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Surprisingly, in the presence of sulfite, used as a preservative, wine strains produce more H\n                    <jats:sub>2<\/jats:sub>\n                    S than wild (oak) or wine velum (\n                    <jats:italic>flor<\/jats:italic>\n                    ) isolates during fermentation. Since copper resistance caused by the amplification of the sulfur rich protein Cup1p is a specific adaptation trait of wine strains, we analyzed the link between copper resistance mechanism, sulfur metabolism and H\n                    <jats:sub>2<\/jats:sub>\n                    S production. We show that a higher content of copper in the must increases the production of H\n                    <jats:sub>2<\/jats:sub>\n                    S, and that SO\n                    <jats:sub>2<\/jats:sub>\n                    increases the resistance to copper. Using a set of 51 strains we observed a positive and then negative relation between the number of copies of\n                    <jats:italic>CUP1<\/jats:italic>\n                    and H\n                    <jats:sub>2<\/jats:sub>\n                    S production during fermentation. This complex pattern could be mimicked using a multicopy plasmid carrying\n                    <jats:italic>CUP1<\/jats:italic>\n                    , confirming the relation between copper resistance and H\n                    <jats:sub>2<\/jats:sub>\n                    S production. The massive use of copper for vine sanitary management has led to the selection of resistant strains at the cost of a metabolic tradeoff: the overproduction of H\n                    <jats:sub>2<\/jats:sub>\n                    S, resulting in a decrease in wine quality.\n                  <\/jats:p>","DOI":"10.1038\/s41598-024-60335-9","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T10:02:42Z","timestamp":1714644162000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Copper-based grape pest management has impacted wine aroma"],"prefix":"10.1038","volume":"14","author":[{"given":"Irene","family":"De Guidi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Galeote","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Blondin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Legras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,2]]},"reference":[{"issue":"48","key":"60335_CR1","doi-asserted-by":"publisher","first-page":"E10309","DOI":"10.1073\/PNAS.1714728114\/SUPPL_FILE\/PNAS.1714728114.SD03.XLSB","volume":"114","author":"P McGovern","year":"2017","unstructured":"McGovern, P. et al. 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