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A retrospective, multireader, randomized study was conducted to validate the performance of an AI algorithm in differentiating AIH from CCM on brain CT. CT images of CM and AIH (&lt;\u20093\u00a0cm) were identified from the database. Six blinded reviewers, including two neuroradiologists, two radiology residents, and two emergency department physicians, evaluated CT images from 288 patients (CCM, n\u2009=\u2009173; AIH, n\u2009=\u2009115) with and without AI assistance, comparing diagnostic performance. Brain CT interpretation with AI assistance resulted in significantly higher diagnostic accuracy than without (86.92% vs. 79.86%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Radiology residents and emergency department physicians showed significantly improved accuracy of CT interpretation with AI assistance than without (84.21% vs. 75.35%, 80.73% vs. 72.57%; respectively, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Neuroradiologists showed a trend of higher accuracy with AI assistance in the interpretation but lacked statistical significance (95.83% vs. 91.67%, <jats:italic>p<\/jats:italic>\u2009=\u20090.56). The use of an AI algorithm can enhance the differentiation of AIH from CCM in brain CT interpretation, particularly for nonexperts in neuroradiology.<\/jats:p>","DOI":"10.1038\/s41598-024-61960-0","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T15:02:53Z","timestamp":1716476573000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Improved differentiation of cavernous malformation and acute intraparenchymal hemorrhage on CT using an AI algorithm"],"prefix":"10.1038","volume":"14","author":[{"given":"Jung Youn","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye Jeong","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Heum","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hwangseon","family":"Ju","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,5,23]]},"reference":[{"key":"61960_CR1","first-page":"389","volume":"6","author":"J Ahmadi","year":"1985","unstructured":"Ahmadi, J. et al. 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