{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T09:27:28Z","timestamp":1758274048159},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to investigate the value of diffusion-weighted imaging (DWI) as a potential non-gadolinium alternative for promptly assessing the hyperacute outcome of magnetic resonance-guided focused ultrasound (MRgFUS) treatment for uterine fibroids. In this retrospective study we included 65 uterine fibroids from 44 women, who underwent axial DWI (b-value: 800\u00a0s\/mm<jats:sup>2<\/jats:sup>) and contrast-enhanced (CE) MR within 15\u00a0min post-ablation. Two blinded observers independently reviewed the DWI findings of ablated necrotic lesions and measured their volumes on DWI and CE images. The post-ablation DWI images revealed clear depiction of ablative necrotic lesions in all fibroids, which were classified into two types: the bull\u2019s eye sign (type 1) and the bright patch sign (type 2). The inter-observer intraclass correlation coefficient for classifying DWI signal types was 0.804 (<jats:italic>p<\/jats:italic> &lt; 0.001). Volumetric analysis of ablated necrosis using DWI and CE T1-weighted imaging showed no significant variance, nor did the non-perfused volume ratios (all <jats:italic>p<\/jats:italic> &gt; 0.05). Bland\u2013Altman analysis revealed a mean difference of 2.38% and 1.71% in non-perfused volume ratios between DWI and CE, with 95% limits of agreement from \u2212 19.06 to 23.82% and \u2212 18.40 to 21.82%, respectively. The findings of this study support the potential of DWI as a viable non-gadolinium alternative for evaluating the hyperacute outcomes of MRgFUS ablation in uterine fibroids. <\/jats:p>","DOI":"10.1038\/s41598-024-60693-4","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T19:02:13Z","timestamp":1714417333000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Diffusion-weighted imaging as a potential non-gadolinium alternative for immediate assessing the hyperacute outcome of MRgFUS ablation for uterine fibroids"],"prefix":"10.1038","volume":"14","author":[{"given":"Yaoqu","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shouguo","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinghua","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuochao","family":"Pang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shihua","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,4,29]]},"reference":[{"key":"60693_CR1","doi-asserted-by":"publisher","DOI":"10.1080\/02656736.2023.2219436","author":"J Kociuba","year":"2023","unstructured":"Kociuba, J. et al. Occurrence of adverse events after magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) therapy in symptomatic uterine fibroids\u2014a retrospective case-control study. Int. J. Hyperth. https:\/\/doi.org\/10.1080\/02656736.2023.2219436 (2023).","journal-title":"Int. J. Hyperth."},{"key":"60693_CR2","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1148\/radiol.2016141693","volume":"280","author":"JE Silberzweig","year":"2016","unstructured":"Silberzweig, J. E., Powell, D. K., Matsumoto, A. H. & Spies, J. B. Management of uterine fibroids: A focus on uterine-sparing interventional techniques. Radiology 280, 675\u2013692 (2016).","journal-title":"Radiology"},{"key":"60693_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2019.108700","author":"IM Verpalen","year":"2019","unstructured":"Verpalen, I. M. et al. Magnetic resonance-high intensity focused ultrasound (MR-HIFU) therapy of symptomatic uterine fibroids with unrestrictive treatment protocols: A systematic review and meta-analysis. Eur. J. Radiol. https:\/\/doi.org\/10.1016\/j.ejrad.2019.108700 (2019).","journal-title":"Eur. J. Radiol."},{"key":"60693_CR4","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1007\/s00330-014-3538-6","volume":"25","author":"I Mindjuk","year":"2015","unstructured":"Mindjuk, I., Trumm, C. G., Herzog, P., Stahl, R. & Matzko, M. MRI predictors of clinical success in MR-guided focused ultrasound (MRgFUS) treatments of uterine fibroids: Results from a single centre. Eur. Radiol. 25, 1317\u20131328 (2015).","journal-title":"Eur. Radiol."},{"key":"60693_CR5","doi-asserted-by":"publisher","first-page":"7360","DOI":"10.1007\/s00330-023-09984-4","volume":"33","author":"RR Bitton","year":"2023","unstructured":"Bitton, R. R. et al. What predicts durable symptom relief of uterine fibroids treated with MRI-guided focused ultrasound? A multicenter trial in 8 academic centers. Eur. Radiol. 33, 7360\u20137370 (2023).","journal-title":"Eur. Radiol."},{"key":"60693_CR6","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1148\/radiol.2271020395","volume":"226","author":"CM Tempany","year":"2003","unstructured":"Tempany, C. M. et al. MR imaging-guided focused ultrasound surgery of uterine leiomyomas: A feasibility study. Radiology 226, 897\u2013905 (2003).","journal-title":"Radiology"},{"key":"60693_CR7","doi-asserted-by":"publisher","first-page":"4178","DOI":"10.1007\/s00330-022-09294-1","volume":"33","author":"DJ Slotman","year":"2023","unstructured":"Slotman, D. J. et al. Diffusion-weighted MRI with deep learning for visualizing treatment results of MR-guided HIFU ablation of uterine fibroids. Eur. Radiol. 33, 4178\u20134188 (2023).","journal-title":"Eur. Radiol."},{"key":"60693_CR8","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1177\/0284185120920801","volume":"62","author":"MA Erdo\u011fan","year":"2021","unstructured":"Erdo\u011fan, M. A., Apaydin, M., Armagan, G. & Taskiran, D. Evaluation of toxicity of gadolinium-based contrast agents on neuronal cells. Acta. Radiol. 62, 206\u2013214 (2021).","journal-title":"Acta. Radiol."},{"key":"60693_CR9","doi-asserted-by":"publisher","DOI":"10.1186\/2050-5736-1-8","author":"NM Hijnen","year":"2013","unstructured":"Hijnen, N. M. et al. The magnetic susceptibility effect of gadolinium-based contrast agents on PRFS-based MR thermometry during thermal interventions. J. Ther. Ultrasound. https:\/\/doi.org\/10.1186\/2050-5736-1-8 (2013).","journal-title":"J. Ther. Ultrasound."},{"key":"60693_CR10","doi-asserted-by":"publisher","DOI":"10.1186\/s41747-018-0041-x","author":"SL Giles","year":"2018","unstructured":"Giles, S. L. et al. Value of diffusiond -weighted imaging for monitoring tissue change during magnetic resonance-guided high-intensity focused ultrasound therapy in bone applications: An ex-vivo study. Eur. Radiol. Exp. https:\/\/doi.org\/10.1186\/s41747-018-0041-x (2018).","journal-title":"Eur. Radiol. Exp."},{"key":"60693_CR11","doi-asserted-by":"publisher","first-page":"2145","DOI":"10.1002\/mrm.28537","volume":"85","author":"SP Allen","year":"2021","unstructured":"Allen, S. P. et al. A preclinical study of diffusion-weighted MRI contrast as an early indicator of thermal ablation. Magn. Reson. Med. 85, 2145\u20132159 (2021).","journal-title":"Magn. Reson. Med."},{"key":"60693_CR12","doi-asserted-by":"publisher","first-page":"5130","DOI":"10.1118\/1.4928155","volume":"42","author":"JC Plata","year":"2015","unstructured":"Plata, J. C. et al. A feasibility study on monitoring the evolution of apparent diffusion coefficient decrease during thermal ablation. Med. Phys. 42, 5130\u20135137 (2015).","journal-title":"Med. Phys."},{"key":"60693_CR13","doi-asserted-by":"publisher","first-page":"2118","DOI":"10.1007\/s00330-014-3274-y","volume":"24","author":"ME Ikink","year":"2014","unstructured":"Ikink, M. E. et al. Diffusion-weighted magnetic resonance imaging using different b-value combinations for the evaluation of treatment results after volumetric MR-guided high-intensity focused ultrasound ablation of uterine fibroids. Eur. Radiol. 24, 2118\u20132127 (2014).","journal-title":"Eur. Radiol."},{"key":"60693_CR14","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1002\/mrm.21589","volume":"59","author":"J Chen","year":"2008","unstructured":"Chen, J. et al. Monitoring prostate thermal therapy with diffusion-weighted MRI. Magn. Reson. Med. 59, 1365\u20131372 (2008).","journal-title":"Magn. Reson. Med."},{"key":"60693_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2019.108670","author":"D Liao","year":"2020","unstructured":"Liao, D., Xiao, Z., Lv, F., Chen, J. & Qiu, L. Non-contrast enhanced MRI for assessment of uterine fibroids\u2019 early response to ultrasound-guided high-intensity focused ultrasound thermal ablation. Eur. J. Radiol. https:\/\/doi.org\/10.1016\/j.ejrad.2019.108670 (2020).","journal-title":"Eur. J. Radiol."},{"key":"60693_CR16","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1002\/jmri.21688","volume":"29","author":"MC Pilatou","year":"2009","unstructured":"Pilatou, M. C. et al. MRI-based thermal dosimetry and diffusion-weighted imaging of MRI-guided focused ultrasound thermal ablation of uterine fibroids. J. Magn. Reson. Imaging. 29, 404\u2013411 (2009).","journal-title":"J. Magn. Reson. Imaging"},{"key":"60693_CR17","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/S0140-6736(86)90837-8","volume":"1","author":"JM Bland","year":"1986","unstructured":"Bland, J. M. & Altman, D. G. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1, 307\u2013310 (1986).","journal-title":"Lancet"},{"key":"60693_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2021.109557","author":"M Chen","year":"2021","unstructured":"Chen, M. et al. Comparison of reduced field-of-view diffusion-weighted imaging (DWI) and conventional DWI techniques in the assessment of cervical carcinoma at 3.0T: Image quality and FIGO staging. Eur. J. Radiol. https:\/\/doi.org\/10.1016\/j.ejrad.2021.109557 (2021).","journal-title":"Eur. J. Radiol."},{"key":"60693_CR19","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1067\/j.cpradiol.2017.03.004","volume":"47","author":"AB Rosenkrantz","year":"2018","unstructured":"Rosenkrantz, A. B. & Taneja, S. S. Use of reduced field-of-view acquisition to improve prostate cancer visualization on diffusion-weighted magnetic resonance imaging in the presence of hip implants: Report of 2 Cases. Curr. Probl. Diagn. Radiol. 47, 125\u2013127 (2018).","journal-title":"Curr. Probl. Diagn. Radiol."},{"key":"60693_CR20","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20210692","author":"M Takeuchi","year":"2022","unstructured":"Takeuchi, M., Matsuzaki, K. & Harada, M. The feasibility of reduced field-of-view diffusion-weighted imaging in evaluating bladder invasion of uterine cervical cancer. Br. J. Radiol. https:\/\/doi.org\/10.1259\/bjr.20210692 (2022).","journal-title":"Br. J. Radiol."},{"key":"60693_CR21","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.mri.2014.08.040","volume":"33","author":"N Korn","year":"2015","unstructured":"Korn, N. et al. Reduced-FOV excitation decreases susceptibility artifact in diffusion-weighted MRI with endorectal coil for prostate cancer detection. Magn. Reson. Imaging 33, 56\u201362 (2015).","journal-title":"Magn. Reson. Imaging"},{"key":"60693_CR22","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1016\/j.jvir.2012.02.015","volume":"23","author":"AM Venkatesan","year":"2012","unstructured":"Venkatesan, A. M. et al. Magnetic resonance imaging-guided volumetric ablation of symptomatic leiomyomata: Correlation of imaging with histology. J. Vasc. Interv. Radiol. 23, 786-794.e4 (2012).","journal-title":"J. Vasc. Interv. Radiol."},{"key":"60693_CR23","doi-asserted-by":"publisher","first-page":"2234666","DOI":"10.1080\/02656736.2023.2234666","volume":"40","author":"A Viitala","year":"2023","unstructured":"Viitala, A. et al. Histological findings in resected leiomyomas following MR-HIFU treatment, single-institution data from seven patients with unfavorable focal therapy. Int. J. Hyperth. 40, 2234666 (2023).","journal-title":"Int. J. Hyperth."},{"key":"60693_CR24","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1002\/jmri.21677","volume":"29","author":"MA Jacobs","year":"2009","unstructured":"Jacobs, M. A. et al. Proton, diffusion-weighted imaging, and sodium (23Na) MRI of uterine leiomyomata after MR-guided high-intensity focused ultrasound: A preliminary study. J. Magn. Reson. Imaging 29, 649\u2013656 (2009).","journal-title":"J. Magn. Reson. Imaging"},{"key":"60693_CR25","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s00404-007-0435-0","volume":"277","author":"JH Fruehauf","year":"2008","unstructured":"Fruehauf, J. H. et al. High-intensity focused ultrasound for the targeted destruction of uterine tissues: Experiences from a pilot study using a mobile HIFU unit. Arch. Gynecol. Obstet. 277, 143\u2013150 (2008).","journal-title":"Arch. Gynecol. Obstet."},{"key":"60693_CR26","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1178649","author":"Y Jiang","year":"2023","unstructured":"Jiang, Y. et al. Intravoxel incoherent motion diffusion-weighted MRI for predicting the efficacy of high-intensity focused ultrasound ablation for uterine fibroids. Front. Oncol. https:\/\/doi.org\/10.3389\/fonc.2023.1178649 (2023).","journal-title":"Front. Oncol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-60693-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-60693-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-60693-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T19:07:35Z","timestamp":1714417655000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-60693-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,29]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["60693"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-60693-4","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,29]]},"assertion":[{"value":"18 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"9857"}}