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Bovay, Jr. Foundation Endowment to Support Geriatric Research & Education"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The present study examined the role of age and sex in the outcomes of non-surgical periodontal therapy (NSPT). De-identified demographic and periodontal characteristics of patients who presented for baseline periodontal evaluation, NSPT, and periodontal re-evaluation were abstracted from electronic health records. Independent associations of age and sex with severe periodontitis defined as \u2265\u20095\u00a0mm clinical attachment loss (CAL) and \u2265\u20096\u00a0mm probing depth (PD) were determined using multinomial logistic regression. The null hypothesis was rejected at \u03b1\u2009&lt;\u20090.05. A total of 2866 eligible subjects were included in the analysis. Significantly lower odds of CAL\u2009\u2264\u20094\u00a0mm than CAL\u2009\u2265\u20095\u00a0mm (\n                    <jats:italic>reference<\/jats:italic>\n                    ) were observed in adults aged 35\u201364 (odds ratio, OR, 0.19; 95% confidence interval, CI 0.13, 0.29) and\u2009\u2265\u200965\u00a0years (OR 0.13; 95% CI 0.07, 0.25) compared to those aged 18\u201334\u00a0years. Odds of PD\u2009&lt;\u20094\u00a0mm versus PD\u2009\u2265\u20096\u00a0mm (\n                    <jats:italic>reference<\/jats:italic>\n                    ) were lower in adults aged 35\u201364\u00a0years than those aged 18\u201334\u00a0years (OR 0.71; 95% CI 0.55, 0.90) and higher in females compared to males (OR 1.67; 95% CI 1.14, 2.44). These results suggest more compromised post-NSPT outcomes in older adults and males compared to the respective populations and highlight the need for personalized therapeutic strategies in these populations.\n                  <\/jats:p>","DOI":"10.1038\/s41598-024-60094-7","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T07:01:44Z","timestamp":1714028504000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A retrospective analysis of the role of age and sex in outcomes of non-surgical periodontal therapy at a single academic dental center"],"prefix":"10.1038","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0800-2778","authenticated-orcid":false,"given":"Nikola","family":"Angelov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2821-7063","authenticated-orcid":false,"given":"Nikolaos","family":"Soldatos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1954-5900","authenticated-orcid":false,"given":"Effie","family":"Ioannidou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2107-7838","authenticated-orcid":false,"given":"Tonia C.","family":"Carter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7545-622X","authenticated-orcid":false,"given":"Neel","family":"Shimpi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9939-5553","authenticated-orcid":false,"given":"Joseph","family":"Applegate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8228-5796","authenticated-orcid":false,"given":"Krishna Kumar","family":"Kookal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5440-6036","authenticated-orcid":false,"given":"Karo","family":"Parsegian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,25]]},"reference":[{"issue":"86","key":"60094_CR1","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1111\/prd.12362","volume":"2000","author":"L Abusleme","year":"2021","unstructured":"Abusleme, L., Hoare, A., Hong, B. 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The funders of the study had no role in the study design, data collection, data analysis, data interpretation, or writing of the manuscript. The views expressed in this manuscript are those of the authors and do not necessarily reflect the official policy of the UTHealth Houston\u00a0School of Dentistry.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"9504"}}