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Clinical symptoms of focal seizures, as well as findings at the onset or end of a focal to bilateral tonic\u2013clonic seizure (FBTCS), are highly informative for lateralization. This study aimed to investigate the relationship of asymmetric last clonic jerk in patients with temporal or extratemporal lobe epilepsy with pathologies, localization, lateralization, or other semiological findings detected in neuroimaging or neuro psychometric tests and its positive predictive value for the detection of hemisphere lateralization based on seizure onset ictal EEG activation. 44 patients with asymmetric last clonic jerks\u00a0(aLCJ) who were followed up in our VEM unit were randomized 1:1 with epilepsy patients without. In patients with ipsilateral automatism and contralateral posture or gustatory and olfactory hallucinations aLCJ was less or absent. In patients with unilateral tonic activity, aLCJ was more common. The positive predictive value of aLCJ for ictal EEG activation lateralization was 86.36%. In conclusion, asymmetric last clonic beat is valuable for lateralization of FBTCS and should be considered. Its presence strongly and reliably lateralizes to the side of seizure onset.<\/jats:p>","DOI":"10.1038\/s41598-024-61401-y","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T11:02:01Z","timestamp":1716289321000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Lateralizing value and clinicoradiological features of asymmetric last clonic jerks in temporal and extratemporal epilepsy"],"prefix":"10.1038","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5945-2317","authenticated-orcid":false,"given":"Furkan","family":"Saridas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2052-6335","authenticated-orcid":false,"given":"Gizem","family":"Mesut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0342-5939","authenticated-orcid":false,"given":"Yasemin","family":"Dinc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6739-8605","authenticated-orcid":false,"given":"Aylin","family":"Bican Demir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9435-6037","authenticated-orcid":false,"given":"Ibrahim","family":"Bora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,21]]},"reference":[{"issue":"12","key":"61401_CR1","doi-asserted-by":"publisher","first-page":"2519","DOI":"10.1212\/WNL.43.12.2519","volume":"43","author":"MW Chee","year":"1993","unstructured":"Chee, M. 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