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Another concern facing physicians is rising global incidence of drug-resistant <jats:italic>Candida.<\/jats:italic> This study aimed to characterize the prevalence, antifungal susceptibility, biofilm formation, and virulence genes (HWP1, ALS1, SAP2) of different <jats:italic>Candida<\/jats:italic>\u00a0spp. isolated from patients with candidemia. 52 isolates of <jats:italic>Candida<\/jats:italic>\u00a0spp. were identified from blood cultures by chromogenic <jats:italic>Candida<\/jats:italic> agar and confirmed by the VITEK 2 system. Isolates were tested for antifungal susceptibility by disk diffusion and VITEK 2 system. Biofilm formation and investigated genes were detected by the Congo red method and conventional PCR, respectively. <jats:italic>Candida<\/jats:italic> spp. caused 2.3% of detected BSIs, of which 32.7% were caused by <jats:italic>Candida albicans<\/jats:italic> (<jats:italic>C. albicans<\/jats:italic>) and 67.3% by non-<jats:italic>albicans Candida<\/jats:italic> (NAC), with the predominance of <jats:italic>C. tropicalis<\/jats:italic> (25%), followed by <jats:italic>C. parapsilosis<\/jats:italic> (17.3%), and <jats:italic>C. krusei<\/jats:italic> (13.5%). The susceptibility rates to fluconazole, voriconazole, caspofungin, micafungin, amphotericin B, and flucytosine were 64.7%, 76.5%, 100.0%, 100%, 100.0%, and 100.0% in <jats:italic>C. albicans,<\/jats:italic> while 53.6%, 71.4%, 91.4%, 91.4%, 94.3%, and 94.3% in NAC, respectively. Biofilm production, HWP1, ALS1, and SAP2 were detected in 70.6%, 82.4%, 76.5%, and 52.9% of <jats:italic>C. albicans<\/jats:italic> and 74.3%, 85.7%, 80.0%, and 48.6% of NAC, respectively. There is remarkable shift to NAC BSIs and high azole resistance. Antifungal stewardship and analysis of risk factors associated with this shift are needed.<\/jats:p>","DOI":"10.1038\/s41598-024-61813-w","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T12:02:18Z","timestamp":1716292938000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Antifungal susceptibility and virulence determinants profile of candida species isolated from patients with candidemia"],"prefix":"10.1038","volume":"14","author":[{"given":"Amal M.","family":"Dawoud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8183-7868","authenticated-orcid":false,"given":"Sara A.","family":"Saied","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad M.","family":"Torayah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira E.","family":"Ramadan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shymaa A.","family":"Elaskary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,21]]},"reference":[{"issue":"14","key":"61813_CR1","doi-asserted-by":"publisher","first-page":"1092175","DOI":"10.3389\/fmicb.2023.1092175","volume":"14","author":"B Yang","year":"2023","unstructured":"Yang, B., Wei, Z., Wu, M., Lai, Y. & Zhao, W. 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