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Totally, 78 patients who underwent both <jats:sup>18<\/jats:sup>F-fluorodeoxyglucose (FDG) and <jats:sup>18<\/jats:sup>F-FAPI PET\/CT examinations were divided into normal (n\u2009=\u200953) and NSU (n\u2009=\u200925) groups. The differences in general information, medical history, laboratory indexes and uptake were compared. Receiver operating characteristic (ROC) curves were used to analyze the optimal cut-off values. The correlations between <jats:sup>18<\/jats:sup>F-FAPI-SUVmax and blood cell analysis, liver function\u00a0indexes, tumor markers, and inflammatory indices were analyzed. The logistic regression model was used to estimate the independent factors. Both <jats:sup>18<\/jats:sup>F-FAPI (4.48\u2009\u00b1\u20090.98 vs. 2.01\u2009\u00b1\u20090.53, <jats:italic>t<\/jats:italic>\u2009=\u200911.718, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and <jats:sup>18<\/jats:sup>F-FDG (2.23\u2009\u00b1\u20090.42 vs. 2.02\u2009\u00b1\u20090.44, <jats:italic>t<\/jats:italic>\u2009=\u20092.036, <jats:italic>P<\/jats:italic>\u2009=\u20090.045) showed significantly higher in NSU group. Patients in the NSU group tended to be complicated with a history of drinking (<jats:italic>P<\/jats:italic>\u2009=\u20090.034), chronic liver diseases (<jats:italic>P<\/jats:italic>\u2009=\u20090.006), and surgery of gastrectomy (<jats:italic>P<\/jats:italic>\u2009=\u20090.004). ROC analysis showed cutoff values of 3.25 and 2.05 for <jats:sup>18<\/jats:sup>F-FAPI and <jats:sup>18<\/jats:sup>F-FDG in identifying the NSU. Patients in the NSU group showed less platelet count, higher platelet volume, higher total bilirubin, direct or indirect bilirubin (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Platelet count, platelet crit, large platelet ratio, aspartate aminotransferase (AST), \u03b1-<jats:sc>l<\/jats:sc>-fucosidase, and total, direct or indirect bilirubin were correlated with <jats:sup>18<\/jats:sup>F-FAPI-SUVmax (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). AST [1.099 (1.014, 1.192), <jats:italic>P<\/jats:italic>\u2009=\u20090.021] and total bilirubin [1.137 (1.035, 1.249), <jats:italic>P<\/jats:italic>\u2009=\u20090.007] were two independent factors in the step forward logistic regression, and platelet\/% [1.079 (1.004, 1.160), <jats:italic>P<\/jats:italic>\u2009=\u20090.039] and total bilirubin [1.459 (1.016, 2.095), <jats:italic>P<\/jats:italic>\u2009=\u20090.041] were two independent factors in the step backward logistic regression for the prediction of pancreatic uptake of <jats:sup>18<\/jats:sup>F-FAPI. <jats:sup>18<\/jats:sup>F-FAPI-PET\/CT was better than <jats:sup>18<\/jats:sup>F-FDG in predicting the pancreatic NSU, and NSU is related to a history of drinking, chronic liver diseases, gastrectomy, heteromorphic platelet, and impaired liver function.<\/jats:p>","DOI":"10.1038\/s41598-024-62005-2","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T13:02:45Z","timestamp":1715778165000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Non-specific uptake of 18F-FAPI-04 in the pancreas and its related factors: a post-hoc analysis of an ongoing prospective clinical trial"],"prefix":"10.1038","volume":"14","author":[{"given":"Yan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jungang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5521-1612","authenticated-orcid":false,"given":"Cong","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,15]]},"reference":[{"key":"62005_CR1","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.2967\/jnumed.119.236786","volume":"61","author":"C Meyer","year":"2020","unstructured":"Meyer, C. et al. 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