{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T20:59:58Z","timestamp":1782421198673,"version":"3.54.5"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T00:00:00Z","timestamp":1715472000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T00:00:00Z","timestamp":1715472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Research on the relationships between oligoelements (OE) and the development of cancer or its prevention is a field that is gaining increasing relevance.\u00a0The aim was to evaluate OE and their interactions with oncology treatments (cytarabine or etoposide) to determine the effects of this combination on biogenic amines and oxidative stress biomarkers in the brain regions of young Wistar rats. Dopamine (DA), 5-Hydroxyindoleacetic acid (5-Hiaa), Glutathione (Gsh), Tiobarbituric acid reactive substances (TBARS) and Ca<jats:sup>+2<\/jats:sup>, Mg<jats:sup>+2<\/jats:sup> ATPase enzyme activity were measured in brain regions tissues using spectrophometric and fluorometric methods previously validated. The combination of oligoelements and cytarabine increased dopamine in the striatum but decreased it in cerebellum\/medulla-oblongata, whereas the combination of oligoelements and etoposide reduced lipid peroxidation. These results suggest that supplementation with oligoelements modifies the effects of cytarabine and etoposide by redox pathways, and may become promising therapeutic targets in patients with cancer.<\/jats:p>","DOI":"10.1038\/s41598-024-61766-0","type":"journal-article","created":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T05:01:43Z","timestamp":1715490103000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Intake of oligoelements with cytarabine or etoposide alters dopamine levels and oxidative damage in rat brain"],"prefix":"10.1038","volume":"14","author":[{"given":"David Calder\u00f3n","family":"Guzm\u00e1n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma Osnaya","family":"Brizuela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maribel Ort\u00edz","family":"Herrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1405-1728","authenticated-orcid":false,"given":"Hugo Ju\u00e1rez","family":"Olgu\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando Valenzuela","family":"Peraza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma Labra","family":"Ru\u00edz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo Barrag\u00e1n","family":"Mej\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,12]]},"reference":[{"key":"61766_CR1","doi-asserted-by":"publisher","first-page":"146","DOI":"10.15430\/JCP.2019.24.3.146","volume":"24","author":"A Yildiz","year":"2019","unstructured":"Yildiz, A., Kaya, Y. & Tanriverdi, O. Effect of the interaction between selenium and zinc on DNA repair in association with cancer prevention. J. Cancer Prev. 24, 146\u2013154 (2019).","journal-title":"J. Cancer Prev."},{"key":"61766_CR2","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab200","author":"QT Ostrom","year":"2021","unstructured":"Ostrom, Q. T., Cioffi, G., Waite, K., Kruchko, C. & Barnholtz-Sloan, J. S. CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2014\u20132018. Neuro Oncol. https:\/\/doi.org\/10.1093\/neuonc\/noab200 (2021).","journal-title":"Neuro Oncol."},{"key":"61766_CR3","first-page":"253","volume":"2","author":"BJ Bolwell","year":"1988","unstructured":"Bolwell, B. J., Cassileth, P. A. & Gale, R. P. High dose cytarabine: A review. Leukemia 2, 253\u2013260 (1988).","journal-title":"Leukemia"},{"key":"61766_CR4","doi-asserted-by":"publisher","first-page":"105106","DOI":"10.1016\/j.tiv.2021.105106","volume":"72","author":"A Mameri","year":"2021","unstructured":"Mameri, A., Bournine, L., Mouni, L., Bensalem, S. & Iguer-Ouada, M. Oxidative stress as an underlying mechanism of anticancer drugs cytotoxicity on human red blood cells\u2019 membrane. Toxicol. Vitro 72, 105106. https:\/\/doi.org\/10.1016\/j.tiv.2021.105106 (2021).","journal-title":"Toxicol. Vitro"},{"key":"61766_CR5","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1006\/excr.2000.5148","volume":"264","author":"NA Pham","year":"2001","unstructured":"Pham, N. A. & Hedley, D. W. Respiratory chain-generated oxidative stress following treatment of leukemic blasts with DNA-damaging agents. Exp. Cell Res. 264, 345\u2013352. https:\/\/doi.org\/10.1006\/excr.2000.5148 (2001).","journal-title":"Exp. Cell Res."},{"key":"61766_CR6","doi-asserted-by":"publisher","first-page":"557","DOI":"10.2147\/DDDT.S92687","volume":"10","author":"MA Papie\u017c","year":"2016","unstructured":"Papie\u017c, M. A. et al. Curcumin enhances the cytogenotoxic effect of etoposide in leukemia cells through induction of reactive oxygen species. Drug Des. Dev. Ther. 10, 557\u2013570. https:\/\/doi.org\/10.2147\/DDDT.S92687 (2016).","journal-title":"Drug Des. Dev. Ther."},{"key":"61766_CR7","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1007\/s11255-019-02113-5","volume":"51","author":"Y Yang","year":"2019","unstructured":"Yang, Y. et al. Intervention of mitochondrial activity attenuates cisplatin-induced acute kidney injury. Int. Urol. Nephrol. 51, 1207\u20131218. https:\/\/doi.org\/10.1007\/s11255-019-02113-5 (2019).","journal-title":"Int. Urol. Nephrol."},{"key":"61766_CR8","first-page":"124","volume":"48","author":"K Jakubczyk","year":"2020","unstructured":"Jakubczyk, K. et al. Reactive oxygen species-sources, functions, oxidative damage. Pol. Merkur Lekarski 48, 124\u2013127 (2020).","journal-title":"Pol. Merkur Lekarski"},{"key":"61766_CR9","doi-asserted-by":"publisher","first-page":"382","DOI":"10.3109\/10715762.2011.653969","volume":"46","author":"M Dizdaroglu","year":"2012","unstructured":"Dizdaroglu, M. & Jaruga, P. Mechanisms of free radical-induced damage to DNA. Free Radic. Res. 46, 382\u2013419. https:\/\/doi.org\/10.3109\/10715762.2011.653969 (2012).","journal-title":"Free Radic. Res."},{"key":"61766_CR10","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1152\/physrev.00018.2001","volume":"82","author":"W Dr\u00f6ge","year":"2002","unstructured":"Dr\u00f6ge, W. Free radicals in the physiological control of cell function. Physiol. Rev. 82, 47\u201395. https:\/\/doi.org\/10.1152\/physrev.00018.2001 (2002).","journal-title":"Physiol. Rev."},{"key":"61766_CR11","doi-asserted-by":"publisher","first-page":"13411","DOI":"10.1021\/la302705f","volume":"28","author":"N Shamitko-Klingensmith","year":"2012","unstructured":"Shamitko-Klingensmith, N., Molchanoff, K. M., Burke, K. A., Magnone, G. J. & Legleiter, J. Mapping the mechanical properties of cholesterol-containing supported lipid bilayers with nanoscale spatial resolution. Langmuir 28, 13411\u201313422 (2012).","journal-title":"Langmuir"},{"key":"61766_CR12","first-page":"700","volume":"335","author":"I Swapna","year":"2005","unstructured":"Swapna, I., Sathya, K. V., Murthy, C. R. & Senthilkumaran, B. Membrane alterations and fluidity changes in cerebral cortex during ammonia intoxication. Neuro Toxicol. 335, 700\u2013704 (2005).","journal-title":"Neuro Toxicol."},{"key":"61766_CR13","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.ijdevneu.2005.06.003","volume":"23","author":"FM Stefanello","year":"2005","unstructured":"Stefanello, F. M., Chiarani, F. & Kurek, A. G. Methionine alters Na+, K+ ATPase activity, lipid peroxidation and nonenzymatic antioxidant defenses in rat hippocampus. Int. J. Dev. Neurosc. 23, 651\u2013656 (2005).","journal-title":"Int. J. Dev. Neurosc."},{"key":"61766_CR14","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.neuroscience.2020.07.009","volume":"442","author":"CA Lowry","year":"2020","unstructured":"Lowry, C. A., Golod, M. E., Andrew, R. D. & Bennett, B. M. Expression of neuronal Na(+)\/K(+)-ATPase \u03b1 subunit isoforms in the mouse brain following genetically programmed or behaviourally-induced oxidative stress. Neuroscience 442, 202\u2013215. https:\/\/doi.org\/10.1016\/j.neuroscience.2020.07.009 (2020).","journal-title":"Neuroscience"},{"key":"61766_CR15","doi-asserted-by":"publisher","first-page":"359","DOI":"10.2174\/1381612824666180110101052","volume":"24","author":"J Liu","year":"2018","unstructured":"Liu, J., Lilly, M. N. & Shapiro, J. I. Targeting Na\/K-ATPase signaling: A new approach to control oxidative stress. Curr. Pharm. Des. 24, 359\u2013364. https:\/\/doi.org\/10.2174\/1381612824666180110101052 (2018).","journal-title":"Curr. Pharm. Des."},{"key":"61766_CR16","doi-asserted-by":"publisher","first-page":"19585","DOI":"10.1038\/s41598-020-76342-5","volume":"10","author":"Y Alharbi","year":"2020","unstructured":"Alharbi, Y. et al. Oxidative stress induced by the anti-cancer agents, plumbagin, and atovaquone, inhibits ion transport through Na+\/K+-ATPase. Sci. Rep. 10, 19585. https:\/\/doi.org\/10.1038\/s41598-020-76342-5 (2020).","journal-title":"Sci. Rep."},{"key":"61766_CR17","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1007\/BF00963999","volume":"8","author":"T Matsutani","year":"1983","unstructured":"Matsutani, T. et al. A neurochemical study of developmental impairment of the brain caused by the administration of cytosine arabinoside during the fetal or neonatal period of rats. Neurochem. Res. 8, 1295\u20131306. https:\/\/doi.org\/10.1007\/BF00963999 (1983).","journal-title":"Neurochem. Res."},{"key":"61766_CR18","doi-asserted-by":"publisher","first-page":"149","DOI":"10.2174\/1871527318666181128144343","volume":"18","author":"DC Guzm\u00e1n","year":"2019","unstructured":"Guzm\u00e1n, D. C. et al. Cytarabine and ferric carboxymaltose (Fe+3) increase oxidative damage and alter serotonergic metabolism in brain. CNS Neurol. Disord. Drug Target 18, 149\u2013155. https:\/\/doi.org\/10.2174\/1871527318666181128144343 (2019).","journal-title":"CNS Neurol. Disord. Drug Target"},{"key":"61766_CR19","doi-asserted-by":"publisher","first-page":"483","DOI":"10.5604\/17322693.1229074","volume":"70","author":"M Wo\u0142onciej","year":"2016","unstructured":"Wo\u0142onciej, M., Milewska, E. & Roszkowska-Jakimiec, W. Trace elements as an activator of antioxidant enzymes. Postepy. Hig. Med. Dosw 70, 483\u20131498. https:\/\/doi.org\/10.5604\/17322693.1229074 (2016).","journal-title":"Postepy. Hig. Med. Dosw"},{"key":"61766_CR20","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1080\/01635581.2018.1557214","volume":"71","author":"D Calder\u00f3n Guzm\u00e1n","year":"2019","unstructured":"Calder\u00f3n Guzm\u00e1n, D., Ju\u00e1rez Olgu\u00edn, H., Osnaya Brizuela, N., Hern\u00e1ndez Garcia, E. & Lindoro Silva, M. The use of trace and essential elements in common clinical disorders: roles in assessment of health and oxidative stress status. Nutr. Cancer 71, 13\u201320. https:\/\/doi.org\/10.1080\/01635581.2018.1557214 (2019).","journal-title":"Nutr. Cancer"},{"key":"61766_CR21","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1177\/0884533616653832","volume":"31","author":"WA Koekkoek","year":"2016","unstructured":"Koekkoek, W. A. & van Zanten, A. R. Antioxidant vitamins and oligoelements in critical illness. Nutr. Clin. Pract. 31, 457\u2013474. https:\/\/doi.org\/10.1177\/0884533616653832 (2016).","journal-title":"Nutr. Clin. Pract."},{"key":"61766_CR22","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1007\/s10238-024-01349-5","volume":"24","author":"AK Nilgun","year":"2024","unstructured":"Nilgun, A. K. & Ozturk, B. K. Comparison of trace elements in peripheral blood and bone marrow of newly diagnosed multiple myeloma patients. Clin. Exp. Med. 24, 78. https:\/\/doi.org\/10.1007\/s10238-024-01349-5 (2024).","journal-title":"Clin. Exp. Med."},{"key":"61766_CR23","doi-asserted-by":"publisher","first-page":"472","DOI":"10.3390\/nu16040472","volume":"16","author":"T Himoto","year":"2024","unstructured":"Himoto, T. & Masaki, T. Current trends on the involvement of zinc, copper, and selenium in the process of hepatocarcinogenesis. Nutrients 16, 472. https:\/\/doi.org\/10.3390\/nu16040472 (2024).","journal-title":"Nutrients"},{"key":"61766_CR24","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.breast.2018.09.005","volume":"42","author":"N Cabr\u00e9","year":"2018","unstructured":"Cabr\u00e9, N. et al. Trace element concentrations in breast cancer patients. Breast 42, 142\u2013149. https:\/\/doi.org\/10.1016\/j.breast.2018.09.005 (2018).","journal-title":"Breast"},{"key":"61766_CR25","doi-asserted-by":"publisher","first-page":"2625","DOI":"10.7314\/apjcp.2014.15.6.2625","volume":"15","author":"M Kaba","year":"2014","unstructured":"Kaba, M. et al. Serum levels of trace elements in patients with prostate cancer. Asian Pac. J. Cancer Prev. 15, 2625\u20132629. https:\/\/doi.org\/10.7314\/apjcp.2014.15.6.2625 (2014).","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"61766_CR26","doi-asserted-by":"publisher","first-page":"126451","DOI":"10.1016\/j.jtemb.2020.126451","volume":"59","author":"JT Juloski","year":"2020","unstructured":"Juloski, J. T. et al. Colorectal cancer and oligoelements alteration. J. Trace Elem. Med. Biol. 59, 126451. https:\/\/doi.org\/10.1016\/j.jtemb.2020.126451 (2020).","journal-title":"J. Trace Elem. Med. Biol."},{"key":"61766_CR27","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s12011-016-0667-6","volume":"173","author":"Z Liu","year":"2016","unstructured":"Liu, Z., Yang, W., Long, G. & Wei, C. Oligoelements and chemotherapy sensitivity. Biol. Trace Elem. Res. 173, 283\u2013290. https:\/\/doi.org\/10.1007\/s12011-016-0667-6 (2016).","journal-title":"Biol. Trace Elem. Res."},{"key":"61766_CR28","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/978-1-4419-5819-8_6","volume":"671","author":"L Baird","year":"2010","unstructured":"Baird, L. & Terskikh, A. The tumor microenvironment. Adv. Exp. Med. Biol. 671, 67\u201373. https:\/\/doi.org\/10.1007\/978-1-4419-5819-8_6 (2010).","journal-title":"Adv. Exp. Med. Biol."},{"key":"61766_CR29","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.2298\/ABS1304371G","volume":"65","author":"GD Calderon","year":"2013","unstructured":"Calderon, G. D., Juarez, O. H. & Hernandez, G. E. Effect of an antiviral and vitamins A, C, D on dopamine and some oxidative stress markers in rat brain exposed to ozone. Arch. Biol. Sci. 65, 1371\u20131379. https:\/\/doi.org\/10.2298\/ABS1304371G (2013).","journal-title":"Arch. Biol. Sci."},{"key":"61766_CR30","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1126\/science.7022654","volume":"213","author":"W Mertz","year":"1981","unstructured":"Mertz, W. The essential trace elements. Science 213, 1332\u20131338. https:\/\/doi.org\/10.1126\/science.7022654 (1981).","journal-title":"Science"},{"key":"61766_CR31","doi-asserted-by":"publisher","first-page":"126858","DOI":"10.1016\/j.jtemb.2021.126858","volume":"68","author":"E Rodr\u00edguez-Tom\u00e0s","year":"2021","unstructured":"Rodr\u00edguez-Tom\u00e0s, E. et al. Trace elements under the spotlight: A powerful nutritional tool in c\u00e1ncer. J. Trace Elem. Med. Biol. 68, 126858. https:\/\/doi.org\/10.1016\/j.jtemb.2021.126858 (2021).","journal-title":"J. Trace Elem. Med. Biol."},{"key":"61766_CR32","doi-asserted-by":"publisher","first-page":"4770","DOI":"10.3390\/ijms22094770","volume":"22","author":"I Genovese","year":"2021","unstructured":"Genovese, I. et al. Mitochondria: Insights into crucial features to overcome cancer chemoresistance. Int. J. Mol. Sci. 22, 4770. https:\/\/doi.org\/10.3390\/ijms22094770 (2021).","journal-title":"Int. J. Mol. Sci."},{"issue":"23","key":"61766_CR33","doi-asserted-by":"publisher","first-page":"00062","DOI":"10.1016\/j.jare.2023.02.011","volume":"S2090\u20131232","author":"S Wang","year":"2013","unstructured":"Wang, S., Chan, S. Y., Deng, Y., Khoo, B. L. & Chua, S. L. Oxidative stress induced by etoposide anti-cancer chemotherapy drives the emergence of tumor-associated bacteria resistance to fluoroquinolones. J. Adv. Res. S2090\u20131232(23), 00062. https:\/\/doi.org\/10.1016\/j.jare.2023.02.011 (2013).","journal-title":"J. Adv. Res."},{"key":"61766_CR34","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/j.bbabio.2017.01.012","volume":"1858","author":"F Guerra","year":"2017","unstructured":"Guerra, F., Arbini, A. A. & Moro, L. Mitochondria and cancer chemoresistance. Biochim. Biophys. Acta Bioenerg. 1858, 686\u2013699. https:\/\/doi.org\/10.1016\/j.bbabio.2017.01.012 (2017).","journal-title":"Biochim. Biophys. Acta Bioenerg."},{"key":"61766_CR35","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/963520","author":"A Popa-Wagner","year":"2013","unstructured":"Popa-Wagner, A., Mitran, S., Sivanesan, S., Chang, E. & Buga, A. M. ROS and brain diseases: the good, the bad, and the ugly. Oxid. Med. Cell Longev. https:\/\/doi.org\/10.1155\/2013\/963520 (2013).","journal-title":"Oxid. Med. Cell Longev."},{"key":"61766_CR36","doi-asserted-by":"publisher","first-page":"113983","DOI":"10.1016\/j.fct.2023.113983","volume":"179","author":"K Jahankhani","year":"2013","unstructured":"Jahankhani, K. et al. Therapeutic effect of trace elements on multiple myeloma and mechanisms of cancer process. Food Chem. Toxicol. 179, 113983. https:\/\/doi.org\/10.1016\/j.fct.2023.113983 (2013).","journal-title":"Food Chem. Toxicol."},{"key":"61766_CR37","doi-asserted-by":"publisher","first-page":"101900","DOI":"10.1016\/j.redox.2021.101900","volume":"42","author":"K Lossow","year":"2021","unstructured":"Lossow, K., Schwarz, M. & Kipp, A. P. Are trace element concentrations suitable biomarkers for the diagnosis of cancer?. Redox Biol. 42, 101900. https:\/\/doi.org\/10.1016\/j.redox.2021.101900 (2021).","journal-title":"Redox Biol."},{"key":"61766_CR38","doi-asserted-by":"publisher","first-page":"7772","DOI":"10.1007\/s11356-018-4019-2","volume":"26","author":"A Koltsakidou","year":"2019","unstructured":"Koltsakidou, A., Antonopoulou, M., \u0395vgenidou, E., Konstantinoum, I. & Lambropoulou, D. A comparative study on the photo-catalytic degradation of cytarabine anticancer drug under Fe3+\/H2O2, Fe3+\/S2O82-, and [Fe(C2O4)3]3-\/H2O2 processes. Kinetics, identification, and in silico toxicity assessment of generated transformation products. Environ. Sci. Pollut. Res. Int. 26, 7772\u20137784 (2019).","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"61766_CR39","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/2035682","author":"S Tan","year":"2019","unstructured":"Tan, S. et al. Sodium selenite accentuates the therapeutic effect of adriamycin prodrug (PADM) against gastric cancer. Biomed. Res. Int. https:\/\/doi.org\/10.1155\/2019\/2035682 (2019).","journal-title":"Biomed. Res. Int."},{"key":"61766_CR40","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1002\/pros.23772","volume":"79","author":"YN Xue","year":"2019","unstructured":"Xue, Y. N. et al. Zinc promotes prostate cancer cell chemosensitivity to paclitaxel by inhibiting epithelial-mesenchymal transition and inducing apoptosis. Prostate 79, 647\u2013656. https:\/\/doi.org\/10.1002\/pros.23772 (2019).","journal-title":"Prostate"},{"key":"61766_CR41","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1016\/j.phymed.2016.09.005","volume":"23","author":"HM Lee","year":"2016","unstructured":"Lee, H. M., Patel, V., Shyur, L. F. & Lee, W. L. Copper supplementation amplifies the anti-tumor effect of curcumin in oral cancer cells. Phytomedicine 23, 1535\u20131544. https:\/\/doi.org\/10.1016\/j.phymed.2016.09.005 (2016).","journal-title":"Phytomedicine"},{"key":"61766_CR42","doi-asserted-by":"publisher","first-page":"897","DOI":"10.2174\/138920006779010638","volume":"7","author":"N Zheng","year":"2006","unstructured":"Zheng, N. et al. Characterization of an etoposide-glutathione conjugate derived from metabolic activation by human cytochrome p450. Curr. Drug Metab. 7, 897\u2013911. https:\/\/doi.org\/10.2174\/138920006779010638 (2006).","journal-title":"Curr. Drug Metab."},{"key":"61766_CR43","first-page":"7777","volume":"61","author":"VE Kagan","year":"2001","unstructured":"Kagan, V. E. et al. Pro-oxidant and antioxidant mechanisms of etoposide in HL-60 cells: Role of myeloperoxidase. Cancer Res. 61, 7777\u20137784 (2001).","journal-title":"Cancer Res."},{"key":"61766_CR44","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1046\/j.1471-4159.1997.69041499.x","volume":"69","author":"PP Michel","year":"1997","unstructured":"Michel, P. P., Ruberg, M. & Agid, Y. Rescue of mesencephalic dopamine neurons by anticancer drug cytosine arabinoside. J. Neurochem. 69, 1499\u20131507. https:\/\/doi.org\/10.1046\/j.1471-4159.1997.69041499.x (1997).","journal-title":"J. Neurochem."},{"key":"61766_CR45","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9730467","author":"H Ju\u00e1rez Olgu\u00edn","year":"2016","unstructured":"Ju\u00e1rez Olgu\u00edn, H., Calder\u00f3n Guzm\u00e1n, D., Hern\u00e1ndez Garc\u00eda, E. & Barrag\u00e1n Mej\u00eda, G. The role of dopamine and its dysfunction as a consequence of oxidative stress. Oxid. Med. Cell Longev. https:\/\/doi.org\/10.1155\/2016\/9730467 (2016).","journal-title":"Oxid. Med. Cell Longev."},{"key":"61766_CR46","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1016\/j.cell.2012.03.049","volume":"149","author":"E Sachlos","year":"2012","unstructured":"Sachlos, E. et al. Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells. Cell 149, 1284\u20131297. https:\/\/doi.org\/10.1016\/j.cell.2012.03.049 (2012).","journal-title":"Cell"},{"key":"61766_CR47","doi-asserted-by":"publisher","first-page":"1295185","DOI":"10.3389\/fonc.2023.1295185","volume":"13","author":"M Vanneste","year":"2013","unstructured":"Vanneste, M. et al. The anti-cancer efficacy of a novel phenothiazine derivative is independent of dopamine and serotonin receptor inhibition. Front. Oncol. 13, 1295185. https:\/\/doi.org\/10.3389\/fonc.2023.1295185 (2013).","journal-title":"Front. Oncol."},{"key":"61766_CR48","doi-asserted-by":"publisher","first-page":"735","DOI":"10.3390\/cells10040735","volume":"10","author":"L Speranza","year":"2021","unstructured":"Speranza, L., di Porzio, U., Viggiano, D., de Donato, A. & Volpicelli, F. Dopamine: The neuromodulator of long-term synaptic plasticity, reward and movement control. Cells 10, 735. https:\/\/doi.org\/10.3390\/cells10040735 (2021).","journal-title":"Cells"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-61766-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-61766-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-61766-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T05:01:49Z","timestamp":1715490109000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-61766-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,12]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["61766"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-61766-0","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,12]]},"assertion":[{"value":"26 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"10835"}}