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The aim is to evaluate the effects of a restricted diet on clinical\/laboratory inflammation and metabolic profile, reactive oxygen species (ROS), and body composition in patients with COVID-19 comorbid with NCDs. We conducted a 6-week open, pilot prospective controlled clinical trial. The study included 70 adult patients with COVID-19 comorbid with type 2 diabetes (T2D), hypertension, or nonalcoholic steatohepatitis (NASH). Interventions: a restricted diet including calorie restriction, hot water drinking, walking, and sexual self-restraint. Primary endpoints: COVID-19 diagnosis by detecting SARS-CoV-2 genome by RT-PCR; weight loss in Main group; body temperature; C-reactive protein. Secondary endpoints: the number of white blood cells; erythrocyte sedimentation rate; adverse effects during treatment; fasting blood glucose, glycosylated hemoglobin A1c (HbA1c), systolic\/diastolic blood pressure (BP); blood lipids; ALT\/AST, chest CT-scan. In Main group, patients with overweight lost weight from baseline (\u2212\u200912.4%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001); 2.9% in Main group and 7.2% in Controls were positive for COVID-19 (RR: 0.41, CI: 0.04\u20134.31; <jats:italic>P<\/jats:italic>\u2009=\u20090.22) on the 14th day of treatment. Body temperature and C-reactive protein decreased significantly in Main group compared to Controls on day 14th of treatment (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.025). Systolic\/diastolic BP normalized (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.025), glucose\/lipids metabolism (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.025); ALT\/AST normalized (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.025), platelets increased from baseline (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.025), chest CT (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.025) in Main group at 14\u00a0day of treatment. The previous antidiabetic, antihypertensive, anti-inflammatory, hepatoprotective, and other symptomatic medications were adequately decreased to completely stop during the weight loss treatment. Thus, the fast weight loss treatment may be beneficial for the COVID-19 patients with comorbid T2D, hypertension, and NASH over traditional medical treatment because, it improved clinical and laboratory\/instrumental data on inflammation; glucose\/lipid metabolism, systolic\/diastolic BPs, and NASH biochemical outcomes, reactive oxygen species; and allowed patients to stop taking medications.<\/jats:p><jats:p>Trial Registration: ClinicalTrials.gov NCT05635539 (02\/12\/2022): <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05635539?term=NCT05635539&amp;draw=2&amp;rank=1\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05635539?term=NCT05635539&amp;draw=2&amp;rank=1<\/jats:ext-link>.<\/jats:p>","DOI":"10.1038\/s41598-024-61703-1","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T07:02:21Z","timestamp":1715670141000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Weight loss treatment for COVID-19 in patients with NCDs: a pilot prospective clinical trial"],"prefix":"10.1038","volume":"14","clinical-trial-number":[{"clinical-trial-number":"nct05635539","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Kuat","family":"Oshakbayev","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aigul","family":"Durmanova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zulfiya","family":"Zhankalova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alisher","family":"Idrisov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulnara","family":"Bedelbayeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meruyert","family":"Gazaliyeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Altay","family":"Nabiyev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attila","family":"Tordai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bibazhar","family":"Dukenbayeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,5,14]]},"reference":[{"key":"61703_CR1","unstructured":"Federation, W. 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