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Nevertheless, the relationship between different ABO blood groups and myocardial injury after non-cardiac surgery (MINS) is poorly understood. This study verified whether ABO blood group is a potential MINS influencing factor. This retrospective cohort study included 1201 patients who underwent elective non-cardiac surgery and a mandatory troponin test on postoperative days 1 and 2 from 2019 to 2020 at a university-affiliated tertiary hospital. The primary outcome was associations between ABO blood groups and MINS, assessed using univariate and multivariate logistic-regression analyses. Path analysis was used to investigate direct and indirect effects between blood group and MINS. MINS incidence (102\/1201, 8.5%) was higher in blood-type B patients than in non-B patients [blood-type B: 44\/400 (11.0%) vs. non-B: 58\/801 (7.2%); adjusted odds ratio\u2009=\u20091.57 (1.03\u20132.38); <jats:italic>p<\/jats:italic>\u2009=\u20090.036]. In the confounding factor model, preoperative hypertension and coronary artery disease medical history were associated with MINS risk [adjusted odds ratio: 2.00 (1.30\u20133.06), <jats:italic>p<\/jats:italic>\u2009=\u20090.002; 2.81 (1.71\u20134.61), <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, respectively]. Path analysis did not uncover any mediating role for hypertension, diabetes, or coronary artery disease between blood type and MINS. Therefore, blood-type B is associated with higher MINS risk; potential mediators of this association need to be investigated.<\/jats:p>","DOI":"10.1038\/s41598-024-61546-w","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T09:02:34Z","timestamp":1718701354000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association between blood groups and myocardial injury after non-cardiac surgery: a retrospective cohort study"],"prefix":"10.1038","volume":"14","author":[{"given":"Jinze","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longyun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengze","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,18]]},"reference":[{"key":"61546_CR1","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1097\/01.moh.0000153000.09585.79","volume":"12","author":"N Mohandas","year":"2005","unstructured":"Mohandas, N. & Narla, A. 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