0748-8","volume":"19","author":"J Yano","year":"2019","unstructured":"Yano, J. et al. Current patient perspectives of vulvovaginal candidiasis: Incidence, symptoms, management and post-treatment outcomes. BMC Womens Health 19, 48 (2019).","journal-title":"BMC Womens Health"},{"key":"59869_CR3","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1186\/s12905-022-01741-x","volume":"22","author":"K Benedict","year":"2022","unstructured":"Benedict, K., Singleton, A. L., Jackson, B. R. & Molinari, N. A. M. Survey of incidence, lifetime prevalence, and treatment of self-reported vulvovaginal candidiasis, United States, 2020. BMC Womens Health 22, 147 (2022).","journal-title":"BMC Womens Health"},{"key":"59869_CR4","doi-asserted-by":"publisher","first-page":"980","DOI":"10.3389\/fmicb.2018.00980","volume":"9","author":"S Patil","year":"2018","unstructured":"Patil, S., Majumdar, B., Sarode, S. C., Sarode, G. S. & Awan, K. H. Oropharyngeal candidosis in HIV-infected patients\u2014an update. Front. Microbiol. 9, 980 (2018).","journal-title":"Front. Microbiol."},{"key":"59869_CR5","doi-asserted-by":"publisher","first-page":"805527","DOI":"10.3389\/fped.2021.805527","volume":"9","author":"Z Rafat","year":"2021","unstructured":"Rafat, Z. et al. The prevalence, etiological agents, clinical features, treatment, and diagnosis of HIV-associated oral candidiasis in pediatrics across the world: A systematic review and meta-analysis. Front. Pediatr. 9, 805527. https:\/\/doi.org\/10.3389\/fped.2021.805527 (2021).","journal-title":"Front. Pediatr."},{"key":"59869_CR6","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.cmi.2019.03.028","volume":"25","author":"KE Pristov","year":"2019","unstructured":"Pristov, K. E. & Ghannoum, M. A. Resistance of Candida to azoles and echinocandins worldwide. Clin. Microbiol. Infect. 25, 792\u2013798 (2019).","journal-title":"Clin. Microbiol. Infect."},{"key":"59869_CR7","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1007\/s40265-019-01127-8","volume":"79","author":"LL Benitez","year":"2019","unstructured":"Benitez, L. L. & Carver, P. L. Adverse effects associated with long-term administration of azole antifungal agents. Drugs 79, 833\u2013853 (2019).","journal-title":"Drugs"},{"key":"59869_CR8","doi-asserted-by":"publisher","first-page":"e339","DOI":"10.1016\/S1473-3099(18)30103-8","volume":"18","author":"DW Denning","year":"2018","unstructured":"Denning, D. W., Kneale, M., Sobel, J. D. & Rautemaa-Richardson, R. Global burden of recurrent vulvovaginal candidiasis: A systematic review. Lancet Infect. Dis. 18, e339\u2013e347 (2018).","journal-title":"Lancet Infect. Dis."},{"key":"59869_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-020-64705-x","volume":"10","author":"EFM Oerlemans","year":"2020","unstructured":"Oerlemans, E. F. M. et al. Impact of a lactobacilli-containing gel on vulvovaginal candidosis and the vaginal microbiome. Sci. Rep. 10, 1\u201310 (2020).","journal-title":"Sci. Rep."},{"key":"59869_CR10","doi-asserted-by":"publisher","first-page":"8249","DOI":"10.1080\/10408398.2021.1926905","volume":"62","author":"JC Andrade","year":"2022","unstructured":"Andrade, J. C., Kumar, S., Kumar, A., \u010cern\u00e1kov\u00e1, L. & Rodrigues, C. F. Application of probiotics in candidiasis management. Crit. Rev. Food Sci. Nutr. 62, 8249\u20138264 (2022).","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"59869_CR11","first-page":"262","volume":"22","author":"R Vladareanu","year":"2018","unstructured":"Vladareanu, R. et al. New evidence on oral L. plantarum P17630 product in women with history of recurrent vulvovaginal candidiasis (RVVC): A randomized double-blind placebo-controlled study. Eur. Rev. Med. Pharmacol. Sci. 22, 262\u2013267 (2018).","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"59869_CR12","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1007\/s12602-014-9176-0","volume":"7","author":"SM Kovachev","year":"2015","unstructured":"Kovachev, S. M. & Vatcheva-Dobrevska, R. S. Local probiotic therapy for vaginal Candida albicans infections. Probiot. Antimicrob. Proteins 7, 38\u201344 (2015).","journal-title":"Probiot. Antimicrob. Proteins"},{"key":"59869_CR13","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1097\/MCG.0b013e3182684d71","volume":"46","author":"F Vicariotto","year":"2012","unstructured":"Vicariotto, F., Del Piano, M., Mogna, L. & Mogna, G. Effectiveness of the association of 2 probiotic strains formulated in a slow release vaginal product, in women affected by vulvovaginal candidiasis: A pilot study. J. Clin. Gastroenterol. 46, 73 (2012).","journal-title":"J. Clin. Gastroenterol."},{"key":"59869_CR14","doi-asserted-by":"publisher","first-page":"e0023922","DOI":"10.1128\/msphere.00239-22","volume":"7","author":"E Oerlemans","year":"2022","unstructured":"Oerlemans, E. et al. Impacts of menstruation, community type, and an oral yeast probiotic on the vaginal microbiome. mSphere 7, e0023922 (2022).","journal-title":"mSphere"},{"key":"59869_CR15","first-page":"1112","volume":"5","author":"A Cayzeele-Decherf","year":"2017","unstructured":"Cayzeele-Decherf, A., P\u00e9lerin, F. & J\u00fcsten, P. Saccharomyces cerevisiae CNCM I-3856 as a natural breakthrough for vaginal health\u202f: A clinical study. Med. J. Obstet. Gynecol. 5, 1112 (2017).","journal-title":"Med. J. Obstet. Gynecol."},{"key":"59869_CR16","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1007\/s10096-020-03868-x","volume":"39","author":"G Donders","year":"2020","unstructured":"Donders, G. et al. The use of 3 selected lactobacillary strains in vaginal probiotic gel for the treatment of acute Candida vaginitis: A proof-of-concept study. Eur. J. Clin. Microbiol. Infect. Dis. 39, 1551\u20131558 (2020).","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"59869_CR17","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1007\/s11046-018-0259-4","volume":"183","author":"Y Matsuda","year":"2018","unstructured":"Matsuda, Y., Cho, O., Sugita, T., Ogishima, D. & Takeda, S. Culture supernatants of Lactobacillus gasseri and L. crispatus Inhibit Candida albicans biofilm formation and adhesion to HeLa cells. Mycopathologia 183, 691\u2013700 (2018).","journal-title":"Mycopathologia"},{"key":"59869_CR18","doi-asserted-by":"publisher","first-page":"636474","DOI":"10.1155\/2012\/636474","volume":"2012","author":"GA K\u00f6hler","year":"2012","unstructured":"K\u00f6hler, G. A., Assefa, S. & Reid, G. Probiotic interference of Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 with the opportunistic fungal pathogen Candida albicans. Infect. Dis. Obstet. Gynecol. 2012, 636474 (2012).","journal-title":"Infect. Dis. Obstet. Gynecol."},{"key":"59869_CR19","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1111\/1751-7915.12799","volume":"10","author":"CN Allonsius","year":"2017","unstructured":"Allonsius, C. N. et al. Interplay between Lactobacillus rhamnosus GG and Candida and the involvement of exopolysaccharides. Microb. Biotechnol. 10, 1753\u20131763 (2017).","journal-title":"Microb. Biotechnol."},{"key":"59869_CR20","doi-asserted-by":"publisher","first-page":"e0131220","DOI":"10.1371\/journal.pone.0131220","volume":"10","author":"C Parolin","year":"2015","unstructured":"Parolin, C. et al. Isolation of vaginal Lactobacilli and characterization of anti-candida activity. PLoS One 10, e0131220 (2015).","journal-title":"PLoS One"},{"key":"59869_CR21","doi-asserted-by":"publisher","first-page":"2900","DOI":"10.1038\/s41598-019-39625-0","volume":"9","author":"CN Allonsius","year":"2019","unstructured":"Allonsius, C. N. et al. Inhibition of Candida albicans morphogenesis by chitinase from Lactobacillus rhamnosus GG. Sci. Rep. 9, 2900 (2019).","journal-title":"Sci. Rep."},{"key":"59869_CR22","doi-asserted-by":"publisher","first-page":"6151","DOI":"10.1038\/s41467-021-26390-w","volume":"12","author":"J MacAlpine","year":"2021","unstructured":"MacAlpine, J. et al. A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase. Nat. Commun. 12, 6151 (2021).","journal-title":"Nat. Commun."},{"key":"59869_CR23","doi-asserted-by":"publisher","first-page":"2183","DOI":"10.1038\/s41564-023-01500-0","volume":"8","author":"S Lebeer","year":"2023","unstructured":"Lebeer, S. et al. A citizen-science-enabled catalogue of the vaginal microbiome and associated factors. Nat. Microbiol. 8, 2183\u20132195 (2023).","journal-title":"Nat. Microbiol."},{"key":"59869_CR24","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1093\/jac\/dkl246","volume":"58","author":"ME Falagas","year":"2006","unstructured":"Falagas, M. E., Betsi, G. I. & Athanasiou, S. Probiotics for prevention of recurrent vulvovaginal candidiasis: A review. J. Antimicrob. Chemother. 58, 266\u2013272 (2006).","journal-title":"J. Antimicrob. Chemother."},{"key":"59869_CR25","doi-asserted-by":"publisher","first-page":"718","DOI":"10.3389\/fmicb.2020.00718","volume":"11","author":"R Gaziano","year":"2020","unstructured":"Gaziano, R., Sabbatini, S., Roselletti, E., Perito, S. & Monari, C. Saccharomyces cerevisiae-based probiotics as novel antimicrobial agents to prevent and treat vaginal infections. Front. Microbiol. 11, 718 (2020).","journal-title":"Front. Microbiol."},{"key":"59869_CR26","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1080\/21505594.2016.1213937","volume":"8","author":"E Pericolini","year":"2017","unstructured":"Pericolini, E. et al. Therapeutic activity of a Saccharomyces cerevisiae-based probiotic and inactivated whole yeast on vaginal candidiasis. Virulence 8, 74\u201390 (2017).","journal-title":"Virulence"},{"key":"59869_CR27","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3390\/nu12082211","volume":"12","author":"A Decherf","year":"2020","unstructured":"Decherf, A. et al. Recovery of Saccharomyces cerevisiae CNCM I-3856 in vaginal samples of healthy women after oral administration. Nutrients 12, 8 (2020).","journal-title":"Nutrients"},{"key":"59869_CR28","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/S0924-2244(98)00053-3","volume":"9","author":"M Gobbetti","year":"1998","unstructured":"Gobbetti, M. The sourdough microflora: Interactions of lactic acid bacteria and yeasts. Trends Food Sci. Technol. 9, 267\u2013274. https:\/\/doi.org\/10.1016\/S0924-2244(98)00053-3 (1998).","journal-title":"Trends Food Sci. Technol."},{"key":"59869_CR29","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.copbio.2016.11.010","volume":"44","author":"ML Marco","year":"2017","unstructured":"Marco, M. L. et al. Health benefits of fermented foods: Microbiota and beyond. Curr. Opin. Biotechnol. 44, 94\u2013102 (2017).","journal-title":"Curr. Opin. Biotechnol."},{"key":"59869_CR30","doi-asserted-by":"publisher","first-page":"2610","DOI":"10.1038\/s41467-020-16438-8","volume":"11","author":"E Pasolli","year":"2020","unstructured":"Pasolli, E. et al. Large-scale genome-wide analysis links lactic acid bacteria from food with the gut microbiome. Nat. Commun. 11, 2610 (2020).","journal-title":"Nat. Commun."},{"key":"59869_CR31","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1093\/genetics\/134.3.717","volume":"134","author":"WA Fonzi","year":"1993","unstructured":"Fonzi, W. A. & Irwin, M. Y. Isogenic strain construction and gene mapping in Candida albicans. Genetics 134, 717\u2013728 (1993).","journal-title":"Genetics"},{"key":"59869_CR32","unstructured":"Oerlemans, E. Topical Lactobacillus Applications for Modulation of the Vaginal and Skin Microbiota: Thesis (2019). https:\/\/hdl.handle.net\/10067\/1583510151162165141."},{"key":"59869_CR33","doi-asserted-by":"publisher","first-page":"879","DOI":"10.3390\/diagnostics10110879","volume":"10","author":"EFM Oerlemans","year":"2020","unstructured":"Oerlemans, E. F. M. et al. The dwindling microbiota of aerobic vaginitis, an inflammatory state enriched in pathobionts with limited TLR stimulation. Diagnostics 10, 879 (2020).","journal-title":"Diagnostics"},{"key":"59869_CR34","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1099\/ijsem.0.005976","volume":"73","author":"T Eilers","year":"2023","unstructured":"Eilers, T., Dillen, J., de Vliet, N., Wittouck, S. & Lebeer, S. Lactiplantibacillus carotarum AMBF275T sp. nov. isolated from carrot juice fermentation. Int. J. Syst. Evol. Microbiol. 73, 7 (2023).","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"59869_CR35","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1128\/AEM.00134-18","volume":"84","author":"S Wuyts","year":"2018","unstructured":"Wuyts, S. et al. Carrot juice fermentations as man-made microbial ecosystems dominated by lactic acid bacteria. Appl. Environ. Microbiol. 84, 12 (2018).","journal-title":"Appl. Environ. Microbiol."},{"key":"59869_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-019-44579-4","volume":"9","author":"SJ Jang","year":"2019","unstructured":"Jang, S. J., Lee, K., Kwon, B., You, H. J. & Ko, G. P. Vaginal lactobacilli inhibit growth and hyphae formation of Candida albicans. Sci. Rep. 9, 1\u20139 (2019).","journal-title":"Sci. Rep."},{"key":"59869_CR37","doi-asserted-by":"publisher","first-page":"3214","DOI":"10.1128\/aem.55.12.3214-3220.1989","volume":"55","author":"E Postma","year":"1989","unstructured":"Postma, E., Kuiper, A., Tomasouw, W. F., Scheffers, W. A. & van Dijken, J. P. Competition for glucose between the yeasts Saccharomyces cerevisiae and Candida utilis. Appl. Environ. Microbiol. 55, 3214\u20133220 (1989).","journal-title":"Appl. Environ. Microbiol."},{"key":"59869_CR38","first-page":"428","volume":"1","author":"D Pacha-Herrera","year":"2022","unstructured":"Pacha-Herrera, D. et al. Clustering analysis of the multi-microbial consortium by Lactobacillus species against vaginal dysbiosis among ecuadorian women. Front. Cell Infect. Microbiol. 1, 428 (2022).","journal-title":"Front. Cell Infect. Microbiol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-59869-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-59869-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-59869-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T18:15:57Z","timestamp":1713896157000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-59869-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,23]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["59869"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-59869-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,23]]},"assertion":[{"value":"13 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This work was conducted in the context of a research agreement between the University of Antwerp and Lesaffre International supported by Lesaffre International. NB, LJ, MB and BR are employees of Lesaffre. SL is a voluntary academic board member of ISAPP (International Scientific Association of Probiotics and Prebiotics, www.isappscience.org)\u00a0and cofounder of YUN (yun.be). The latter two organizations were not involved in this study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"9365"}}