{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T06:49:05Z","timestamp":1787813345507,"version":"build-2784847793"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In transcatheter aortic valve implantation (TAVI), final device position may be affected by device interaction with the whole aortic landing zone (LZ) extending to ascending aorta. We investigated the impact of aortic LZ curvature and angulation on TAVI implantation depth, comparing short-frame balloon-expanding (BE) and long-frame self-expanding (SE) devices. Patients (n\u2009=\u2009202) treated with BE or SE devices were matched based on one-to-one propensity score. Primary endpoint was the mismatch between the intended (H<jats:sub>Pre<\/jats:sub>) and the final (H<jats:sub>Post<\/jats:sub>) implantation depth. LZ curvature and angulation were calculated based on the aortic centerline trajectory available from pre-TAVI computed tomography. Total LZ curvature (<jats:inline-formula><jats:alternatives><jats:tex-math>$${k}_{LZ,tot}$$<\/jats:tex-math><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                  <mml:msub>\n                    <mml:mi>k<\/mml:mi>\n                    <mml:mrow>\n                      <mml:mi>L<\/mml:mi>\n                      <mml:mi>Z<\/mml:mi>\n                      <mml:mo>,<\/mml:mo>\n                      <mml:mi>t<\/mml:mi>\n                      <mml:mi>o<\/mml:mi>\n                      <mml:mi>t<\/mml:mi>\n                    <\/mml:mrow>\n                  <\/mml:msub>\n                <\/mml:math><\/jats:alternatives><\/jats:inline-formula>) and LZ angulation distal to aortic annulus (<jats:inline-formula><jats:alternatives><jats:tex-math>$${\\alpha }_{LZ,Distal}$$<\/jats:tex-math><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                  <mml:msub>\n                    <mml:mi>\u03b1<\/mml:mi>\n                    <mml:mrow>\n                      <mml:mi>L<\/mml:mi>\n                      <mml:mi>Z<\/mml:mi>\n                      <mml:mo>,<\/mml:mo>\n                      <mml:mi>D<\/mml:mi>\n                      <mml:mi>i<\/mml:mi>\n                      <mml:mi>s<\/mml:mi>\n                      <mml:mi>t<\/mml:mi>\n                      <mml:mi>a<\/mml:mi>\n                      <mml:mi>l<\/mml:mi>\n                    <\/mml:mrow>\n                  <\/mml:msub>\n                <\/mml:math><\/jats:alternatives><\/jats:inline-formula>) were greater in the SE compared to the BE group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 for both). In the BE group, H<jats:sub>Post<\/jats:sub> was significantly higher than H<jats:sub>Pre<\/jats:sub> at both cusps (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). In the SE group, H<jats:sub>Post<\/jats:sub> was significantly deeper than H<jats:sub>Pre<\/jats:sub> only at the left coronary cusp (<jats:italic>P<\/jats:italic>\u2009=\u20090.013). At multivariate analysis, <jats:inline-formula><jats:alternatives><jats:tex-math>$${\\alpha }_{LZ,Distal}$$<\/jats:tex-math><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                  <mml:msub>\n                    <mml:mi>\u03b1<\/mml:mi>\n                    <mml:mrow>\n                      <mml:mi>L<\/mml:mi>\n                      <mml:mi>Z<\/mml:mi>\n                      <mml:mo>,<\/mml:mo>\n                      <mml:mi>D<\/mml:mi>\n                      <mml:mi>i<\/mml:mi>\n                      <mml:mi>s<\/mml:mi>\n                      <mml:mi>t<\/mml:mi>\n                      <mml:mi>a<\/mml:mi>\n                      <mml:mi>l<\/mml:mi>\n                    <\/mml:mrow>\n                  <\/mml:msub>\n                <\/mml:math><\/jats:alternatives><\/jats:inline-formula> was the only independent predictor (OR\u2009=\u20091.11, <jats:italic>P<\/jats:italic>\u2009=\u20090.002) of deeper final implantation depth with a cut-off value of 17.8\u00b0. Aortic LZ curvature and angulation significantly affected final TAVI implantation depth, especially in high stent-frame SE devices reporting, upon complete release, deeper implantation depth with respect to the intended one.<\/jats:p>","DOI":"10.1038\/s41598-024-61084-5","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T17:01:55Z","timestamp":1715014915000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Angulation and curvature of aortic landing zone affect implantation depth in transcatheter aortic valve implantation"],"prefix":"10.1038","volume":"14","author":[{"given":"Riccardo","family":"Gorla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar A.","family":"Oliva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Arzuffi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Milani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Saitta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Squillace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Poletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Tusa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiliano","family":"Votta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nedy","family":"Brambilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Testa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bedogni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Sturla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,6]]},"reference":[{"key":"61084_CR1","doi-asserted-by":"publisher","first-page":"2477","DOI":"10.1016\/s0140-6736(15)60308-7","volume":"385","author":"MJ Mack","year":"2015","unstructured":"Mack, M. 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All the remaining authors declare no financial and non-financial competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"10409"}}