{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T21:31:56Z","timestamp":1768339916719,"version":"3.49.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T00:00:00Z","timestamp":1715126400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T00:00:00Z","timestamp":1715126400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2021R1F1A1048198"],"award-info":[{"award-number":["2021R1F1A1048198"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chung-Ang University Research Grants","award":["2023"],"award-info":[{"award-number":["2023"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To investigate the influence of preoperative smoking history on the survival outcomes and complications in a cohort from a large multicenter database. Many patients who undergo radical cystectomy (RC) have a history of smoking; however, the direct association between preoperative smoking history and survival outcomes and complications in patients with muscle-invasive bladder cancer (MIBC) who undergo robot-assisted radical cystectomy (RARC) remains unexplored. We conducted a retrospective analysis using data from 749 patients in the Korean Robot-Assisted Radical Cystectomy Study Group (KORARC) database, with an average follow-up duration of 30.8\u00a0months. The cohort was divided into two groups: smokers (n\u2009=\u2009351) and non-smokers (n\u2009=\u2009398). Propensity score matching was employed to address differences in sample size and baseline demographics between the two groups (n\u2009=\u2009274, each). Comparative analyses included assessments of oncological outcomes and complications. After matching, smoking did not significantly affect the overall complication rate (<jats:italic>p<\/jats:italic>\u2009=\u20090.121). Preoperative smoking did not significantly increase the occurrence of complications based on complication type (p\u2009=\u20090.322), nor did it increase the readmission rate (p\u2009=\u20090.076). There were no perioperative death in either group. Furthermore, preoperative smoking history showed no significant impact on overall survival (OS) [hazard ratio (HR)\u2009=\u20090.87, interquartile range (IQR): 0.54\u20131.42; <jats:italic>p<\/jats:italic>\u2009=\u20090.589] and recurrence-free survival (RFS) (HR\u2009=\u20091.12, IQR: 0.83\u20131.53; <jats:italic>p<\/jats:italic>\u2009=\u20090.458) following RARC for MIBC. The extent of preoperative smoking (\u2264\u200910, 10\u201330, and\u2009\u2265\u200930 pack-years) had no significant influence on OS and RFS in any of the categories (all <jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). Preoperative smoking history did not significantly affect OS, RFS, or complications in patients with MIBC undergoing RARC.<\/jats:p>","DOI":"10.1038\/s41598-024-61005-6","type":"journal-article","created":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T09:02:19Z","timestamp":1715158939000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Preoperative smoking and robot-assisted radical cystectomy outcomes &amp; complications in multicenter KORARC database"],"prefix":"10.1038","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5978-8179","authenticated-orcid":false,"given":"Joongwon","family":"Choi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3246-5246","authenticated-orcid":false,"given":"Jooyoung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3046-7998","authenticated-orcid":false,"given":"Yu Been","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5399-2184","authenticated-orcid":false,"given":"Byong 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Kil","family":"Nam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8566-3353","authenticated-orcid":false,"given":"Wansuk","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6775-1157","authenticated-orcid":false,"given":"Ji Youl","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1952-4010","authenticated-orcid":false,"given":"Sung Hoo","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8588-7584","authenticated-orcid":false,"given":"Koon Ho","family":"Rha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2527-4046","authenticated-orcid":false,"given":"Woong Kyu","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2246-8838","authenticated-orcid":false,"given":"Won Sik","family":"Ham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1112-7077","authenticated-orcid":false,"given":"Sung Gu","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1524-5233","authenticated-orcid":false,"given":"Seok 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Refraining from smoking for 15 years or more reduced the risk of tumor recurrence in non-muscle invasive bladder cancer patients. Ann. Surg. Oncol. 23, 1752\u20131759 (2016).","journal-title":"Ann. Surg. Oncol."},{"key":"61005_CR7","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1016\/j.euf.2022.02.005","volume":"8","author":"SV Lauridsen","year":"2022","unstructured":"Lauridsen, S. V. et al. Effect of a smoking and alcohol cessation intervention initiated shortly before radical cystectomy\u2014The STOP-OP Study: A randomised clinical trial. Eur. Urol. Focus 8, 1650\u20131658 (2022).","journal-title":"Eur. Urol. Focus"},{"key":"61005_CR8","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.urolonc.2019.10.011","volume":"38","author":"SW Reese","year":"2020","unstructured":"Reese, S. W. et al. Risk factors and reasons for reoperation after radical cystectomy. Urol. Oncol. 38, 269\u2013277 (2020).","journal-title":"Urol. 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